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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
- Primary pulmonary lymphoma (PPL)
- Non-Hodgkin lymphoma (NHL)
- Mucosa-associated lymphoid tissue (MALT) lymphoma
- Diffuse large B-cell lymphoma (DLBCL)
- Lymphomatoid granulomatosis (LG)
- Hodgkin lymphoma (HL)
- Non-Hodgkin lymphoma (NHL)
- Secondary pulmonary lymphoma (SPL)
- Primary pulmonary lymphoma (PPL)
Synonyms
- Low-grade primary pulmonary B-cell lymphoma
- MALT lymphoma
Definitions
- PPL
- Pulmonary clonal lymphoid proliferation in patient with no detectable extrapulmonary lymphoma for at least 3 months after initial diagnosis
- Represents 0.5% of primary lung malignancies
- Almost all cases of PPL are NHL
- ~ 70 cases of primary pulmonary HL reported
- Represents only 3-4% of cases of primary extranodal NHL
- Most common subtypes: MALT lymphoma, high-grade DLBCL, LG
- MALT lymphoma: Low-grade extranodal B-cell lymphoma, represents majority of cases of PPL
- Uncommon subtypes: Pulmonary intravascular lymphoma, primary pulmonary plasmacytoma
- SPL
- Common as manifestation of systemic involvement by HL and NHL
- Lung involvement rate higher in HL (85%) than in NHL (24%), but NHL is far more common and represents up to 90% of all SPL
- Mechanisms of lung involvement
- Invasion from hilar or mediastinal lymph nodes
- Hematogeneous or lymphatic dissemination
- PPL
IMAGING
General Features
Radiographic Findings
CT Findings
Imaging Recommendations
Nuclear Medicine Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Microscopic Features
CLINICAL ISSUES
Demographics
Mucosa-Associated Lymphoid Tissue Lymphoma
High-Grade B-Cell Non-Hodgkin Lymphoma
Lymphomatoid Granulomatosis
Primary Pulmonary Plasmacytoma
Pulmonary Intravascular Lymphoma
DIAGNOSTIC CHECKLIST
Consider
Selected References
- Angirish B et al: Pulmonary manifestations of lymphoma: A pictorial essay. Lung India. 37(3):263-7, 2020
- Cozzi D et al: Primary pulmonary lymphoma: imaging findings in 30 cases. Radiol Med. 124(12):1262-9, 2019
- Deng W et al: Pulmonary MALT Lymphoma has variable features on CT. Sci Rep. 9(1):8657, 2019
- Yao D et al: Clinical and misdiagnosed analysis of primary pulmonary lymphoma: a retrospective study. BMC Cancer. 18(1):281, 2018
- Bligh MP et al: Spectrum of CT findings in thoracic extranodal non-Hodgkin lymphoma. Radiographics. 37(2):439-61, 2017
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
- Primary pulmonary lymphoma (PPL)
- Non-Hodgkin lymphoma (NHL)
- Mucosa-associated lymphoid tissue (MALT) lymphoma
- Diffuse large B-cell lymphoma (DLBCL)
- Lymphomatoid granulomatosis (LG)
- Hodgkin lymphoma (HL)
- Non-Hodgkin lymphoma (NHL)
- Secondary pulmonary lymphoma (SPL)
- Primary pulmonary lymphoma (PPL)
Synonyms
- Low-grade primary pulmonary B-cell lymphoma
- MALT lymphoma
Definitions
- PPL
- Pulmonary clonal lymphoid proliferation in patient with no detectable extrapulmonary lymphoma for at least 3 months after initial diagnosis
- Represents 0.5% of primary lung malignancies
- Almost all cases of PPL are NHL
- ~ 70 cases of primary pulmonary HL reported
- Represents only 3-4% of cases of primary extranodal NHL
- Most common subtypes: MALT lymphoma, high-grade DLBCL, LG
- MALT lymphoma: Low-grade extranodal B-cell lymphoma, represents majority of cases of PPL
- Uncommon subtypes: Pulmonary intravascular lymphoma, primary pulmonary plasmacytoma
- SPL
- Common as manifestation of systemic involvement by HL and NHL
- Lung involvement rate higher in HL (85%) than in NHL (24%), but NHL is far more common and represents up to 90% of all SPL
- Mechanisms of lung involvement
- Invasion from hilar or mediastinal lymph nodes
- Hematogeneous or lymphatic dissemination
- PPL
IMAGING
General Features
Radiographic Findings
CT Findings
Imaging Recommendations
Nuclear Medicine Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Microscopic Features
CLINICAL ISSUES
Demographics
Mucosa-Associated Lymphoid Tissue Lymphoma
High-Grade B-Cell Non-Hodgkin Lymphoma
Lymphomatoid Granulomatosis
Primary Pulmonary Plasmacytoma
Pulmonary Intravascular Lymphoma
DIAGNOSTIC CHECKLIST
Consider
Selected References
- Angirish B et al: Pulmonary manifestations of lymphoma: A pictorial essay. Lung India. 37(3):263-7, 2020
- Cozzi D et al: Primary pulmonary lymphoma: imaging findings in 30 cases. Radiol Med. 124(12):1262-9, 2019
- Deng W et al: Pulmonary MALT Lymphoma has variable features on CT. Sci Rep. 9(1):8657, 2019
- Yao D et al: Clinical and misdiagnosed analysis of primary pulmonary lymphoma: a retrospective study. BMC Cancer. 18(1):281, 2018
- Bligh MP et al: Spectrum of CT findings in thoracic extranodal non-Hodgkin lymphoma. Radiographics. 37(2):439-61, 2017
