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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Abbreviations
- Pyriform sinus (PS) squamous cell carcinoma (SCCa)
Synonyms
- Piriform sinus SCCa, pyriform fossa SCCa
Definitions
- Mucosal malignancy of hypopharyngeal subsite
- 2/3 of all hypopharyngeal SCCa arise in PS
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Reporting Tips
Selected References
- Cho SJ et al: Comparison of diagnostic performance between CT and MRI for detection of cartilage invasion for primary tumor staging in patients with laryngo-hypopharyngeal cancer: a systematic review and meta-analysis. Eur Radiol. 30(7):3803-12, 2020
- Lin Z et al: Dynamic prediction of cancer-specific survival for primary hypopharyngeal squamous cell carcinoma. Int J Clin Oncol. 25(7):1260-9, 2020
- Piazza C et al: Clinical and radiological evaluation of hypopharyngeal carcinoma. Adv Otorhinolaryngol. 83:35-46, 2019
- Tanzler ED et al: Challenging the need for random directed biopsies of the nasopharynx, pyriform sinus, and contralateral tonsil in the workup of unknown primary squamous cell carcinoma of the head and neck. Head Neck. 38(4):578-81, 2016
- Chung EJ et al: Pattern of cervical lymph node metastasis in medial wall pyriform sinus carcinoma. Laryngoscope. 124(4):882-7, 2014
- Yu Y et al: Neoadjuvant treatment combined with planned surgery in laryngeal function preservation for locally advanced pyriform sinus carcinoma. J Craniofac Surg. 25(6):1975-9, 2014
- Chen AY et al: Pitfalls in the staging squamous cell carcinoma of the hypopharynx. Neuroimaging Clin N Am. 23(1):67-79, 2013
- Blanchard P et al: Definitive radiotherapy for squamous cell carcinoma of the pyriform sinus. Radiother Oncol. 105(2):232-7, 2012
- Bonner JA et al: Radiotherapy plus cetuximab for locoregionally advanced head and neck cancer: 5-year survival data from a phase 3 randomised trial, and relation between cetuximab-induced rash and survival. Lancet Oncol. 2010 Jan;11(1):21-8. Epub 2009 Nov 10. Erratum in: Lancet Oncol. 11(1):14, 2010
- Chu PY et al: Different patterns of second primary malignancy in patients with squamous cell carcinoma of larynx and hypopharynx. Am J Otolaryngol. 31(3):168-74, 2010
- Datema FR et al: Impact of comorbidity on short-term mortality and overall survival of head and neck cancer patients. Head Neck. 32(6):728-36, 2010
- Inohara H et al: Impact of FDG-PET on prediction of clinical outcome after concurrent chemoradiotherapy in hypopharyngeal carcinoma. Mol Imaging Biol. 12(1):89-97, 2010
- Joo YH et al: The impact of paratracheal lymph node metastasis in squamous cell carcinoma of the hypopharynx. Eur Arch Otorhinolaryngol. 267(6):945-50, 2010
- Kadota H et al: Comparison of salvage and planned pharyngolaryngectomy with jejunal transfer for hypopharyngeal carcinoma after chemoradiotherapy. Laryngoscope. 120(6):1103-8, 2010
- Karatzanis AD et al: T1 and T2 hypopharyngeal cancer treatment with laser microsurgery. J Surg Oncol. 102(1):27-33, 2010
- Leong SC et al: Early outcomes after transoral CO2 laser resection of laryngeal and hypopharyngeal squamous cell carcinoma: one centre's experience. J Laryngol Otol. 124(2):185-93, 2010
- Liu WS et al: Long-term results of intensity-modulated radiotherapy concomitant with chemotherapy for hypopharyngeal carcinoma aimed at laryngeal preservation. BMC Cancer. 10:102, 2010
- Park YM et al: Feasiblity of transoral robotic hypopharyngectomy for early-stage hypopharyngeal carcinoma. Oral Oncol. 46(8):597-602, 2010
- Tandon S et al: A systematic review of p53 as a prognostic factor of survival in squamous cell carcinoma of the four main anatomical subsites of the head and neck. Cancer Epidemiol Biomarkers Prev. 19(2):574-87, 2010
- Curado MP et al: Recent changes in the epidemiology of head and neck cancer. Curr Opin Oncol. 21(3):194-200, 2009
- Kogashiwa Y et al: Concurrent chemoradiotherapy for organ function preservation in advanced patients with hypopharyngeal and laryngeal cancer. Oncol Rep. 22(5):1163-7, 2009
- Mendenhall WM: Outcomes after surgery or definitive radiotherapy for hypopharyngeal cancer. Cancer. 115(24):5620-2, 2009
