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Pulmonary Non-Hodgkin Lymphoma
Carol C. Wu, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          • Diagnostic Checklist

            TERMINOLOGY

            • Abbreviations

              • Non-Hodgkin lymphoma (NHL)
            • Synonyms

              • Low-grade primary pulmonary B-cell lymphoma
              • Formerly called pseudolymphoma
            • Definitions

              • NHL accounts for 85-90% of all lymphomas
              • 40-45% of patients present with intrathoracic disease
              • NHL can involve lungs in 3 ways
                • Hematogenous dissemination of NHL
                • Contiguous invasion from hilar or mediastinal lymph nodes
                • Primary pulmonary NHL
                  • 0.4% of all lymphomas
                  • Clonal lymphoid proliferation affecting 1 or both lungs in patient with no detectable extrapulmonary involvement at diagnosis or during subsequent 3 months

            IMAGING

            • General Features

              • Radiographic Findings

                • CT Findings

                  • Imaging Recommendations

                    • Nuclear Medicine Findings

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Staging, Grading, & Classification

                            • Microscopic Features

                              CLINICAL ISSUES

                              • Low-Grade B-Cell NHL

                                • High-Grade B-Cell NHL

                                  • Primary Pulmonary Plasmacytoma

                                    • Pulmonary Intravascular Lymphoma

                                      • Lymphomatoid Granulomatosis

                                        • Peripheral T-Cell Lymphoma

                                          DIAGNOSTIC CHECKLIST

                                          • Consider

                                            Selected References

                                            1. Carter BW et al: Multimodality imaging of cardiothoracic lymphoma. Eur J Radiol. 83(8):1470-82, 2014
                                            2. William J et al: Lymphoproliferative neoplasms of the lung: a review. Arch Pathol Lab Med. 137(3):382-91, 2013
                                            3. Hare SS et al: The radiological spectrum of pulmonary lymphoproliferative disease. Br J Radiol. 85(1015):848-64, 2012
                                            4. Chung JH et al: Lymphomatoid granulomatosis: CT and FDG-PET findings. Korean J Radiol. 12(6):671-8, 2011
                                            5. Niida T et al: Pulmonary intravascular lymphoma diagnosed by 18-fluorodeoxyglucose positron emission tomography-guided transbronchial lung biopsy in a man with long-term survival: a case report. J Med Case Reports. 5(1):295, 2011
                                            6. Katzenstein AL et al: Lymphomatoid granulomatosis: insights gained over 4 decades. Am J Surg Pathol. 34(12):e35-48, 2010
                                            7. Chua SC et al: Imaging features of primary extranodal lymphomas. Clin Radiol. 64(6):574-88, 2009
                                            8. Bae YA et al: Cross-sectional evaluation of thoracic lymphoma. Radiol Clin North Am. 46(2):253-64, viii, 2008
                                            9. Solomonov A et al: Non-Hodgkin's lymphoma presenting as an endobronchial tumor: report of eight cases and literature review. Am J Hematol. 83(5):416-9, 2008
                                            10. Rademaker J: Hodgkin's and non-Hodgkin's lymphomas. Radiol Clin North Am. 45(1):69-83, 2007
                                            11. Ansell SM et al: Non-Hodgkin lymphoma: diagnosis and treatment. Mayo Clin Proc. 80(8):1087-97, 2005
                                            12. Lu P: Staging and classification of lymphoma. Semin Nucl Med. 35(3):160-4, 2005
                                            13. Cadranel J et al: Primary pulmonary lymphoma. Eur Respir J. 20(3):750-62, 2002
                                            Related Anatomy
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                                            Related Differential Diagnoses
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                                            References
                                            Tables

                                            Tables

                                            KEY FACTS

                                            • Terminology

                                              • Imaging

                                                • Top Differential Diagnoses

                                                  • Clinical Issues

                                                    • Diagnostic Checklist

                                                      TERMINOLOGY

                                                      • Abbreviations

                                                        • Non-Hodgkin lymphoma (NHL)
                                                      • Synonyms

