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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Definitions
- Cardiac valvular damage secondary to previous radiation, characterized by fibrosis and calcification
- Usually secondary to mediastinal irradiation
- Apparent 10-20 years after radiation
- Regurgitation followed by stenosis
- Left-sided valves are affected due to higher pressures
- Cardiac valvular damage secondary to previous radiation, characterized by fibrosis and calcification
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Echocardiographic Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
Selected References
- Desai MY et al: Radiation-associated cardiac disease: a practical approach to diagnosis and management. JACC Cardiovasc Imaging. 11(8):1132-49, 2018
- Cella L et al: Predicting radiation-induced valvular heart damage. Acta Oncol. 54(10):1796-804, 2015
- Taunk NK et al: Radiation-induced heart disease: pathologic abnormalities and putative mechanisms. Front Oncol. 5:39, 2015
- Jaworski C et al: Cardiac complications of thoracic irradiation. J Am Coll Cardiol. 61(23):2319-28, 2013
- Lancellotti P et al: Expert consensus for multi-modality imaging evaluation of cardiovascular complications of radiotherapy in adults: a report from the European Association of Cardiovascular Imaging and the American Society of Echocardiography. Eur Heart J Cardiovasc Imaging. 14(8):721-40, 2013
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Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Definitions
- Cardiac valvular damage secondary to previous radiation, characterized by fibrosis and calcification
- Usually secondary to mediastinal irradiation
- Apparent 10-20 years after radiation
- Regurgitation followed by stenosis
- Left-sided valves are affected due to higher pressures
- Cardiac valvular damage secondary to previous radiation, characterized by fibrosis and calcification
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Echocardiographic Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
Selected References
- Desai MY et al: Radiation-associated cardiac disease: a practical approach to diagnosis and management. JACC Cardiovasc Imaging. 11(8):1132-49, 2018
- Cella L et al: Predicting radiation-induced valvular heart damage. Acta Oncol. 54(10):1796-804, 2015
- Taunk NK et al: Radiation-induced heart disease: pathologic abnormalities and putative mechanisms. Front Oncol. 5:39, 2015
- Jaworski C et al: Cardiac complications of thoracic irradiation. J Am Coll Cardiol. 61(23):2319-28, 2013
- Lancellotti P et al: Expert consensus for multi-modality imaging evaluation of cardiovascular complications of radiotherapy in adults: a report from the European Association of Cardiovascular Imaging and the American Society of Echocardiography. Eur Heart J Cardiovasc Imaging. 14(8):721-40, 2013
