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Progressive Supranuclear Palsy
Santhosh Gaddikeri, MD; Miral D. Jhaveri, MD, MBA
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Abbreviations

              • Progressive supranuclear palsy (PSP)
            • Synonyms

              • Steele-Richardson-Olszewski syndrome
            • Definitions

              • Atypical parkinsonian syndrome and neurodegenerative disease characterized by vertical supranuclear gaze palsy, postural instability with unexplained falls, akinesia, and cognitive dysfunction

            IMAGING

            • General Features

              • Imaging Recommendations

                • CT Findings

                  • MR Findings

                    • Nuclear Medicine Findings

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Gross Pathologic & Surgical Features

                            • Microscopic Features

                              CLINICAL ISSUES

                              • Presentation

                                • Demographics

                                  • Natural History & Prognosis

                                    • Treatment

                                      • Variant PSP Syndrome

                                        DIAGNOSTIC CHECKLIST

                                        • Consider

                                          • Image Interpretation Pearls

                                            Selected References

                                            1. Agarwal S et al: Progressive supranuclear palsy. StatPearls. 2020
                                            2. Eraslan C et al: MRI evaluation of progressive supranuclear palsy: differentiation from Parkinson's disease and multiple system atrophy. Neurol Res. 41(2):110-7, 2019
                                            3. Giagkou N et al: Progressive supranuclear palsy. Int Rev Neurobiol. 149:49-86, 2019
                                            4. Grimm MJ et al: How to apply the movement disorder society criteria for diagnosis of progressive supranuclear palsy. Mov Disord. 34(8):1228-32, 2019
                                            5. Smith MD et al: Imaging in the diagnosis of progressive supranuclear palsy. J Neurol. 266(2):545-7, 2019
                                            6. Talai AS et al: Improved automatic morphology-based classification of parkinson's disease and progressive supranuclear palsy. Clin Neuroradiol. 29(4):605-14, 2019
                                            7. Krismer F et al: Diagnosis of PSP-P: can a newly developed MRPI make the difference? Parkinsonism Relat Disord. 54:1-2, 2018
                                            8. Quattrone A et al: A new MR imaging index for differentiation of progressive supranuclear palsy-parkinsonism from Parkinson's disease. Parkinsonism Relat Disord. 54:3-8, 2018
                                            9. Booth TC et al: The role of functional dopamine-transporter SPECT imaging in parkinsonian syndromes, part 1. AJNR Am J Neuroradiol. 36(2):229-35, 2015
                                            10. Booth TC et al: The role of functional dopamine-transporter SPECT imaging in parkinsonian syndromes, part 2. AJNR Am J Neuroradiol. 36(2):236-44, 2015
                                            11. Josephs KA: Key emerging issues in progressive supranuclear palsy and corticobasal degeneration. J Neurol. 262(3):783-8, 2015
                                            12. Broski SM et al: Structural and functional imaging in parkinsonian syndromes. Radiographics. 34(5):1273-92, 2014
                                            13. Colosimo C et al: Fifty years of progressive supranuclear palsy. J Neurol Neurosurg Psychiatry. 85(8):938-44, 2014
                                            14. Golbe LI: Progressive supranuclear palsy. Semin Neurol. 34(2):151-9, 2014
                                            15. Stamelou M et al: Atypical parkinsonism: an update. Curr Opin Neurol. 26(4):401-5, 2013
                                            16. Williams DR et al: Parkinsonian syndromes. Continuum (Minneap Minn). 19(5 Movement Disorders):1189-212, 2013
                                            17. Williams DR et al: Progressive supranuclear palsy: clinicopathological concepts and diagnostic challenges. Lancet Neurol. 8(3):270-9, 2009
                                            18. Quattrone A et al: MR imaging index for differentiation of progressive supranuclear palsy from Parkinson disease and the Parkinson variant of multiple system atrophy. Radiology. 246(1):214-21, 2008
                                            19. Rizzo G et al: Diffusion-weighted brain imaging study of patients with clinical diagnosis of corticobasal degeneration, progressive supranuclear palsy and Parkinson's disease. Brain. 131(Pt 10):2690-700, 2008
                                            20. Oba H et al: New and reliable MRI diagnosis for progressive supranuclear palsy. Neurology. 64(12):2050-5, 2005
                                            21. Adachi M et al: Morning glory sign: a particular MR finding in progressive supranuclear palsy. Magn Reson Med Sci. 3(3):125-32, 2004
                                            22. Righini A et al: MR imaging of the superior profile of the midbrain: differential diagnosis between progressive supranuclear palsy and Parkinson disease. AJNR Am J Neuroradiol. 25(6):927-32, 2004
                                            Related Anatomy
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                                            Related Differential Diagnoses
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                                            References
                                            Tables

                                            Tables

                                            KEY FACTS

                                            • Terminology

                                              • Imaging

                                                • Top Differential Diagnoses

                                                  • Pathology

                                                    • Clinical Issues

                                                      TERMINOLOGY

                                                      • Abbreviations

                                                        • Progressive supranuclear palsy (PSP)
                                                      • Synonyms

