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Primary Sclerosing Cholangitis
Siva P. Raman, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Pathology

        • Clinical Issues

          TERMINOLOGY

          • Abbreviations

            • Primary sclerosing cholangitis (PSC)
          • Definitions

            • Chronic, immune-mediated disease causing progressive inflammation, fibrosis, and stricturing of the intrahepatic and extrahepatic ducts

          IMAGING

          • General Features

            • MR Findings

              • CT Findings

                • Radiographic Findings

                  • Ultrasonographic Findings

                    • Imaging Recommendations

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Gross Pathologic & Surgical Features

                            • Microscopic Features

                              CLINICAL ISSUES

                              • Presentation

                                • Demographics

                                  • Natural History & Prognosis

                                    • Treatment

                                      DIAGNOSTIC CHECKLIST

                                      • Consider

                                        • Image Interpretation Pearls

                                          Selected References

                                          1. Costello JR et al: MR Imaging of Benign and Malignant Biliary Conditions. Magn Reson Imaging Clin N Am. 22(3):467-488, 2014
                                          2. Williamson KD et al: Primary sclerosing cholangitis. Dig Dis. 32(4):438-45, 2014
                                          3. Arrivé L et al: MRI of cholangitis: traps and tips. Diagn Interv Imaging. 94(7-8):757-70, 2013
                                          4. Chundru S et al: MRI of diffuse liver disease: the common and uncommon etiologies. Diagn Interv Radiol. 19(6):479-87, 2013
                                          5. Hirschfield GM et al: Primary sclerosing cholangitis. Lancet. 382(9904):1587-99, 2013
                                          6. Kovač JD et al: MR imaging of primary sclerosing cholangitis: additional value of diffusion-weighted imaging and ADC measurement. Acta Radiol. 54(3):242-8, 2013
                                          7. Zein CO: Primary sclerosing cholangitis. Clin Liver Dis. 17(2):211-27, 2013
                                          8. Azizi L et al: MR Imaging of sclerosing cholangitis. Clin Res Hepatol Gastroenterol. 36(2):130-8, 2012
                                          9. Barnabas A et al: Primary sclerosing cholangitis: is any treatment worthwhile? Curr Gastroenterol Rep. 14(1):17-24, 2012
                                          10. Krones E et al: Evolving concepts in primary sclerosing cholangitis. Liver Int. 32(3):352-69, 2012
                                          11. Karlsen TH et al: Update on primary sclerosing cholangitis. Dig Liver Dis. 42(6):390-400, 2010
                                          12. Menias CO et al: Mimics of cholangiocarcinoma: spectrum of disease. Radiographics. 28(4):1115-29, 2008
                                          13. Elsayes KM et al: MR and MRCP in the evaluation of primary sclerosing cholangitis: current applications and imaging findings. J Comput Assist Tomogr. 30(3):398-404, 2006
                                          14. Bader TR et al: MR imaging features of primary sclerosing cholangitis: patterns of cirrhosis in relationship to clinical severity of disease. Radiology. 226(3):675-85, 2003
                                          15. Campbell WL et al: Using CT and cholangiography to diagnose biliary tract carcinoma complicating primary sclerosing cholangitis. AJR Am J Roentgenol. 177(5):1095-100, 2001
                                          16. Fulcher AS et al: Primary sclerosing cholangitis: evaluation with MR cholangiography-a case-control study. Radiology. 215(1):71-80, 2000
                                          17. Vitellas KM et al: Radiologic manifestations of sclerosing cholangitis with emphasis on MR cholangiopancreatography. Radiographics. 20(4):959-75; quiz 1108-9, 1112, 2000
                                          Related Anatomy
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                                          Related Differential Diagnoses
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                                          References
                                          Tables

                                          Tables

                                          KEY FACTS

                                          • Terminology

                                            • Imaging

                                              • Pathology

                                                • Clinical Issues

                                                  TERMINOLOGY

                                                  • Abbreviations

                                                    • Primary sclerosing cholangitis (PSC)
                                                  • Definitions

