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Prior Chest Radiation Therapy, Surveillance
Stamatia Destounis, MD; Wei Tse Yang, MBBS
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          TERMINOLOGY

          • Definitions

            • High risk of secondary breast cancer after chest XRT, usually for Hodgkin lymphoma (HL), if treated > age 10 & < age 30
              • Sequelae of mantle radiation to mediastinum and axillae (lungs shielded); practice ceased in 1990s
              • Risk of secondary breast cancer even greater if whole-lung XRT

          IMAGING

          • General Features

            • Mammographic Findings

              • Ultrasonographic Findings

                • MR Findings

                  • Imaging Recommendations

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • General Features

                        • Staging, Grading, & Classification

                          CLINICAL ISSUES

                          • Presentation

                            • Demographics

                              • Natural History & Prognosis

                                • Treatment

                                  Selected References

                                  1. Hodgson DC et al: Impact of early breast cancer screening on mortality among young survivors of childhood Hodgkin's lymphoma. J Natl Cancer Inst. 108(7), 2016
                                  2. Zeng L et al: Breast background parenchymal enhancement on screening magnetic resonance imaging in women who received chest radiotherapy for childhood Hodgkin's lymphoma. Acad Radiol. 23(2):168-75, 2016
                                  3. Mariscotti G et al: Mammography and MRI for screening women who underwent chest radiation therapy (lymphoma survivors): recommendations for surveillance from the Italian College of Breast Radiologists by SIRM. Radiol Med. 121(11):834-7, 2016
                                  4. Allen SD et al: Radiologic features of breast cancer after mantle radiation therapy for Hodgkin disease: a study of 230 cases. Radiology. 272(1):73-8, 2014
                                  5. Horst KC et al: Histologic subtypes of breast cancer following radiotherapy for Hodgkin lymphoma. Ann Oncol. 25(4):848-51, 2014
                                  6. Moskowitz CS et al: Breast cancer after chest radiation therapy for childhood cancer. J Clin Oncol. 32(21):2217-23, 2014
                                  7. Freitas V et al: Added cancer yield of breast magnetic resonance imaging screening in women with a prior history of chest radiation therapy. Cancer. 119(3):495-503, 2013
                                  8. Tieu MT et al: Breast cancer detection among young survivors of pediatric Hodgkin lymphoma with screening magnetic resonance imaging. Cancer. 120(16):2507-13, 2014
                                  9. Ng AK et al: Prospective study of the efficacy of breast magnetic resonance imaging and mammographic screening in survivors of Hodgkin lymphoma. J Clin Oncol. 31(18):2282-8, 2013
                                  10. Terenziani M et al: Occurrence of breast cancer after chest wall irradiation for pediatric cancer, as detected by a multimodal screening program. Int J Radiat Oncol Biol Phys. 85(1):35-9, 2013
                                  11. Yahalom J: Evidence-based breast cancer screening guidelines for women who received chest irradiation at a young age. J Clin Oncol. 31(18):2240-2, 2013
                                  12. Haberer S et al: Locoregional treatment for breast carcinoma after Hodgkin's lymphoma: the breast conservation option. Int J Radiat Oncol Biol Phys. 82(2):e145-52, 2012
                                  13. Sung JS et al: Screening breast MR imaging in women with a history of chest irradiation. Radiology. 259(1):65-71, 2011
                                  14. Oeffinger KC et al: Breast cancer surveillance practices among women previously treated with chest radiation for a childhood cancer. JAMA. 301(4):404-14, 2009
                                  15. Kwong A et al: Mammographic screening in women at increased risk of breast cancer after treatment of Hodgkin's disease. Breast J. 14(1):39-48, 2008
                                  16. Lee L et al: Screening mammography for young women treated with supradiaphragmatic radiation for Hodgkin's lymphoma. Ann Oncol. 19(1):62-7, 2008
                                  17. Lord SJ et al: A systematic review of the effectiveness of magnetic resonance imaging (MRI) as an addition to mammography and ultrasound in screening young women at high risk of breast cancer. Eur J Cancer. 43(13):1905-17, 2007
                                  18. Lehman CD et al: Screening women at high risk for breast cancer with mammography and magnetic resonance imaging. Cancer. 103(9):1898-905, 2005
                                  19. Horwich A et al: Second primary breast cancer after Hodgkin's disease. Br J Cancer. 90(2):294-8, 2004
                                  20. Diller L et al: Breast cancer screening in women previously treated for Hodgkin's disease: a prospective cohort study. J Clin Oncol. 20(8):2085-91, 2002
                                  21. Dershaw DD et al: Breast carcinoma in women previously treated for Hodgkin disease: mammographic evaluation. Radiology. 184(2):421-3, 1992
                                  22. Meis JM et al: Hodgkin's disease involving the breast and chest wall. Cancer. 57(9):1859-65, 1986
                                  Related Anatomy
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                                  Related Differential Diagnoses
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                                  References
                                  Tables

