link
Bookmarks
Pyriform Sinus Squamous Cell Carcinoma
Surjith Vattoth, MD, FRCR
To access 4,300 diagnoses written by the world's leading experts in radiology, please log in or subscribe.Subscribe
1
8
2
5

KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Abbreviations

              • Pyriform sinus (PS) squamous cell carcinoma (SCCa)
            • Synonyms

              • Piriform sinus SCCa, pyriform fossa SCCa
            • Definitions

              • Mucosal malignancy of hypopharyngeal subsite
              • 2/3 of all hypopharyngeal SCCa arise in PS

            IMAGING

            • General Features

              • Radiographic Findings

                • CT Findings

                  • MR Findings

                    • Nuclear Medicine Findings

                      • Imaging Recommendations

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Staging, Grading, & Classification

                              • Gross Pathologic & Surgical Features

                                • Microscopic Features

                                  CLINICAL ISSUES

                                  • Presentation

                                    • Demographics

                                      • Natural History & Prognosis

                                        • Treatment

                                          DIAGNOSTIC CHECKLIST

                                          • Consider

                                            • Image Interpretation Pearls

                                              • Reporting Tips

                                                Selected References

                                                1. Cho SJ et al: Comparison of diagnostic performance between CT and MRI for detection of cartilage invasion for primary tumor staging in patients with laryngo-hypopharyngeal cancer: a systematic review and meta-analysis. Eur Radiol. 30(7):3803-12, 2020
                                                2. Lin Z et al: Dynamic prediction of cancer-specific survival for primary hypopharyngeal squamous cell carcinoma. Int J Clin Oncol. 25(7):1260-9, 2020
                                                3. Piazza C et al: Clinical and radiological evaluation of hypopharyngeal carcinoma. Adv Otorhinolaryngol. 83:35-46, 2019
                                                4. Tanzler ED et al: Challenging the need for random directed biopsies of the nasopharynx, pyriform sinus, and contralateral tonsil in the workup of unknown primary squamous cell carcinoma of the head and neck. Head Neck. 38(4):578-81, 2016
                                                5. Chung EJ et al: Pattern of cervical lymph node metastasis in medial wall pyriform sinus carcinoma. Laryngoscope. 124(4):882-7, 2014
                                                6. Yu Y et al: Neoadjuvant treatment combined with planned surgery in laryngeal function preservation for locally advanced pyriform sinus carcinoma. J Craniofac Surg. 25(6):1975-9, 2014
                                                7. Chen AY et al: Pitfalls in the staging squamous cell carcinoma of the hypopharynx. Neuroimaging Clin N Am. 23(1):67-79, 2013
                                                8. Blanchard P et al: Definitive radiotherapy for squamous cell carcinoma of the pyriform sinus. Radiother Oncol. 105(2):232-7, 2012
                                                9. Bonner JA et al: Radiotherapy plus cetuximab for locoregionally advanced head and neck cancer: 5-year survival data from a phase 3 randomised trial, and relation between cetuximab-induced rash and survival. Lancet Oncol. 2010 Jan;11(1):21-8. Epub 2009 Nov 10. Erratum in: Lancet Oncol. 11(1):14, 2010
                                                10. Chu PY et al: Different patterns of second primary malignancy in patients with squamous cell carcinoma of larynx and hypopharynx. Am J Otolaryngol. 31(3):168-74, 2010
                                                11. Datema FR et al: Impact of comorbidity on short-term mortality and overall survival of head and neck cancer patients. Head Neck. 32(6):728-36, 2010
                                                12. Inohara H et al: Impact of FDG-PET on prediction of clinical outcome after concurrent chemoradiotherapy in hypopharyngeal carcinoma. Mol Imaging Biol. 12(1):89-97, 2010
                                                13. Joo YH et al: The impact of paratracheal lymph node metastasis in squamous cell carcinoma of the hypopharynx. Eur Arch Otorhinolaryngol. 267(6):945-50, 2010
                                                14. Kadota H et al: Comparison of salvage and planned pharyngolaryngectomy with jejunal transfer for hypopharyngeal carcinoma after chemoradiotherapy. Laryngoscope. 120(6):1103-8, 2010
                                                15. Karatzanis AD et al: T1 and T2 hypopharyngeal cancer treatment with laser microsurgery. J Surg Oncol. 102(1):27-33, 2010
                                                16. Leong SC et al: Early outcomes after transoral CO2 laser resection of laryngeal and hypopharyngeal squamous cell carcinoma: one centre's experience. J Laryngol Otol. 124(2):185-93, 2010