                                                    • Chronic, immune-mediated disease causing progressive inflammation, fibrosis, and stricturing of the intrahepatic and extrahepatic ducts

                                                  IMAGING

                                                  • General Features

                                                    • MR Findings

                                                      • CT Findings

                                                        • Radiographic Findings

                                                          • Ultrasonographic Findings

                                                            • Imaging Recommendations

                                                              DIFFERENTIAL DIAGNOSIS

                                                                PATHOLOGY

                                                                • General Features

                                                                  • Gross Pathologic & Surgical Features

                                                                    • Microscopic Features

                                                                      CLINICAL ISSUES

                                                                      • Presentation

                                                                        • Demographics

                                                                          • Natural History & Prognosis

                                                                            • Treatment

                                                                              DIAGNOSTIC CHECKLIST

                                                                              • Consider

                                                                                • Image Interpretation Pearls

                                                                                  Selected References

                                                                                  1. Costello JR et al: MR Imaging of Benign and Malignant Biliary Conditions. Magn Reson Imaging Clin N Am. 22(3):467-488, 2014
                                                                                  2. Williamson KD et al: Primary sclerosing cholangitis. Dig Dis. 32(4):438-45, 2014
                                                                                  3. Arrivé L et al: MRI of cholangitis: traps and tips. Diagn Interv Imaging. 94(7-8):757-70, 2013
                                                                                  4. Chundru S et al: MRI of diffuse liver disease: the common and uncommon etiologies. Diagn Interv Radiol. 19(6):479-87, 2013
                                                                                  5. Hirschfield GM et al: Primary sclerosing cholangitis. Lancet. 382(9904):1587-99, 2013
                                                                                  6. Kovač JD et al: MR imaging of primary sclerosing cholangitis: additional value of diffusion-weighted imaging and ADC measurement. Acta Radiol. 54(3):242-8, 2013
                                                                                  7. Zein CO: Primary sclerosing cholangitis. Clin Liver Dis. 17(2):211-27, 2013
                                                                                  8. Azizi L et al: MR Imaging of sclerosing cholangitis. Clin Res Hepatol Gastroenterol. 36(2):130-8, 2012
                                                                                  9. Barnabas A et al: Primary sclerosing cholangitis: is any treatment worthwhile? Curr Gastroenterol Rep. 14(1):17-24, 2012
                                                                                  10. Krones E et al: Evolving concepts in primary sclerosing cholangitis. Liver Int. 32(3):352-69, 2012
                                                                                  11. Karlsen TH et al: Update on primary sclerosing cholangitis. Dig Liver Dis. 42(6):390-400, 2010
                                                                                  12. Menias CO et al: Mimics of cholangiocarcinoma: spectrum of disease. Radiographics. 28(4):1115-29, 2008
                                                                                  13. Elsayes KM et al: MR and MRCP in the evaluation of primary sclerosing cholangitis: current applications and imaging findings. J Comput Assist Tomogr. 30(3):398-404, 2006
                                                                                  14. Bader TR et al: MR imaging features of primary sclerosing cholangitis: patterns of cirrhosis in relationship to clinical severity of disease. Radiology. 226(3):675-85, 2003
                                                                                  15. Campbell WL et al: Using CT and cholangiography to diagnose biliary tract carcinoma complicating primary sclerosing cholangitis. AJR Am J Roentgenol. 177(5):1095-100, 2001
                                                                                  16. Fulcher AS et al: Primary sclerosing cholangitis: evaluation with MR cholangiography-a case-control study. Radiology. 215(1):71-80, 2000
                                                                                  17. Vitellas KM et al: Radiologic manifestations of sclerosing cholangitis with emphasis on MR cholangiopancreatography. Radiographics. 20(4):959-75; quiz 1108-9, 1112, 2000