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Pulmonary Langerhans Cell Histiocytosis
Tyler H. Ternes, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Abbreviations

                • Pulmonary Langerhans cell histiocytosis (PLCH)
              • Definitions

                • Peribronchiolar infiltration of stellate nodules that contain Langerhans cells

              IMAGING

              • General Features

                • Radiographic Findings

                  • CT Findings

                    • Nuclear Medicine Findings

                      • Imaging Recommendations

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Gross Pathologic & Surgical Features

                              • Microscopic Features

                                CLINICAL ISSUES

                                • Presentation

                                  • Demographics

                                    • Diagnosis

                                      • Natural History & Prognosis

                                        • Treatment

                                          DIAGNOSTIC CHECKLIST

                                          • Consider

                                            • Image Interpretation Pearls

                                              Selected References

                                              1. Radzikowska E: Update on pulmonary Langerhans cell histiocytosis. Front Med (Lausanne). 7:582581, 2020
                                              2. Shaw B et al: Pulmonary Langerhans cell histiocytosis. Semin Respir Crit Care Med. 41(2):269-79, 2020
                                              3. Lorillon G et al: How I manage pulmonary Langerhans cell histiocytosis. Eur Respir Rev. 26(145), 2017
                                              4. Vassallo R et al: Current understanding and management of pulmonary Langerhans cell histiocytosis. Thorax. 72(10):937-45, 2017
                                              5. Raoof S et al: Cystic lung diseases: algorithmic approach. Chest. 150(4):945-65, 2016
                                              6. Castoldi MC et al: Pulmonary Langerhans cell histiocytosis: the many faces of presentation at initial CT scan. Insights Imaging. 5(4):483-92, 2014
                                              7. Seaman DM et al: Diffuse cystic lung disease at high-resolution CT. AJR Am J Roentgenol. 196(6):1305-11, 2011
                                              8. Seely JM et al: Pulmonary Langerhans cell histiocytosis: a comparative study of computed tomography in children and adults. J Thorac Imaging. 27(1):65-70, 2010
                                              9. Galvin JR et al: Smoking-related lung disease. J Thorac Imaging. 24(4):274-84, 2009
                                              10. Krajicek BJ et al: Abnormal fluorodeoxyglucose PET in pulmonary Langerhans cell histiocytosis. Chest. 135(6):1542-9, 2009
                                              11. Attili AK et al: Smoking-related interstitial lung disease: radiologic-clinical-pathologic correlation. Radiographics. 28(5):1383-96; discussion 1396-8, 2008
                                              12. Abbott GF et al: From the archives of the AFIP: pulmonary Langerhans cell histiocytosis. Radiographics. 24(3):821-41, 2004
                                              13. Vassallo R et al: Pulmonary Langerhans'-cell histiocytosis. N Engl J Med. 342(26):1969-78, 2000
                                              14. Brauner MW et al: Pulmonary Langerhans cell histiocytosis: evolution of lesions on CT scans. Radiology. 204(2):497-502, 1997
                                              15. Moore AD et al: Pulmonary histiocytosis X: comparison of radiographic and CT findings. Radiology. 172(1):249-54, 1989
                                              Related Anatomy
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                                              Related Differential Diagnoses
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                                              References
                                              Tables

                                              Tables

                                              KEY FACTS

                                              • Terminology

                                                • Imaging

                                                  • Top Differential Diagnoses

                                                    • Pathology

                                                      • Clinical Issues

                                                        • Diagnostic Checklist

                                                          TERMINOLOGY

                                                          • Abbreviations

                                                            • Pulmonary Langerhans cell histiocytosis (PLCH)
                                                          • Definitions

                                                            • Peribronchiolar infiltration of stellate nodules that contain Langerhans cells

                                                          IMAGING

                                                          • General Features

                                                            • Radiographic Findings

                                                              • CT Findings

                                                                • Nuclear Medicine Findings

                                                                  • Imaging Recommendations

                                                                    DIFFERENTIAL DIAGNOSIS

                                                                      PATHOLOGY

                                                                      • General Features

                                                                        • Gross Pathologic & Surgical Features

                                                                          • Microscopic Features

                                                                            CLINICAL ISSUES

                                                                            • Presentation

                                                                              • Demographics

                                                                                • Diagnosis

                                                                                  • Natural History & Prognosis

                                                                                    • Treatment

                                                                                      DIAGNOSTIC CHECKLIST

                                                                                      • Consider

                                                                                        • Image Interpretation Pearls

                                                                                          Selected References

                                                                                          1. Radzikowska E: Update on pulmonary Langerhans cell histiocytosis. Front Med (Lausanne). 7:582581, 2020
                                                                                          2. Shaw B et al: Pulmonary Langerhans cell histiocytosis. Semin Respir Crit Care Med. 41(2):269-79, 2020
                                                                                          3. Lorillon G et al: How I manage pulmonary Langerhans cell histiocytosis. Eur Respir Rev. 26(145), 2017
                                                                                          4. Vassallo R et al: Current understanding and management of pulmonary Langerhans cell histiocytosis. Thorax. 72(10):937-45, 2017
                                                                                          5. Raoof S et al: Cystic lung diseases: algorithmic approach. Chest. 150(4):945-65, 2016
                                                                                          6. Castoldi MC et al: Pulmonary Langerhans cell histiocytosis: the many faces of presentation at initial CT scan. Insights Imaging. 5(4):483-92, 2014
                                                                                          7. Seaman DM et al: Diffuse cystic lung disease at high-resolution CT. AJR Am J Roentgenol. 196(6):1305-11, 2011
                                                                                          8. Seely JM et al: Pulmonary Langerhans cell histiocytosis: a comparative study of computed tomography in children and adults. J Thorac Imaging. 27(1):65-70, 2010
                                                                                          9. Galvin JR et al: Smoking-related lung disease. J Thorac Imaging. 24(4):274-84, 2009
                                                                                          10. Krajicek BJ et al: Abnormal fluorodeoxyglucose PET in pulmonary Langerhans cell histiocytosis. Chest. 135(6):1542-9, 2009
                                                                                          11. Attili AK et al: Smoking-related interstitial lung disease: radiologic-clinical-pathologic correlation. Radiographics. 28(5):1383-96; discussion 1396-8, 2008
                                                                                          12. Abbott GF et al: From the archives of the AFIP: pulmonary Langerhans cell histiocytosis. Radiographics. 24(3):821-41, 2004
                                                                                          13. Vassallo R et al: Pulmonary Langerhans'-cell histiocytosis. N Engl J Med. 342(26):1969-78, 2000
                                                                                          14. Brauner MW et al: Pulmonary Langerhans cell histiocytosis: evolution of lesions on CT scans. Radiology. 204(2):497-502, 1997
                                                                                          15. Moore AD et al: Pulmonary histiocytosis X: comparison of radiographic and CT findings. Radiology. 172(1):249-54, 1989