                                                17. Liu WS et al: Long-term results of intensity-modulated radiotherapy concomitant with chemotherapy for hypopharyngeal carcinoma aimed at laryngeal preservation. BMC Cancer. 10:102, 2010
                                                18. Park YM et al: Feasiblity of transoral robotic hypopharyngectomy for early-stage hypopharyngeal carcinoma. Oral Oncol. 46(8):597-602, 2010
                                                19. Tandon S et al: A systematic review of p53 as a prognostic factor of survival in squamous cell carcinoma of the four main anatomical subsites of the head and neck. Cancer Epidemiol Biomarkers Prev. 19(2):574-87, 2010
                                                20. Curado MP et al: Recent changes in the epidemiology of head and neck cancer. Curr Opin Oncol. 21(3):194-200, 2009
                                                21. Kogashiwa Y et al: Concurrent chemoradiotherapy for organ function preservation in advanced patients with hypopharyngeal and laryngeal cancer. Oncol Rep. 22(5):1163-7, 2009
                                                22. Mendenhall WM: Outcomes after surgery or definitive radiotherapy for hypopharyngeal cancer. Cancer. 115(24):5620-2, 2009
                                                23. Papacharalampous GX et al: Supracricoid hemilaryngopharyngectomy for selected pyriform sinus carcinoma patients--a retrospective chart review. World J Surg Oncol. 7:65, 2009
                                                24. Varghese BT et al: Treatment outcome in patients undergoing surgery for carcinoma larynx and hypopharynx: a follow-up study. Acta Otolaryngol. 129(12):1480-5, 2009
                                                25. Verduijn GM et al: Magnetic resonance imaging protocol optimization for delineation of gross tumor volume in hypopharyngeal and laryngeal tumors. Int J Radiat Oncol Biol Phys. 74(2):630-6, 2009
                                                26. Becker M et al: Imaging of the larynx and hypopharynx. Eur J Radiol. 66(3):460-79, 2008
                                                27. Becker M et al: Neoplastic invasion of laryngeal cartilage: reassessment of criteria for diagnosis at MR imaging. Radiology. 249(2):551-9, 2008
                                                28. Wycliffe ND et al: Hypopharyngeal cancer. Top Magn Reson Imaging. 18(4):243-58, 2007
                                                29. Hermans R: Staging of laryngeal and hypopharyngeal cancer: value of imaging studies. Eur Radiol. 16(11):2386-400, 2006
                                                30. Gleich LL et al: Recurrent advanced (T3 or T4) head and neck squamous cell carcinoma: is salvage possible? Arch Otolaryngol Head Neck Surg. 130(1):35-8, 2004
                                                31. Gourin CG et al: Carcinoma of the hypopharynx. Surg Oncol Clin N Am. 13(1):81-98, 2004
                                                32. Hanna E et al: Intensive chemoradiotherapy as a primary treatment for organ preservation in patients with advanced cancer of the head and neck: efficacy, toxic effects, and limitations. Arch Otolaryngol Head Neck Surg. 130(7):861-7, 2004
                                                33. Kutter J et al: Combined modality treatment with full-dose chemotherapy and concomitant boost radiotherapy for advanced head and neck carcinoma. Eur Arch Otorhinolaryngol. 261(6):400-6, 2004
                                                34. Agra IM et al: Postoperative complications after en bloc salvage surgery for head and neck cancer. Arch Otolaryngol Head Neck Surg. 129(12):1317-21, 2003
                                                35. Lore JM Jr et al: Carcinoma of the head and neck: a 5- to 20-year experience with preoperative chemotherapy, uncompromised surgery, and selective radiotherapy. Ann Surg Oncol. 10(6):645-53, 2003
                                                36. Schmalfuss IM: Imaging of the hypopharynx and cervical esophagus. Magn Reson Imaging Clin N Am. 10(3):495-509, vi, 2002
                                                Related Anatomy
                                                Loading...
                                                Related Differential Diagnoses
                                                Loading...
                                                References
                                                Tables

                                                Tables

                                                KEY FACTS

                                                • Terminology

                                                  • Imaging

                                                    • Top Differential Diagnoses

                                                      • Pathology

                                                        • Clinical Issues

                                                          TERMINOLOGY

                                                          • Abbreviations

                                                            • Pyriform sinus (PS) squamous cell carcinoma (SCCa)
                                                          • Synonyms

