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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Abbreviations
- Amyloid light chain (AL)
- Serum amyloid A (AA)
- Transthyretin amyloid (ATTR)
- Amyloid β-2 microglobulin (Aβ2M)
- Wild-type transthyretin amyloid (ATTRwt)
- Lysozyme amyloid (ALys)
- Gelsolin amyloid (AGel)
Definitions
- Deposition of abnormal insoluble proteins within tissue
- Localized vs. systemic
- Localized disease or disease manifesting primarily in one organ vs. systemic disease
- Localized to respiratory tract: Primarily AL
- Systemic: Associated with AL, AA, ATTR, etc.
- Primary: Associated with primary cell dyscrasias
- Secondary: Associated with chronic infections or inflammatory disorders
- Systemic AL: Formerly known as primary amyloidosis
- Terms primary and secondary amyloidosis refer to chemical make-up of abnormalities
- Primary: i.e., AL amyloidosis
- Secondary: i.e., AA amyloidosis
- Localized vs. systemic
- Deposition of abnormal insoluble proteins within tissue
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
- Stern LK et al: Updates in cardiac amyloidosis diagnosis and treatment. Curr Oncol Rep. 23(4):47, 2021
- Wu CW et al: Sjögren's syndrome with nodular pulmonary amyloidosis. Respirol Case Rep. 9(1):e00699, 2021
- Brandelik SC et al: CT features in amyloidosis of the respiratory system - comprehensive analysis in a tertiary referral center cohort. Eur J Radiol. 129:109123, 2020
- Milani P et al: The lung in amyloidosis. Eur Respir Rev. 26(145), 2017
- Schelbert EB et al: State of the art: clinical applications of cardiac T1 mapping. Radiology. 278(3):658-76, 2016
- Wechalekar AD et al: Systemic amyloidosis. Lancet. 387(10038):2641-54, 2016
- Czeyda-Pommersheim F et al: Amyloidosis: modern cross-sectional imaging. Radiographics. 35(5):1381-92, 2015
- Park MA et al: 18F-florbetapir binds specifically to myocardial light chain and transthyretin amyloid deposits: autoradiography study. Circ Cardiovasc Imaging. 8(8), 2015
- Baqir M et al: Amyloid-associated cystic lung disease in primary Sjögren's syndrome. Respir Med. 107(4):616-21, 2013
- De Smet K et al: MRI in the assessment of non ischemic myocardial diseases. Eur J Radiol. 81(7):1546-8, 2012
- Kang J et al: Manifestations of systemic diseases on thoracic imaging. Curr Probl Diagn Radiol. 39(6):247-61, 2010
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Related Differential Diagnoses
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Abbreviations
- Amyloid light chain (AL)
- Serum amyloid A (AA)
- Transthyretin amyloid (ATTR)
- Amyloid β-2 microglobulin (Aβ2M)
- Wild-type transthyretin amyloid (ATTRwt)
- Lysozyme amyloid (ALys)
- Gelsolin amyloid (AGel)
Definitions
- Deposition of abnormal insoluble proteins within tissue
- Localized vs. systemic
- Localized disease or disease manifesting primarily in one organ vs. systemic disease
- Localized to respiratory tract: Primarily AL
- Systemic: Associated with AL, AA, ATTR, etc.
- Primary: Associated with primary cell dyscrasias
- Secondary: Associated with chronic infections or inflammatory disorders
- Systemic AL: Formerly known as primary amyloidosis
- Terms primary and secondary amyloidosis refer to chemical make-up of abnormalities
- Primary: i.e., AL amyloidosis
- Secondary: i.e., AA amyloidosis
- Localized vs. systemic
- Deposition of abnormal insoluble proteins within tissue
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
- Stern LK et al: Updates in cardiac amyloidosis diagnosis and treatment. Curr Oncol Rep. 23(4):47, 2021
- Wu CW et al: Sjögren's syndrome with nodular pulmonary amyloidosis. Respirol Case Rep. 9(1):e00699, 2021
- Brandelik SC et al: CT features in amyloidosis of the respiratory system - comprehensive analysis in a tertiary referral center cohort. Eur J Radiol. 129:109123, 2020
- Milani P et al: The lung in amyloidosis. Eur Respir Rev. 26(145), 2017
- Schelbert EB et al: State of the art: clinical applications of cardiac T1 mapping. Radiology. 278(3):658-76, 2016
- Wechalekar AD et al: Systemic amyloidosis. Lancet. 387(10038):2641-54, 2016
- Czeyda-Pommersheim F et al: Amyloidosis: modern cross-sectional imaging. Radiographics. 35(5):1381-92, 2015
- Park MA et al: 18F-florbetapir binds specifically to myocardial light chain and transthyretin amyloid deposits: autoradiography study. Circ Cardiovasc Imaging. 8(8), 2015
- Baqir M et al: Amyloid-associated cystic lung disease in primary Sjögren's syndrome. Respir Med. 107(4):616-21, 2013
- De Smet K et al: MRI in the assessment of non ischemic myocardial diseases. Eur J Radiol. 81(7):1546-8, 2012
- Kang J et al: Manifestations of systemic diseases on thoracic imaging. Curr Probl Diagn Radiol. 39(6):247-61, 2010