- Papacharalampous GX et al: Supracricoid hemilaryngopharyngectomy for selected pyriform sinus carcinoma patients--a retrospective chart review. World J Surg Oncol. 7:65, 2009
- Varghese BT et al: Treatment outcome in patients undergoing surgery for carcinoma larynx and hypopharynx: a follow-up study. Acta Otolaryngol. 129(12):1480-5, 2009
- Verduijn GM et al: Magnetic resonance imaging protocol optimization for delineation of gross tumor volume in hypopharyngeal and laryngeal tumors. Int J Radiat Oncol Biol Phys. 74(2):630-6, 2009
- Becker M et al: Imaging of the larynx and hypopharynx. Eur J Radiol. 66(3):460-79, 2008
- Becker M et al: Neoplastic invasion of laryngeal cartilage: reassessment of criteria for diagnosis at MR imaging. Radiology. 249(2):551-9, 2008
- Wycliffe ND et al: Hypopharyngeal cancer. Top Magn Reson Imaging. 18(4):243-58, 2007
- Hermans R: Staging of laryngeal and hypopharyngeal cancer: value of imaging studies. Eur Radiol. 16(11):2386-400, 2006
- Gleich LL et al: Recurrent advanced (T3 or T4) head and neck squamous cell carcinoma: is salvage possible? Arch Otolaryngol Head Neck Surg. 130(1):35-8, 2004
- Gourin CG et al: Carcinoma of the hypopharynx. Surg Oncol Clin N Am. 13(1):81-98, 2004
- Hanna E et al: Intensive chemoradiotherapy as a primary treatment for organ preservation in patients with advanced cancer of the head and neck: efficacy, toxic effects, and limitations. Arch Otolaryngol Head Neck Surg. 130(7):861-7, 2004
- Kutter J et al: Combined modality treatment with full-dose chemotherapy and concomitant boost radiotherapy for advanced head and neck carcinoma. Eur Arch Otorhinolaryngol. 261(6):400-6, 2004
- Agra IM et al: Postoperative complications after en bloc salvage surgery for head and neck cancer. Arch Otolaryngol Head Neck Surg. 129(12):1317-21, 2003
- Lore JM Jr et al: Carcinoma of the head and neck: a 5- to 20-year experience with preoperative chemotherapy, uncompromised surgery, and selective radiotherapy. Ann Surg Oncol. 10(6):645-53, 2003
- Schmalfuss IM: Imaging of the hypopharynx and cervical esophagus. Magn Reson Imaging Clin N Am. 10(3):495-509, vi, 2002
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Abbreviations
- Pyriform sinus (PS) squamous cell carcinoma (SCCa)
Synonyms
- Piriform sinus SCCa, pyriform fossa SCCa
Definitions
- Mucosal malignancy of hypopharyngeal subsite
- 2/3 of all hypopharyngeal SCCa arise in PS
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Reporting Tips
Selected References
- Cho SJ et al: Comparison of diagnostic performance between CT and MRI for detection of cartilage invasion for primary tumor staging in patients with laryngo-hypopharyngeal cancer: a systematic review and meta-analysis. Eur Radiol. 30(7):3803-12, 2020
- Lin Z et al: Dynamic prediction of cancer-specific survival for primary hypopharyngeal squamous cell carcinoma. Int J Clin Oncol. 25(7):1260-9, 2020
- Piazza C et al: Clinical and radiological evaluation of hypopharyngeal carcinoma. Adv Otorhinolaryngol. 83:35-46, 2019
- Tanzler ED et al: Challenging the need for random directed biopsies of the nasopharynx, pyriform sinus, and contralateral tonsil in the workup of unknown primary squamous cell carcinoma of the head and neck. Head Neck. 38(4):578-81, 2016
- Chung EJ et al: Pattern of cervical lymph node metastasis in medial wall pyriform sinus carcinoma. Laryngoscope. 124(4):882-7, 2014
- Yu Y et al: Neoadjuvant treatment combined with planned surgery in laryngeal function preservation for locally advanced pyriform sinus carcinoma. J Craniofac Surg. 25(6):1975-9, 2014
- Chen AY et al: Pitfalls in the staging squamous cell carcinoma of the hypopharynx. Neuroimaging Clin N Am. 23(1):67-79, 2013
- Blanchard P et al: Definitive radiotherapy for squamous cell carcinoma of the pyriform sinus. Radiother Oncol. 105(2):232-7, 2012
- Bonner JA et al: Radiotherapy plus cetuximab for locoregionally advanced head and neck cancer: 5-year survival data from a phase 3 randomised trial, and relation between cetuximab-induced rash and survival. Lancet Oncol. 2010 Jan;11(1):21-8. Epub 2009 Nov 10. Erratum in: Lancet Oncol. 11(1):14, 2010
