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Pulmonary Sequestration
Brett W. Carter, MD; Gerald F. Abbott, MD, FACR
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          TERMINOLOGY

          • Definitions

            • From Latin "sequestrare" (to be separated)
            • Pulmonary sequestration
              • No normal communication with tracheobronchial tree
              • Systemic blood supply
            • Intralobar sequestration (ILS): ~ 75%
              • Shares visceral pleura of affected lobe
            • Extralobar sequestration (ELS): ~ 25%
              • Supernumerary lung tissue covered by pleura, separate from adjacent lung
            • Bronchopulmonary foregut malformation
              • Pulmonary sequestration (ELS or ILS) with foregut communication (esophagus, stomach) (rare)

          IMAGING

          • General Features

            • Radiographic Findings

              • CT Findings

                • MR Findings

                  • Angiographic Findings

                    • Imaging Recommendations

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Gross Pathologic & Surgical Features

                            • Microscopic Features

                              CLINICAL ISSUES

                              • Presentation

                                • Demographics

                                  • Natural History & Prognosis

                                    • Treatment

                                      Selected References

                                      1. Wei Y et al: Pulmonary sequestration: a retrospective analysis of 2625 cases in China. Eur J Cardiothorac Surg. 40(1):e39-42, 2011
                                      2. Biyyam DR et al: Congenital lung abnormalities: embryologic features, prenatal diagnosis, and postnatal radiologic-pathologic correlation. Radiographics. 30(6):1721-38, 2010
                                      3. Lee EY et al: Multidetector CT evaluation of congenital lung anomalies. Radiology. 247(3):632-48, 2008
                                      4. Newman B: Congenital bronchopulmonary foregut malformations: concepts and controversies. Pediatr Radiol. 36(8):773-91, 2006
                                      5. Corbett HJ et al: Pulmonary sequestration. Paediatr Respir Rev. 5(1):59-68, 2004
                                      6. Zylak CJ et al: Developmental lung anomalies in the adult: radiologic-pathologic correlation. Radiographics. 22 Spec No:S25-43, 2002
                                      7. Bratu I et al: The multiple facets of pulmonary sequestration. J Pediatr Surg. 36(5):784-90, 2001
                                      8. Do KH et al: Systemic arterial supply to the lungs in adults: spiral CT findings. Radiographics. 21(2):387-402, 2001
                                      9. Saygi A: Intralobar pulmonary sequestration. Chest. 119(3):990-2, 2001
                                      10. Frazier AA et al: Intralobar sequestration: radiologic-pathologic correlation. Radiographics. 17(3):725-45, 1997
                                      Related Anatomy
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                                      Related Differential Diagnoses
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                                      References
                                      Tables

                                      Tables

                                      KEY FACTS

                                      • Terminology

                                        • Imaging

                                          • Top Differential Diagnoses

                                            • Clinical Issues

                                              TERMINOLOGY

                                              • Definitions

                                                • From Latin "sequestrare" (to be separated)
                                                • Pulmonary sequestration
                                                  • No normal communication with tracheobronchial tree
                                                  • Systemic blood supply
                                                • Intralobar sequestration (ILS): ~ 75%
                                                  • Shares visceral pleura of affected lobe
                                                • Extralobar sequestration (ELS): ~ 25%
                                                  • Supernumerary lung tissue covered by pleura, separate from adjacent lung
                                                • Bronchopulmonary foregut malformation
                                                  • Pulmonary sequestration (ELS or ILS) with foregut communication (esophagus, stomach) (rare)

                                              IMAGING

                                              • General Features

                                                • Radiographic Findings

                                                  • CT Findings

                                                    • MR Findings

                                                      • Angiographic Findings

                                                        • Imaging Recommendations

                                                          DIFFERENTIAL DIAGNOSIS

                                                            PATHOLOGY

                                                            • General Features

                                                              • Gross Pathologic & Surgical Features

                                                                • Microscopic Features

                                                                  CLINICAL ISSUES

                                                                  • Presentation

                                                                    • Demographics

                                                                      • Natural History & Prognosis

                                                                        • Treatment

                                                                          Selected References

                                                                          1. Wei Y et al: Pulmonary sequestration: a retrospective analysis of 2625 cases in China. Eur J Cardiothorac Surg. 40(1):e39-42, 2011
                                                                          2. Biyyam DR et al: Congenital lung abnormalities: embryologic features, prenatal diagnosis, and postnatal radiologic-pathologic correlation. Radiographics. 30(6):1721-38, 2010
                                                                          3. Lee EY et al: Multidetector CT evaluation of congenital lung anomalies. Radiology. 247(3):632-48, 2008
                                                                          4. Newman B: Congenital bronchopulmonary foregut malformations: concepts and controversies. Pediatr Radiol. 36(8):773-91, 2006
                                                                          5. Corbett HJ et al: Pulmonary sequestration. Paediatr Respir Rev. 5(1):59-68, 2004
                                                                          6. Zylak CJ et al: Developmental lung anomalies in the adult: radiologic-pathologic correlation. Radiographics. 22 Spec No:S25-43, 2002
                                                                          7. Bratu I et al: The multiple facets of pulmonary sequestration. J Pediatr Surg. 36(5):784-90, 2001
                                                                          8. Do KH et al: Systemic arterial supply to the lungs in adults: spiral CT findings. Radiographics. 21(2):387-402, 2001
                                                                          9. Saygi A: Intralobar pulmonary sequestration. Chest. 119(3):990-2, 2001
                                                                          10. Frazier AA et al: Intralobar sequestration: radiologic-pathologic correlation. Radiographics. 17(3):725-45, 1997