                                  Tables

                                  KEY FACTS

                                  • Terminology

                                    • Imaging

                                      • Top Differential Diagnoses

                                        • Clinical Issues

                                          TERMINOLOGY

                                          • Definitions

                                            • High risk of secondary breast cancer after chest XRT, usually for Hodgkin lymphoma (HL), if treated > age 10 & < age 30
                                              • Sequelae of mantle radiation to mediastinum and axillae (lungs shielded); practice ceased in 1990s
                                              • Risk of secondary breast cancer even greater if whole-lung XRT

                                          IMAGING

                                          • General Features

                                            • Mammographic Findings

                                              • Ultrasonographic Findings

                                                • MR Findings

                                                  • Imaging Recommendations

                                                    DIFFERENTIAL DIAGNOSIS

                                                      PATHOLOGY

                                                      • General Features

                                                        • Staging, Grading, & Classification

                                                          CLINICAL ISSUES

                                                          • Presentation

                                                            • Demographics

                                                              • Natural History & Prognosis

                                                                • Treatment

                                                                  Selected References

                                                                  1. Hodgson DC et al: Impact of early breast cancer screening on mortality among young survivors of childhood Hodgkin's lymphoma. J Natl Cancer Inst. 108(7), 2016
                                                                  2. Zeng L et al: Breast background parenchymal enhancement on screening magnetic resonance imaging in women who received chest radiotherapy for childhood Hodgkin's lymphoma. Acad Radiol. 23(2):168-75, 2016
                                                                  3. Mariscotti G et al: Mammography and MRI for screening women who underwent chest radiation therapy (lymphoma survivors): recommendations for surveillance from the Italian College of Breast Radiologists by SIRM. Radiol Med. 121(11):834-7, 2016
                                                                  4. Allen SD et al: Radiologic features of breast cancer after mantle radiation therapy for Hodgkin disease: a study of 230 cases. Radiology. 272(1):73-8, 2014
                                                                  5. Horst KC et al: Histologic subtypes of breast cancer following radiotherapy for Hodgkin lymphoma. Ann Oncol. 25(4):848-51, 2014
                                                                  6. Moskowitz CS et al: Breast cancer after chest radiation therapy for childhood cancer. J Clin Oncol. 32(21):2217-23, 2014
                                                                  7. Freitas V et al: Added cancer yield of breast magnetic resonance imaging screening in women with a prior history of chest radiation therapy. Cancer. 119(3):495-503, 2013
                                                                  8. Tieu MT et al: Breast cancer detection among young survivors of pediatric Hodgkin lymphoma with screening magnetic resonance imaging. Cancer. 120(16):2507-13, 2014
                                                                  9. Ng AK et al: Prospective study of the efficacy of breast magnetic resonance imaging and mammographic screening in survivors of Hodgkin lymphoma. J Clin Oncol. 31(18):2282-8, 2013
                                                                  10. Terenziani M et al: Occurrence of breast cancer after chest wall irradiation for pediatric cancer, as detected by a multimodal screening program. Int J Radiat Oncol Biol Phys. 85(1):35-9, 2013
                                                                  11. Yahalom J: Evidence-based breast cancer screening guidelines for women who received chest irradiation at a young age. J Clin Oncol. 31(18):2240-2, 2013
                                                                  12. Haberer S et al: Locoregional treatment for breast carcinoma after Hodgkin's lymphoma: the breast conservation option. Int J Radiat Oncol Biol Phys. 82(2):e145-52, 2012
                                                                  13. Sung JS et al: Screening breast MR imaging in women with a history of chest irradiation. Radiology. 259(1):65-71, 2011
                                                                  14. Oeffinger KC et al: Breast cancer surveillance practices among women previously treated with chest radiation for a childhood cancer. JAMA. 301(4):404-14, 2009
                                                                  15. Kwong A et al: Mammographic screening in women at increased risk of breast cancer after treatment of Hodgkin's disease. Breast J. 14(1):39-48, 2008
                                                                  16. Lee L et al: Screening mammography for young women treated with supradiaphragmatic radiation for Hodgkin's lymphoma. Ann Oncol. 19(1):62-7, 2008
                                                                  17. Lord SJ et al: A systematic review of the effectiveness of magnetic resonance imaging (MRI) as an addition to mammography and ultrasound in screening young women at high risk of breast cancer. Eur J Cancer. 43(13):1905-17, 2007
                                                                  18. Lehman CD et al: Screening women at high risk for breast cancer with mammography and magnetic resonance imaging. Cancer. 103(9):1898-905, 2005
                                                                  19. Horwich A et al: Second primary breast cancer after Hodgkin's disease. Br J Cancer. 90(2):294-8, 2004
                                                                  20. Diller L et al: Breast cancer screening in women previously treated for Hodgkin's disease: a prospective cohort study. J Clin Oncol. 20(8):2085-91, 2002
                                                                  21. Dershaw DD et al: Breast carcinoma in women previously treated for Hodgkin disease: mammographic evaluation. Radiology. 184(2):421-3, 1992
                                                                  22. Meis JM et al: Hodgkin's disease involving the breast and chest wall. Cancer. 57(9):1859-65, 1986