- Chu PY et al: Different patterns of second primary malignancy in patients with squamous cell carcinoma of larynx and hypopharynx. Am J Otolaryngol. 31(3):168-74, 2010
- Datema FR et al: Impact of comorbidity on short-term mortality and overall survival of head and neck cancer patients. Head Neck. 32(6):728-36, 2010
- Inohara H et al: Impact of FDG-PET on prediction of clinical outcome after concurrent chemoradiotherapy in hypopharyngeal carcinoma. Mol Imaging Biol. 12(1):89-97, 2010
- Joo YH et al: The impact of paratracheal lymph node metastasis in squamous cell carcinoma of the hypopharynx. Eur Arch Otorhinolaryngol. 267(6):945-50, 2010
- Kadota H et al: Comparison of salvage and planned pharyngolaryngectomy with jejunal transfer for hypopharyngeal carcinoma after chemoradiotherapy. Laryngoscope. 120(6):1103-8, 2010
- Karatzanis AD et al: T1 and T2 hypopharyngeal cancer treatment with laser microsurgery. J Surg Oncol. 102(1):27-33, 2010
- Leong SC et al: Early outcomes after transoral CO2 laser resection of laryngeal and hypopharyngeal squamous cell carcinoma: one centre's experience. J Laryngol Otol. 124(2):185-93, 2010
- Liu WS et al: Long-term results of intensity-modulated radiotherapy concomitant with chemotherapy for hypopharyngeal carcinoma aimed at laryngeal preservation. BMC Cancer. 10:102, 2010
- Park YM et al: Feasiblity of transoral robotic hypopharyngectomy for early-stage hypopharyngeal carcinoma. Oral Oncol. 46(8):597-602, 2010
- Tandon S et al: A systematic review of p53 as a prognostic factor of survival in squamous cell carcinoma of the four main anatomical subsites of the head and neck. Cancer Epidemiol Biomarkers Prev. 19(2):574-87, 2010
- Curado MP et al: Recent changes in the epidemiology of head and neck cancer. Curr Opin Oncol. 21(3):194-200, 2009
- Kogashiwa Y et al: Concurrent chemoradiotherapy for organ function preservation in advanced patients with hypopharyngeal and laryngeal cancer. Oncol Rep. 22(5):1163-7, 2009
- Mendenhall WM: Outcomes after surgery or definitive radiotherapy for hypopharyngeal cancer. Cancer. 115(24):5620-2, 2009
- Papacharalampous GX et al: Supracricoid hemilaryngopharyngectomy for selected pyriform sinus carcinoma patients--a retrospective chart review. World J Surg Oncol. 7:65, 2009
- Varghese BT et al: Treatment outcome in patients undergoing surgery for carcinoma larynx and hypopharynx: a follow-up study. Acta Otolaryngol. 129(12):1480-5, 2009
- Verduijn GM et al: Magnetic resonance imaging protocol optimization for delineation of gross tumor volume in hypopharyngeal and laryngeal tumors. Int J Radiat Oncol Biol Phys. 74(2):630-6, 2009
- Becker M et al: Imaging of the larynx and hypopharynx. Eur J Radiol. 66(3):460-79, 2008
- Becker M et al: Neoplastic invasion of laryngeal cartilage: reassessment of criteria for diagnosis at MR imaging. Radiology. 249(2):551-9, 2008
- Wycliffe ND et al: Hypopharyngeal cancer. Top Magn Reson Imaging. 18(4):243-58, 2007
- Hermans R: Staging of laryngeal and hypopharyngeal cancer: value of imaging studies. Eur Radiol. 16(11):2386-400, 2006
- Gleich LL et al: Recurrent advanced (T3 or T4) head and neck squamous cell carcinoma: is salvage possible? Arch Otolaryngol Head Neck Surg. 130(1):35-8, 2004
- Gourin CG et al: Carcinoma of the hypopharynx. Surg Oncol Clin N Am. 13(1):81-98, 2004
- Hanna E et al: Intensive chemoradiotherapy as a primary treatment for organ preservation in patients with advanced cancer of the head and neck: efficacy, toxic effects, and limitations. Arch Otolaryngol Head Neck Surg. 130(7):861-7, 2004
- Kutter J et al: Combined modality treatment with full-dose chemotherapy and concomitant boost radiotherapy for advanced head and neck carcinoma. Eur Arch Otorhinolaryngol. 261(6):400-6, 2004
- Agra IM et al: Postoperative complications after en bloc salvage surgery for head and neck cancer. Arch Otolaryngol Head Neck Surg. 129(12):1317-21, 2003
- Lore JM Jr et al: Carcinoma of the head and neck: a 5- to 20-year experience with preoperative chemotherapy, uncompromised surgery, and selective radiotherapy. Ann Surg Oncol. 10(6):645-53, 2003
- Schmalfuss IM: Imaging of the hypopharynx and cervical esophagus. Magn Reson Imaging Clin N Am. 10(3):495-509, vi, 2002
