link
Bookmarks
Primary CNS Lymphoma
Karen L. Salzman, MD
To access 4,300 diagnoses written by the world's leading experts in radiology, please log in or subscribe.Log inSubscribe
0
19
18
3

KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Abbreviations

              • Primary central nervous system lymphoma (PCNSL)
            • Definitions

              • Extranodal malignant lymphoma arising in CNS in absence of systemic lymphoma
              • Malignant primary CNS neoplasm primarily composed of B lymphocytes

            IMAGING

            • General Features

              • CT Findings

                • MR Findings

                  • Nuclear Medicine Findings

                    • Imaging Recommendations

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Staging, Grading, & Classification

                            • Gross Pathologic & Surgical Features

                              • Microscopic Features

                                CLINICAL ISSUES

                                • Presentation

                                  • Demographics

                                    • Natural History & Prognosis

                                      • Treatment

                                        DIAGNOSTIC CHECKLIST

                                        • Consider

                                          • Image Interpretation Pearls

                                            Selected References

                                            1. Lu SS et al: Histogram analysis of apparent diffusion coefficient maps for differentiating primary CNS lymphomas from tumefactive demyelinating lesions. AJR Am J Roentgenol. 204(4):827-34, 2015
                                            2. Matinella A et al: Neurological complications of HIV infection in pre-HAART and HAART era: a retrospective study. J Neurol. 262(5):1317-27, 2015
                                            3. Yamasaki F et al: Magnetic resonance spectroscopy detection of high lipid levels in intraaxial tumors without central necrosis: a characteristic of malignant lymphoma. J Neurosurg. 122(6):1370-9, 2015
                                            4. Kickingereder P et al: Evaluation of microvascular permeability with dynamic contrast-enhanced MRI for the differentiation of primary CNS lymphoma and glioblastoma: radiologic-pathologic correlation. AJNR Am J Neuroradiol. 35(8):1503-8, 2014
                                            5. Mansour A et al: MR imaging features of intracranial primary CNS lymphoma in immune competent patients. Cancer Imaging. 14:22, 2014
                                            6. Angelov L et al: Blood-Brain Barrier Disruption and Intra-Arterial Methotrexate-Based Therapy for Newly Diagnosed Primary CNS Lymphoma: A Multi-Institutional Experience. J Clin Oncol. Epub ahead of print, 2009
                                            7. Correa DD et al: Prospective cognitive follow-up in primary CNS lymphoma patients treated with chemotherapy and reduced-dose radiotherapy. J Neurooncol. 91(3):315-21, 2009
                                            8. Imai H et al: Comparative clinicopathological study of primary CNS diffuse large B-cell lymphoma and intravascular large B-cell lymphoma. Pathol Int. 59(7):431-7, 2009
                                            9. Kim DS et al: Distinguishing tumefactive demyelinating lesions from glioma or central nervous system lymphoma: added value of unenhanced CT compared with conventional contrast-enhanced MR imaging. Radiology. 251(2):467-75, 2009
                                            10. Lee IH et al: Analysis of perfusion weighted image of CNS lymphoma. Eur J Radiol. Epub ahead of print, 2009
                                            11. Liao W et al: Differentiation of primary central nervous system lymphoma and high-grade glioma with dynamic susceptibility contrast-enhanced perfusion magnetic resonance imaging. Acta Radiol. 50(2):217-25, 2009
                                            12. Sierra del Rio M et al: Primary CNS lymphoma in immunocompetent patients. Oncologist. 14(5):526-39, 2009
                                            13. Fischer L et al: Meningeal dissemination in primary CNS lymphoma: prospective evaluation of 282 patients. Neurology. 71(14):1102-8, 2008
                                            14. Kleinschmidt-DeMasters BK et al: Epstein Barr virus-associated primary CNS lymphomas in elderly patients on immunosuppressive medications. J Neuropathol Exp Neurol. 67(11):1103-11, 2008
                                            15. Mohile NA et al: The utility of body FDG PET in staging primary central nervous system lymphoma. Neuro Oncol. 10(2):223-8, 2008
                                            16. Toh CH et al: Primary cerebral lymphoma and glioblastoma multiforme: differences in diffusion characteristics evaluated with diffusion tensor imaging. AJNR Am J Neuroradiol. 29(3):471-5, 2008
                                            17. Louis DN et al: WHO Classification of Tumours of the Central Nervous System: Malignant lymphomas. Lyon: IARC Press. 188-92, 2007
                                            18. Abrey LE et al: Primary central nervous system lymphoma: the Memorial Sloan-Kettering Cancer Center prognostic model. J Clin Oncol. 24(36):5711-5, 2006
                                            19. Hunt MA et al: Distinguishing primary central nervous system lymphoma from other central nervous system diseases: a neurosurgical perspective on diagnostic dilemmas and approaches. Neurosurg Focus. 21(5):E3, 2006
                                            20. Iwamoto FM et al: Primary dural lymphomas: a review. Neurosurg Focus. 21(5):E5, 2006
                                            21. Stadnik TW et al: Diffusion-weighted MR imaging of intracerebral masses: comparison with conventional MR imaging and histologic findings. AJNR Am J Neuroradiol. 22(5):969-76, 2001
                                            22. Bataille B et al: Primary intracerebral malignant lymphoma: report of 248 cases. J Neurosurg. 92(2):261-6, 2000
                                            23. Schlegel U et al: Primary CNS lymphoma: clinical presentation, pathological classification, molecular pathogenesis and treatment. J Neurol Sci. 181(1-2): 1-12, 2000
                                            24. Koeller KK et al: Primary central nervous system lymphoma: radiologic-pathologic correlation. Radiographics. 17(6): 1497-526, 1997
                                            Related Anatomy
                                            Loading...
                                            Related Differential Diagnoses
                                            Loading...
                                            References
                                            Tables