                                                            • Piriform sinus SCCa, pyriform fossa SCCa
                                                          • Definitions

                                                            • Mucosal malignancy of hypopharyngeal subsite
                                                            • 2/3 of all hypopharyngeal SCCa arise in PS

                                                          IMAGING

                                                          • General Features

                                                            • Radiographic Findings

                                                              • CT Findings

                                                                • MR Findings

                                                                  • Nuclear Medicine Findings

                                                                    • Imaging Recommendations

                                                                      DIFFERENTIAL DIAGNOSIS

                                                                        PATHOLOGY

                                                                        • General Features

                                                                          • Staging, Grading, & Classification

                                                                            • Gross Pathologic & Surgical Features

                                                                              • Microscopic Features

                                                                                CLINICAL ISSUES

                                                                                • Presentation

                                                                                  • Demographics

                                                                                    • Natural History & Prognosis

                                                                                      • Treatment

                                                                                        DIAGNOSTIC CHECKLIST

                                                                                        • Consider

                                                                                          • Image Interpretation Pearls

                                                                                            • Reporting Tips

                                                                                              Selected References

                                                                                              1. Cho SJ et al: Comparison of diagnostic performance between CT and MRI for detection of cartilage invasion for primary tumor staging in patients with laryngo-hypopharyngeal cancer: a systematic review and meta-analysis. Eur Radiol. 30(7):3803-12, 2020
                                                                                              2. Lin Z et al: Dynamic prediction of cancer-specific survival for primary hypopharyngeal squamous cell carcinoma. Int J Clin Oncol. 25(7):1260-9, 2020
                                                                                              3. Piazza C et al: Clinical and radiological evaluation of hypopharyngeal carcinoma. Adv Otorhinolaryngol. 83:35-46, 2019
                                                                                              4. Tanzler ED et al: Challenging the need for random directed biopsies of the nasopharynx, pyriform sinus, and contralateral tonsil in the workup of unknown primary squamous cell carcinoma of the head and neck. Head Neck. 38(4):578-81, 2016
                                                                                              5. Chung EJ et al: Pattern of cervical lymph node metastasis in medial wall pyriform sinus carcinoma. Laryngoscope. 124(4):882-7, 2014
                                                                                              6. Yu Y et al: Neoadjuvant treatment combined with planned surgery in laryngeal function preservation for locally advanced pyriform sinus carcinoma. J Craniofac Surg. 25(6):1975-9, 2014
                                                                                              7. Chen AY et al: Pitfalls in the staging squamous cell carcinoma of the hypopharynx. Neuroimaging Clin N Am. 23(1):67-79, 2013
                                                                                              8. Blanchard P et al: Definitive radiotherapy for squamous cell carcinoma of the pyriform sinus. Radiother Oncol. 105(2):232-7, 2012
                                                                                              9. Bonner JA et al: Radiotherapy plus cetuximab for locoregionally advanced head and neck cancer: 5-year survival data from a phase 3 randomised trial, and relation between cetuximab-induced rash and survival. Lancet Oncol. 2010 Jan;11(1):21-8. Epub 2009 Nov 10. Erratum in: Lancet Oncol. 11(1):14, 2010
                                                                                              10. Chu PY et al: Different patterns of second primary malignancy in patients with squamous cell carcinoma of larynx and hypopharynx. Am J Otolaryngol. 31(3):168-74, 2010
                                                                                              11. Datema FR et al: Impact of comorbidity on short-term mortality and overall survival of head and neck cancer patients. Head Neck. 32(6):728-36, 2010
                                                                                              12. Inohara H et al: Impact of FDG-PET on prediction of clinical outcome after concurrent chemoradiotherapy in hypopharyngeal carcinoma. Mol Imaging Biol. 12(1):89-97, 2010
