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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Abbreviations
Radiation-induced liver disease (RILD)
Definitions
Syndrome characterized by development of anicteric ascites ~ 2 weeks to 4 months after hepatic irradiation
Form of venoocclusive disease due to fibrous obliteration of terminal hepatic venules → postsinusoidal obstruction
IMAGING
General Features
CT Findings
MR Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Selected References
De La Pinta Alonso C: Radiation-induced liver disease in the era of SBRT: a review. Expert Rev Gastroenterol Hepatol. 14(12):1195-201, 2020
Koay EJ et al: Radiation-induced liver disease and modern radiotherapy. Semin Radiat Oncol. 28(4):321-31, 2018
Takamatsu S et al: Pathology and images of radiation-induced hepatitis: a review article. Jpn J Radiol. 36(4):241-56, 2018
Munoz-Schuffenegger P et al: Radiation-induced liver toxicity. Semin Radiat Oncol. 27(4):350-7, 2017
Jung J et al: Radiation-induced liver disease after stereotactic body radiotherapy for small hepatocellular carcinoma: clinical and dose-volumetric parameters. Radiat Oncol. 8:249, 2013
Ng SC et al: Patient dosimetry for 90Y selective internal radiation treatment based on 90Y PET imaging. J Appl Clin Med Phys. 14(5):212-21, 2013
Tao C et al: Improved radiotherapy for primary and secondary liver cancer: stereotactic body radiation therapy. Anticancer Res. 32(2):649-55, 2012
Guha C et al: Hepatic radiation toxicity: avoidance and amelioration. Semin Radiat Oncol. 21(4):256-63, 2011
Nalesnik MA et al: Hepatobiliary effects of 90yttrium microsphere therapy for unresectable hepatocellular carcinoma. Hum Pathol. 40(1):125-34, 2009
Neff R et al: The toxicity of liver directed yttrium-90 microspheres in primary and metastatic liver tumors. Cancer Invest. 26(2):173-7, 2008
Szyszko T et al: Management and prevention of adverse effects related to treatment of liver tumours with 90Y microspheres. Nucl Med Commun. 28(1):21-4, 2007
Mori H et al: Radiation-induced liver injury showing low intensity on T2-weighted images noted in Budd-Chiari syndrome. Radiat Med. 20(2):69-76, 2002
Willemart S et al: Acute radiation-induced hepatic injury: evaluation by triphasic contrast enhanced helical CT. Br J Radiol. 73(869):544-6, 2000
Unger EC et al: CT and MR imaging of radiation hepatitis. J Comput Assist Tomogr. 11(2):264-8, 1987
Related Anatomy
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Related Differential Diagnoses
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Abbreviations
Radiation-induced liver disease (RILD)
Definitions
Syndrome characterized by development of anicteric ascites ~ 2 weeks to 4 months after hepatic irradiation
Form of venoocclusive disease due to fibrous obliteration of terminal hepatic venules → postsinusoidal obstruction
IMAGING
General Features
CT Findings
MR Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Selected References
De La Pinta Alonso C: Radiation-induced liver disease in the era of SBRT: a review. Expert Rev Gastroenterol Hepatol. 14(12):1195-201, 2020
Koay EJ et al: Radiation-induced liver disease and modern radiotherapy. Semin Radiat Oncol. 28(4):321-31, 2018
Takamatsu S et al: Pathology and images of radiation-induced hepatitis: a review article. Jpn J Radiol. 36(4):241-56, 2018
Munoz-Schuffenegger P et al: Radiation-induced liver toxicity. Semin Radiat Oncol. 27(4):350-7, 2017
Jung J et al: Radiation-induced liver disease after stereotactic body radiotherapy for small hepatocellular carcinoma: clinical and dose-volumetric parameters. Radiat Oncol. 8:249, 2013
Ng SC et al: Patient dosimetry for 90Y selective internal radiation treatment based on 90Y PET imaging. J Appl Clin Med Phys. 14(5):212-21, 2013
Tao C et al: Improved radiotherapy for primary and secondary liver cancer: stereotactic body radiation therapy. Anticancer Res. 32(2):649-55, 2012
Guha C et al: Hepatic radiation toxicity: avoidance and amelioration. Semin Radiat Oncol. 21(4):256-63, 2011
Nalesnik MA et al: Hepatobiliary effects of 90yttrium microsphere therapy for unresectable hepatocellular carcinoma. Hum Pathol. 40(1):125-34, 2009
Neff R et al: The toxicity of liver directed yttrium-90 microspheres in primary and metastatic liver tumors. Cancer Invest. 26(2):173-7, 2008
Szyszko T et al: Management and prevention of adverse effects related to treatment of liver tumours with 90Y microspheres. Nucl Med Commun. 28(1):21-4, 2007
Mori H et al: Radiation-induced liver injury showing low intensity on T2-weighted images noted in Budd-Chiari syndrome. Radiat Med. 20(2):69-76, 2002
Willemart S et al: Acute radiation-induced hepatic injury: evaluation by triphasic contrast enhanced helical CT. Br J Radiol. 73(869):544-6, 2000
Unger EC et al: CT and MR imaging of radiation hepatitis. J Comput Assist Tomogr. 11(2):264-8, 1987
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