High risk of secondary breast cancer after chest XRT, usually for Hodgkin lymphoma (HL), if treated > age 10 & < age 30
Sequelae of mantle radiation to mediastinum and axillae (lungs shielded); practice ceased in 1990s
Risk of secondary breast cancer even greater if whole-lung XRT
IMAGING
General Features
Mammographic Findings
Ultrasonographic Findings
MR Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
Selected References
Hodgson DC et al: Impact of early breast cancer screening on mortality among young survivors of childhood Hodgkin's lymphoma. J Natl Cancer Inst. 108(7), 2016
Zeng L et al: Breast background parenchymal enhancement on screening magnetic resonance imaging in women who received chest radiotherapy for childhood Hodgkin's lymphoma. Acad Radiol. 23(2):168-75, 2016
Mariscotti G et al: Mammography and MRI for screening women who underwent chest radiation therapy (lymphoma survivors): recommendations for surveillance from the Italian College of Breast Radiologists by SIRM. Radiol Med. 121(11):834-7, 2016
Allen SD et al: Radiologic features of breast cancer after mantle radiation therapy for Hodgkin disease: a study of 230 cases. Radiology. 272(1):73-8, 2014
Horst KC et al: Histologic subtypes of breast cancer following radiotherapy for Hodgkin lymphoma. Ann Oncol. 25(4):848-51, 2014
Moskowitz CS et al: Breast cancer after chest radiation therapy for childhood cancer. J Clin Oncol. 32(21):2217-23, 2014
Freitas V et al: Added cancer yield of breast magnetic resonance imaging screening in women with a prior history of chest radiation therapy. Cancer. 119(3):495-503, 2013
Tieu MT et al: Breast cancer detection among young survivors of pediatric Hodgkin lymphoma with screening magnetic resonance imaging. Cancer. 120(16):2507-13, 2014
Ng AK et al: Prospective study of the efficacy of breast magnetic resonance imaging and mammographic screening in survivors of Hodgkin lymphoma. J Clin Oncol. 31(18):2282-8, 2013
Terenziani M et al: Occurrence of breast cancer after chest wall irradiation for pediatric cancer, as detected by a multimodal screening program. Int J Radiat Oncol Biol Phys. 85(1):35-9, 2013
Yahalom J: Evidence-based breast cancer screening guidelines for women who received chest irradiation at a young age. J Clin Oncol. 31(18):2240-2, 2013
Haberer S et al: Locoregional treatment for breast carcinoma after Hodgkin's lymphoma: the breast conservation option. Int J Radiat Oncol Biol Phys. 82(2):e145-52, 2012
Sung JS et al: Screening breast MR imaging in women with a history of chest irradiation. Radiology. 259(1):65-71, 2011
Oeffinger KC et al: Breast cancer surveillance practices among women previously treated with chest radiation for a childhood cancer. JAMA. 301(4):404-14, 2009
Kwong A et al: Mammographic screening in women at increased risk of breast cancer after treatment of Hodgkin's disease. Breast J. 14(1):39-48, 2008
Lee L et al: Screening mammography for young women treated with supradiaphragmatic radiation for Hodgkin's lymphoma. Ann Oncol. 19(1):62-7, 2008
Lord SJ et al: A systematic review of the effectiveness of magnetic resonance imaging (MRI) as an addition to mammography and ultrasound in screening young women at high risk of breast cancer. Eur J Cancer. 43(13):1905-17, 2007
Lehman CD et al: Screening women at high risk for breast cancer with mammography and magnetic resonance imaging. Cancer. 103(9):1898-905, 2005
Horwich A et al: Second primary breast cancer after Hodgkin's disease. Br J Cancer. 90(2):294-8, 2004
Diller L et al: Breast cancer screening in women previously treated for Hodgkin's disease: a prospective cohort study. J Clin Oncol. 20(8):2085-91, 2002
Dershaw DD et al: Breast carcinoma in women previously treated for Hodgkin disease: mammographic evaluation. Radiology. 184(2):421-3, 1992
Meis JM et al: Hodgkin's disease involving the breast and chest wall. Cancer. 57(9):1859-65, 1986
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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Clinical Issues