                                                        • Steele-Richardson-Olszewski syndrome
                                                      • Definitions

                                                        • Atypical parkinsonian syndrome and neurodegenerative disease characterized by vertical supranuclear gaze palsy, postural instability with unexplained falls, akinesia, and cognitive dysfunction

                                                      IMAGING

                                                      • General Features

                                                        • Imaging Recommendations

                                                          • CT Findings

                                                            • MR Findings

                                                              • Nuclear Medicine Findings

                                                                DIFFERENTIAL DIAGNOSIS

                                                                  PATHOLOGY

                                                                  • General Features

                                                                    • Gross Pathologic & Surgical Features

                                                                      • Microscopic Features

                                                                        CLINICAL ISSUES

                                                                        • Presentation

                                                                          • Demographics

                                                                            • Natural History & Prognosis

                                                                              • Treatment

                                                                                • Variant PSP Syndrome

                                                                                  DIAGNOSTIC CHECKLIST

                                                                                  • Consider

                                                                                    • Image Interpretation Pearls

                                                                                      Selected References

                                                                                      1. Agarwal S et al: Progressive supranuclear palsy. StatPearls. 2020
                                                                                      2. Eraslan C et al: MRI evaluation of progressive supranuclear palsy: differentiation from Parkinson's disease and multiple system atrophy. Neurol Res. 41(2):110-7, 2019
                                                                                      3. Giagkou N et al: Progressive supranuclear palsy. Int Rev Neurobiol. 149:49-86, 2019
                                                                                      4. Grimm MJ et al: How to apply the movement disorder society criteria for diagnosis of progressive supranuclear palsy. Mov Disord. 34(8):1228-32, 2019
                                                                                      5. Smith MD et al: Imaging in the diagnosis of progressive supranuclear palsy. J Neurol. 266(2):545-7, 2019
                                                                                      6. Talai AS et al: Improved automatic morphology-based classification of parkinson's disease and progressive supranuclear palsy. Clin Neuroradiol. 29(4):605-14, 2019
                                                                                      7. Krismer F et al: Diagnosis of PSP-P: can a newly developed MRPI make the difference? Parkinsonism Relat Disord. 54:1-2, 2018
                                                                                      8. Quattrone A et al: A new MR imaging index for differentiation of progressive supranuclear palsy-parkinsonism from Parkinson's disease. Parkinsonism Relat Disord. 54:3-8, 2018
                                                                                      9. Booth TC et al: The role of functional dopamine-transporter SPECT imaging in parkinsonian syndromes, part 1. AJNR Am J Neuroradiol. 36(2):229-35, 2015
                                                                                      10. Booth TC et al: The role of functional dopamine-transporter SPECT imaging in parkinsonian syndromes, part 2. AJNR Am J Neuroradiol. 36(2):236-44, 2015
                                                                                      11. Josephs KA: Key emerging issues in progressive supranuclear palsy and corticobasal degeneration. J Neurol. 262(3):783-8, 2015
                                                                                      12. Broski SM et al: Structural and functional imaging in parkinsonian syndromes. Radiographics. 34(5):1273-92, 2014
                                                                                      13. Colosimo C et al: Fifty years of progressive supranuclear palsy. J Neurol Neurosurg Psychiatry. 85(8):938-44, 2014
                                                                                      14. Golbe LI: Progressive supranuclear palsy. Semin Neurol. 34(2):151-9, 2014
                                                                                      15. Stamelou M et al: Atypical parkinsonism: an update. Curr Opin Neurol. 26(4):401-5, 2013
                                                                                      16. Williams DR et al: Parkinsonian syndromes. Continuum (Minneap Minn). 19(5 Movement Disorders):1189-212, 2013
                                                                                      17. Williams DR et al: Progressive supranuclear palsy: clinicopathological concepts and diagnostic challenges. Lancet Neurol. 8(3):270-9, 2009
                                                                                      18. Quattrone A et al: MR imaging index for differentiation of progressive supranuclear palsy from Parkinson disease and the Parkinson variant of multiple system atrophy. Radiology. 246(1):214-21, 2008
                                                                                      19. Rizzo G et al: Diffusion-weighted brain imaging study of patients with clinical diagnosis of corticobasal degeneration, progressive supranuclear palsy and Parkinson's disease. Brain. 131(Pt 10):2690-700, 2008
                                                                                      20. Oba H et al: New and reliable MRI diagnosis for progressive supranuclear palsy. Neurology. 64(12):2050-5, 2005
                                                                                      21. Adachi M et al: Morning glory sign: a particular MR finding in progressive supranuclear palsy. Magn Reson Med Sci. 3(3):125-32, 2004
                                                                                      22. Righini A et al: MR imaging of the superior profile of the midbrain: differential diagnosis between progressive supranuclear palsy and Parkinson disease. AJNR Am J Neuroradiol. 25(6):927-32, 2004