                                            Tables

                                            KEY FACTS

                                            • Terminology

                                              • Imaging

                                                • Top Differential Diagnoses

                                                  • Pathology

                                                    • Clinical Issues

                                                      TERMINOLOGY

                                                      • Abbreviations

                                                        • Primary central nervous system lymphoma (PCNSL)
                                                      • Definitions

                                                        • Extranodal malignant lymphoma arising in CNS in absence of systemic lymphoma
                                                        • Malignant primary CNS neoplasm primarily composed of B lymphocytes

                                                      IMAGING

                                                      • General Features

                                                        • CT Findings

                                                          • MR Findings

                                                            • Nuclear Medicine Findings

                                                              • Imaging Recommendations

                                                                DIFFERENTIAL DIAGNOSIS

                                                                  PATHOLOGY

                                                                  • General Features

                                                                    • Staging, Grading, & Classification

                                                                      • Gross Pathologic & Surgical Features

                                                                        • Microscopic Features

                                                                          CLINICAL ISSUES

                                                                          • Presentation

                                                                            • Demographics

                                                                              • Natural History & Prognosis

                                                                                • Treatment

                                                                                  DIAGNOSTIC CHECKLIST

                                                                                  • Consider

                                                                                    • Image Interpretation Pearls

                                                                                      Selected References

                                                                                      1. Lu SS et al: Histogram analysis of apparent diffusion coefficient maps for differentiating primary CNS lymphomas from tumefactive demyelinating lesions. AJR Am J Roentgenol. 204(4):827-34, 2015
                                                                                      2. Matinella A et al: Neurological complications of HIV infection in pre-HAART and HAART era: a retrospective study. J Neurol. 262(5):1317-27, 2015
                                                                                      3. Yamasaki F et al: Magnetic resonance spectroscopy detection of high lipid levels in intraaxial tumors without central necrosis: a characteristic of malignant lymphoma. J Neurosurg. 122(6):1370-9, 2015
                                                                                      4. Kickingereder P et al: Evaluation of microvascular permeability with dynamic contrast-enhanced MRI for the differentiation of primary CNS lymphoma and glioblastoma: radiologic-pathologic correlation. AJNR Am J Neuroradiol. 35(8):1503-8, 2014
                                                                                      5. Mansour A et al: MR imaging features of intracranial primary CNS lymphoma in immune competent patients. Cancer Imaging. 14:22, 2014
                                                                                      6. Angelov L et al: Blood-Brain Barrier Disruption and Intra-Arterial Methotrexate-Based Therapy for Newly Diagnosed Primary CNS Lymphoma: A Multi-Institutional Experience. J Clin Oncol. Epub ahead of print, 2009