TERMINOLOGY
Definitions
High risk of secondary breast cancer after chest XRT, usually for Hodgkin lymphoma (HL), if treated > age 10 & < age 30
Sequelae of mantle radiation to mediastinum and axillae (lungs shielded); practice ceased in 1990s
Risk of secondary breast cancer even greater if whole-lung XRT
IMAGING
General Features
Mammographic Findings
Ultrasonographic Findings
MR Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
Selected References
Hodgson DC et al: Impact of early breast cancer screening on mortality among young survivors of childhood Hodgkin's lymphoma. J Natl Cancer Inst. 108(7), 2016
Zeng L et al: Breast background parenchymal enhancement on screening magnetic resonance imaging in women who received chest radiotherapy for childhood Hodgkin's lymphoma. Acad Radiol. 23(2):168-75, 2016
Mariscotti G et al: Mammography and MRI for screening women who underwent chest radiation therapy (lymphoma survivors): recommendations for surveillance from the Italian College of Breast Radiologists by SIRM. Radiol Med. 121(11):834-7, 2016
Allen SD et al: Radiologic features of breast cancer after mantle radiation therapy for Hodgkin disease: a study of 230 cases. Radiology. 272(1):73-8, 2014
Horst KC et al: Histologic subtypes of breast cancer following radiotherapy for Hodgkin lymphoma. Ann Oncol. 25(4):848-51, 2014
Moskowitz CS et al: Breast cancer after chest radiation therapy for childhood cancer. J Clin Oncol. 32(21):2217-23, 2014
Freitas V et al: Added cancer yield of breast magnetic resonance imaging screening in women with a prior history of chest radiation therapy. Cancer. 119(3):495-503, 2013
Tieu MT et al: Breast cancer detection among young survivors of pediatric Hodgkin lymphoma with screening magnetic resonance imaging. Cancer. 120(16):2507-13, 2014
Ng AK et al: Prospective study of the efficacy of breast magnetic resonance imaging and mammographic screening in survivors of Hodgkin lymphoma. J Clin Oncol. 31(18):2282-8, 2013
Terenziani M et al: Occurrence of breast cancer after chest wall irradiation for pediatric cancer, as detected by a multimodal screening program. Int J Radiat Oncol Biol Phys. 85(1):35-9, 2013
Yahalom J: Evidence-based breast cancer screening guidelines for women who received chest irradiation at a young age. J Clin Oncol. 31(18):2240-2, 2013
Haberer S et al: Locoregional treatment for breast carcinoma after Hodgkin's lymphoma: the breast conservation option. Int J Radiat Oncol Biol Phys. 82(2):e145-52, 2012
Sung JS et al: Screening breast MR imaging in women with a history of chest irradiation. Radiology. 259(1):65-71, 2011
Oeffinger KC et al: Breast cancer surveillance practices among women previously treated with chest radiation for a childhood cancer. JAMA. 301(4):404-14, 2009
Kwong A et al: Mammographic screening in women at increased risk of breast cancer after treatment of Hodgkin's disease. Breast J. 14(1):39-48, 2008
Lee L et al: Screening mammography for young women treated with supradiaphragmatic radiation for Hodgkin's lymphoma. Ann Oncol. 19(1):62-7, 2008
Lord SJ et al: A systematic review of the effectiveness of magnetic resonance imaging (MRI) as an addition to mammography and ultrasound in screening young women at high risk of breast cancer. Eur J Cancer. 43(13):1905-17, 2007
Lehman CD et al: Screening women at high risk for breast cancer with mammography and magnetic resonance imaging. Cancer. 103(9):1898-905, 2005
Horwich A et al: Second primary breast cancer after Hodgkin's disease. Br J Cancer. 90(2):294-8, 2004
Diller L et al: Breast cancer screening in women previously treated for Hodgkin's disease: a prospective cohort study. J Clin Oncol. 20(8):2085-91, 2002
Dershaw DD et al: Breast carcinoma in women previously treated for Hodgkin disease: mammographic evaluation. Radiology. 184(2):421-3, 1992
Meis JM et al: Hodgkin's disease involving the breast and chest wall. Cancer. 57(9):1859-65, 1986
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