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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Abbreviations
Progressive supranuclear palsy (PSP)
Synonyms
Steele-Richardson-Olszewski syndrome
Definitions
Atypical parkinsonian syndrome and neurodegenerative disease characterized by vertical supranuclear gaze palsy, postural instability with unexplained falls, akinesia, and cognitive dysfunction
IMAGING
General Features
Imaging Recommendations
CT Findings
MR Findings
Nuclear Medicine Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
Variant PSP Syndrome
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Agarwal S et al: Progressive supranuclear palsy. StatPearls. 2020
Eraslan C et al: MRI evaluation of progressive supranuclear palsy: differentiation from Parkinson's disease and multiple system atrophy. Neurol Res. 41(2):110-7, 2019
Giagkou N et al: Progressive supranuclear palsy. Int Rev Neurobiol. 149:49-86, 2019
Grimm MJ et al: How to apply the movement disorder society criteria for diagnosis of progressive supranuclear palsy. Mov Disord. 34(8):1228-32, 2019
Smith MD et al: Imaging in the diagnosis of progressive supranuclear palsy. J Neurol. 266(2):545-7, 2019
Talai AS et al: Improved automatic morphology-based classification of parkinson's disease and progressive supranuclear palsy. Clin Neuroradiol. 29(4):605-14, 2019
Krismer F et al: Diagnosis of PSP-P: can a newly developed MRPI make the difference? Parkinsonism Relat Disord. 54:1-2, 2018
Quattrone A et al: A new MR imaging index for differentiation of progressive supranuclear palsy-parkinsonism from Parkinson's disease. Parkinsonism Relat Disord. 54:3-8, 2018
Booth TC et al: The role of functional dopamine-transporter SPECT imaging in parkinsonian syndromes, part 1. AJNR Am J Neuroradiol. 36(2):229-35, 2015
Booth TC et al: The role of functional dopamine-transporter SPECT imaging in parkinsonian syndromes, part 2. AJNR Am J Neuroradiol. 36(2):236-44, 2015
Josephs KA: Key emerging issues in progressive supranuclear palsy and corticobasal degeneration. J Neurol. 262(3):783-8, 2015
Broski SM et al: Structural and functional imaging in parkinsonian syndromes. Radiographics. 34(5):1273-92, 2014
Colosimo C et al: Fifty years of progressive supranuclear palsy. J Neurol Neurosurg Psychiatry. 85(8):938-44, 2014
Stamelou M et al: Atypical parkinsonism: an update. Curr Opin Neurol. 26(4):401-5, 2013
Williams DR et al: Parkinsonian syndromes. Continuum (Minneap Minn). 19(5 Movement Disorders):1189-212, 2013
Williams DR et al: Progressive supranuclear palsy: clinicopathological concepts and diagnostic challenges. Lancet Neurol. 8(3):270-9, 2009
Quattrone A et al: MR imaging index for differentiation of progressive supranuclear palsy from Parkinson disease and the Parkinson variant of multiple system atrophy. Radiology. 246(1):214-21, 2008
Rizzo G et al: Diffusion-weighted brain imaging study of patients with clinical diagnosis of corticobasal degeneration, progressive supranuclear palsy and Parkinson's disease. Brain. 131(Pt 10):2690-700, 2008
Oba H et al: New and reliable MRI diagnosis for progressive supranuclear palsy. Neurology. 64(12):2050-5, 2005
Adachi M et al: Morning glory sign: a particular MR finding in progressive supranuclear palsy. Magn Reson Med Sci. 3(3):125-32, 2004
Righini A et al: MR imaging of the superior profile of the midbrain: differential diagnosis between progressive supranuclear palsy and Parkinson disease. AJNR Am J Neuroradiol. 25(6):927-32, 2004
Related Anatomy
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Related Differential Diagnoses
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Abbreviations
Progressive supranuclear palsy (PSP)
Synonyms
Steele-Richardson-Olszewski syndrome
Definitions
Atypical parkinsonian syndrome and neurodegenerative disease characterized by vertical supranuclear gaze palsy, postural instability with unexplained falls, akinesia, and cognitive dysfunction
IMAGING
General Features
Imaging Recommendations
CT Findings
MR Findings
Nuclear Medicine Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
Variant PSP Syndrome
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Agarwal S et al: Progressive supranuclear palsy. StatPearls. 2020
Eraslan C et al: MRI evaluation of progressive supranuclear palsy: differentiation from Parkinson's disease and multiple system atrophy. Neurol Res. 41(2):110-7, 2019
Giagkou N et al: Progressive supranuclear palsy. Int Rev Neurobiol. 149:49-86, 2019
Grimm MJ et al: How to apply the movement disorder society criteria for diagnosis of progressive supranuclear palsy. Mov Disord. 34(8):1228-32, 2019
Smith MD et al: Imaging in the diagnosis of progressive supranuclear palsy. J Neurol. 266(2):545-7, 2019
Talai AS et al: Improved automatic morphology-based classification of parkinson's disease and progressive supranuclear palsy. Clin Neuroradiol. 29(4):605-14, 2019
Krismer F et al: Diagnosis of PSP-P: can a newly developed MRPI make the difference? Parkinsonism Relat Disord. 54:1-2, 2018
Quattrone A et al: A new MR imaging index for differentiation of progressive supranuclear palsy-parkinsonism from Parkinson's disease. Parkinsonism Relat Disord. 54:3-8, 2018
Booth TC et al: The role of functional dopamine-transporter SPECT imaging in parkinsonian syndromes, part 1. AJNR Am J Neuroradiol. 36(2):229-35, 2015
Booth TC et al: The role of functional dopamine-transporter SPECT imaging in parkinsonian syndromes, part 2. AJNR Am J Neuroradiol. 36(2):236-44, 2015
Josephs KA: Key emerging issues in progressive supranuclear palsy and corticobasal degeneration. J Neurol. 262(3):783-8, 2015
Broski SM et al: Structural and functional imaging in parkinsonian syndromes. Radiographics. 34(5):1273-92, 2014
Colosimo C et al: Fifty years of progressive supranuclear palsy. J Neurol Neurosurg Psychiatry. 85(8):938-44, 2014
Stamelou M et al: Atypical parkinsonism: an update. Curr Opin Neurol. 26(4):401-5, 2013
Williams DR et al: Parkinsonian syndromes. Continuum (Minneap Minn). 19(5 Movement Disorders):1189-212, 2013
Williams DR et al: Progressive supranuclear palsy: clinicopathological concepts and diagnostic challenges. Lancet Neurol. 8(3):270-9, 2009
Quattrone A et al: MR imaging index for differentiation of progressive supranuclear palsy from Parkinson disease and the Parkinson variant of multiple system atrophy. Radiology. 246(1):214-21, 2008
Rizzo G et al: Diffusion-weighted brain imaging study of patients with clinical diagnosis of corticobasal degeneration, progressive supranuclear palsy and Parkinson's disease. Brain. 131(Pt 10):2690-700, 2008
Oba H et al: New and reliable MRI diagnosis for progressive supranuclear palsy. Neurology. 64(12):2050-5, 2005
Adachi M et al: Morning glory sign: a particular MR finding in progressive supranuclear palsy. Magn Reson Med Sci. 3(3):125-32, 2004
Righini A et al: MR imaging of the superior profile of the midbrain: differential diagnosis between progressive supranuclear palsy and Parkinson disease. AJNR Am J Neuroradiol. 25(6):927-32, 2004
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