                                                                                      7. Correa DD et al: Prospective cognitive follow-up in primary CNS lymphoma patients treated with chemotherapy and reduced-dose radiotherapy. J Neurooncol. 91(3):315-21, 2009
                                                                                      8. Imai H et al: Comparative clinicopathological study of primary CNS diffuse large B-cell lymphoma and intravascular large B-cell lymphoma. Pathol Int. 59(7):431-7, 2009
                                                                                      9. Kim DS et al: Distinguishing tumefactive demyelinating lesions from glioma or central nervous system lymphoma: added value of unenhanced CT compared with conventional contrast-enhanced MR imaging. Radiology. 251(2):467-75, 2009
                                                                                      10. Lee IH et al: Analysis of perfusion weighted image of CNS lymphoma. Eur J Radiol. Epub ahead of print, 2009
                                                                                      11. Liao W et al: Differentiation of primary central nervous system lymphoma and high-grade glioma with dynamic susceptibility contrast-enhanced perfusion magnetic resonance imaging. Acta Radiol. 50(2):217-25, 2009
                                                                                      12. Sierra del Rio M et al: Primary CNS lymphoma in immunocompetent patients. Oncologist. 14(5):526-39, 2009
                                                                                      13. Fischer L et al: Meningeal dissemination in primary CNS lymphoma: prospective evaluation of 282 patients. Neurology. 71(14):1102-8, 2008
                                                                                      14. Kleinschmidt-DeMasters BK et al: Epstein Barr virus-associated primary CNS lymphomas in elderly patients on immunosuppressive medications. J Neuropathol Exp Neurol. 67(11):1103-11, 2008
                                                                                      15. Mohile NA et al: The utility of body FDG PET in staging primary central nervous system lymphoma. Neuro Oncol. 10(2):223-8, 2008
                                                                                      16. Toh CH et al: Primary cerebral lymphoma and glioblastoma multiforme: differences in diffusion characteristics evaluated with diffusion tensor imaging. AJNR Am J Neuroradiol. 29(3):471-5, 2008
                                                                                      17. Louis DN et al: WHO Classification of Tumours of the Central Nervous System: Malignant lymphomas. Lyon: IARC Press. 188-92, 2007
                                                                                      18. Abrey LE et al: Primary central nervous system lymphoma: the Memorial Sloan-Kettering Cancer Center prognostic model. J Clin Oncol. 24(36):5711-5, 2006
                                                                                      19. Hunt MA et al: Distinguishing primary central nervous system lymphoma from other central nervous system diseases: a neurosurgical perspective on diagnostic dilemmas and approaches. Neurosurg Focus. 21(5):E3, 2006
                                                                                      20. Iwamoto FM et al: Primary dural lymphomas: a review. Neurosurg Focus. 21(5):E5, 2006
                                                                                      21. Stadnik TW et al: Diffusion-weighted MR imaging of intracerebral masses: comparison with conventional MR imaging and histologic findings. AJNR Am J Neuroradiol. 22(5):969-76, 2001
                                                                                      22. Bataille B et al: Primary intracerebral malignant lymphoma: report of 248 cases. J Neurosurg. 92(2):261-6, 2000
                                                                                      23. Schlegel U et al: Primary CNS lymphoma: clinical presentation, pathological classification, molecular pathogenesis and treatment. J Neurol Sci. 181(1-2): 1-12, 2000
                                                                                      24. Koeller KK et al: Primary central nervous system lymphoma: radiologic-pathologic correlation. Radiographics. 17(6): 1497-526, 1997