                                                                                              13. Joo YH et al: The impact of paratracheal lymph node metastasis in squamous cell carcinoma of the hypopharynx. Eur Arch Otorhinolaryngol. 267(6):945-50, 2010
                                                                                              14. Kadota H et al: Comparison of salvage and planned pharyngolaryngectomy with jejunal transfer for hypopharyngeal carcinoma after chemoradiotherapy. Laryngoscope. 120(6):1103-8, 2010
                                                                                              15. Karatzanis AD et al: T1 and T2 hypopharyngeal cancer treatment with laser microsurgery. J Surg Oncol. 102(1):27-33, 2010
                                                                                              16. Leong SC et al: Early outcomes after transoral CO2 laser resection of laryngeal and hypopharyngeal squamous cell carcinoma: one centre's experience. J Laryngol Otol. 124(2):185-93, 2010
                                                                                              17. Liu WS et al: Long-term results of intensity-modulated radiotherapy concomitant with chemotherapy for hypopharyngeal carcinoma aimed at laryngeal preservation. BMC Cancer. 10:102, 2010
                                                                                              18. Park YM et al: Feasiblity of transoral robotic hypopharyngectomy for early-stage hypopharyngeal carcinoma. Oral Oncol. 46(8):597-602, 2010
                                                                                              19. Tandon S et al: A systematic review of p53 as a prognostic factor of survival in squamous cell carcinoma of the four main anatomical subsites of the head and neck. Cancer Epidemiol Biomarkers Prev. 19(2):574-87, 2010
                                                                                              20. Curado MP et al: Recent changes in the epidemiology of head and neck cancer. Curr Opin Oncol. 21(3):194-200, 2009
                                                                                              21. Kogashiwa Y et al: Concurrent chemoradiotherapy for organ function preservation in advanced patients with hypopharyngeal and laryngeal cancer. Oncol Rep. 22(5):1163-7, 2009
                                                                                              22. Mendenhall WM: Outcomes after surgery or definitive radiotherapy for hypopharyngeal cancer. Cancer. 115(24):5620-2, 2009
                                                                                              23. Papacharalampous GX et al: Supracricoid hemilaryngopharyngectomy for selected pyriform sinus carcinoma patients--a retrospective chart review. World J Surg Oncol. 7:65, 2009
                                                                                              24. Varghese BT et al: Treatment outcome in patients undergoing surgery for carcinoma larynx and hypopharynx: a follow-up study. Acta Otolaryngol. 129(12):1480-5, 2009
                                                                                              25. Verduijn GM et al: Magnetic resonance imaging protocol optimization for delineation of gross tumor volume in hypopharyngeal and laryngeal tumors. Int J Radiat Oncol Biol Phys. 74(2):630-6, 2009
                                                                                              26. Becker M et al: Imaging of the larynx and hypopharynx. Eur J Radiol. 66(3):460-79, 2008
                                                                                              27. Becker M et al: Neoplastic invasion of laryngeal cartilage: reassessment of criteria for diagnosis at MR imaging. Radiology. 249(2):551-9, 2008
                                                                                              28. Wycliffe ND et al: Hypopharyngeal cancer. Top Magn Reson Imaging. 18(4):243-58, 2007
                                                                                              29. Hermans R: Staging of laryngeal and hypopharyngeal cancer: value of imaging studies. Eur Radiol. 16(11):2386-400, 2006
                                                                                              30. Gleich LL et al: Recurrent advanced (T3 or T4) head and neck squamous cell carcinoma: is salvage possible? Arch Otolaryngol Head Neck Surg. 130(1):35-8, 2004
                                                                                              31. Gourin CG et al: Carcinoma of the hypopharynx. Surg Oncol Clin N Am. 13(1):81-98, 2004
                                                                                              32. Hanna E et al: Intensive chemoradiotherapy as a primary treatment for organ preservation in patients with advanced cancer of the head and neck: efficacy, toxic effects, and limitations. Arch Otolaryngol Head Neck Surg. 130(7):861-7, 2004
                                                                                              33. Kutter J et al: Combined modality treatment with full-dose chemotherapy and concomitant boost radiotherapy for advanced head and neck carcinoma. Eur Arch Otorhinolaryngol. 261(6):400-6, 2004
                                                                                              34. Agra IM et al: Postoperative complications after en bloc salvage surgery for head and neck cancer. Arch Otolaryngol Head Neck Surg. 129(12):1317-21, 2003
                                                                                              35. Lore JM Jr et al: Carcinoma of the head and neck: a 5- to 20-year experience with preoperative chemotherapy, uncompromised surgery, and selective radiotherapy. Ann Surg Oncol. 10(6):645-53, 2003
                                                                                              36. Schmalfuss IM: Imaging of the hypopharynx and cervical esophagus. Magn Reson Imaging Clin N Am. 10(3):495-509, vi, 2002