                                                        • Low-grade primary pulmonary B-cell lymphoma
                                                        • Formerly called pseudolymphoma
                                                      • Definitions

                                                        • NHL accounts for 85-90% of all lymphomas
                                                        • 40-45% of patients present with intrathoracic disease
                                                        • NHL can involve lungs in 3 ways
                                                          • Hematogenous dissemination of NHL
                                                          • Contiguous invasion from hilar or mediastinal lymph nodes
                                                          • Primary pulmonary NHL
                                                            • 0.4% of all lymphomas
                                                            • Clonal lymphoid proliferation affecting 1 or both lungs in patient with no detectable extrapulmonary involvement at diagnosis or during subsequent 3 months

                                                      IMAGING

                                                      • General Features

                                                        • Radiographic Findings

                                                          • CT Findings

                                                            • Imaging Recommendations

                                                              • Nuclear Medicine Findings

                                                                DIFFERENTIAL DIAGNOSIS

                                                                  PATHOLOGY

                                                                  • General Features

                                                                    • Staging, Grading, & Classification

                                                                      • Microscopic Features

                                                                        CLINICAL ISSUES

                                                                        • Low-Grade B-Cell NHL

                                                                          • High-Grade B-Cell NHL

                                                                            • Primary Pulmonary Plasmacytoma

                                                                              • Pulmonary Intravascular Lymphoma

                                                                                • Lymphomatoid Granulomatosis

                                                                                  • Peripheral T-Cell Lymphoma

                                                                                    DIAGNOSTIC CHECKLIST

                                                                                    • Consider

                                                                                      Selected References

                                                                                      1. Carter BW et al: Multimodality imaging of cardiothoracic lymphoma. Eur J Radiol. 83(8):1470-82, 2014
                                                                                      2. William J et al: Lymphoproliferative neoplasms of the lung: a review. Arch Pathol Lab Med. 137(3):382-91, 2013
                                                                                      3. Hare SS et al: The radiological spectrum of pulmonary lymphoproliferative disease. Br J Radiol. 85(1015):848-64, 2012
                                                                                      4. Chung JH et al: Lymphomatoid granulomatosis: CT and FDG-PET findings. Korean J Radiol. 12(6):671-8, 2011
                                                                                      5. Niida T et al: Pulmonary intravascular lymphoma diagnosed by 18-fluorodeoxyglucose positron emission tomography-guided transbronchial lung biopsy in a man with long-term survival: a case report. J Med Case Reports. 5(1):295, 2011
                                                                                      6. Katzenstein AL et al: Lymphomatoid granulomatosis: insights gained over 4 decades. Am J Surg Pathol. 34(12):e35-48, 2010
                                                                                      7. Chua SC et al: Imaging features of primary extranodal lymphomas. Clin Radiol. 64(6):574-88, 2009
                                                                                      8. Bae YA et al: Cross-sectional evaluation of thoracic lymphoma. Radiol Clin North Am. 46(2):253-64, viii, 2008
                                                                                      9. Solomonov A et al: Non-Hodgkin's lymphoma presenting as an endobronchial tumor: report of eight cases and literature review. Am J Hematol. 83(5):416-9, 2008
                                                                                      10. Rademaker J: Hodgkin's and non-Hodgkin's lymphomas. Radiol Clin North Am. 45(1):69-83, 2007
                                                                                      11. Ansell SM et al: Non-Hodgkin lymphoma: diagnosis and treatment. Mayo Clin Proc. 80(8):1087-97, 2005
                                                                                      12. Lu P: Staging and classification of lymphoma. Semin Nucl Med. 35(3):160-4, 2005
                                                                                      13. Cadranel J et al: Primary pulmonary lymphoma. Eur Respir J. 20(3):750-62, 2002