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Radiation Valvular Disease
Prabhakar Rajiah, MBBS, MD, FRCR, FSCMR
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Definitions

              • Cardiac valvular damage secondary to previous radiation, characterized by fibrosis and calcification
                • Usually secondary to mediastinal irradiation
                • Apparent 10-20 years after radiation
              • Regurgitation followed by stenosis
              • Left-sided valves are affected due to higher pressures

            IMAGING

            • General Features

              • Radiographic Findings

                • CT Findings

                  • MR Findings

                    • Echocardiographic Findings

                      • Imaging Recommendations

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Staging, Grading, & Classification

                              • Gross Pathologic & Surgical Features

                                CLINICAL ISSUES

                                • Presentation

                                  • Demographics

                                    • Natural History & Prognosis

                                      • Treatment

                                        Selected References

                                        1. Desai MY et al: Radiation-associated cardiac disease: a practical approach to diagnosis and management. JACC Cardiovasc Imaging. 11(8):1132-49, 2018
                                        2. Cella L et al: Predicting radiation-induced valvular heart damage. Acta Oncol. 54(10):1796-804, 2015
                                        3. Taunk NK et al: Radiation-induced heart disease: pathologic abnormalities and putative mechanisms. Front Oncol. 5:39, 2015
                                        4. Jaworski C et al: Cardiac complications of thoracic irradiation. J Am Coll Cardiol. 61(23):2319-28, 2013
                                        5. Lancellotti P et al: Expert consensus for multi-modality imaging evaluation of cardiovascular complications of radiotherapy in adults: a report from the European Association of Cardiovascular Imaging and the American Society of Echocardiography. Eur Heart J Cardiovasc Imaging. 14(8):721-40, 2013
                                        Related Anatomy
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                                        Related Differential Diagnoses
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                                        References
                                        Tables

                                        Tables

                                        KEY FACTS

                                        • Terminology

                                          • Imaging

                                            • Top Differential Diagnoses

                                              • Pathology

                                                • Clinical Issues

                                                  TERMINOLOGY

                                                  • Definitions

                                                    • Cardiac valvular damage secondary to previous radiation, characterized by fibrosis and calcification
                                                      • Usually secondary to mediastinal irradiation
                                                      • Apparent 10-20 years after radiation
                                                    • Regurgitation followed by stenosis
                                                    • Left-sided valves are affected due to higher pressures

                                                  IMAGING

                                                  • General Features

                                                    • Radiographic Findings

                                                      • CT Findings

                                                        • MR Findings

                                                          • Echocardiographic Findings

                                                            • Imaging Recommendations

                                                              DIFFERENTIAL DIAGNOSIS

                                                                PATHOLOGY

                                                                • General Features

                                                                  • Staging, Grading, & Classification

                                                                    • Gross Pathologic & Surgical Features

                                                                      CLINICAL ISSUES

                                                                      • Presentation

                                                                        • Demographics

                                                                          • Natural History & Prognosis

                                                                            • Treatment

                                                                              Selected References

                                                                              1. Desai MY et al: Radiation-associated cardiac disease: a practical approach to diagnosis and management. JACC Cardiovasc Imaging. 11(8):1132-49, 2018
                                                                              2. Cella L et al: Predicting radiation-induced valvular heart damage. Acta Oncol. 54(10):1796-804, 2015
                                                                              3. Taunk NK et al: Radiation-induced heart disease: pathologic abnormalities and putative mechanisms. Front Oncol. 5:39, 2015
                                                                              4. Jaworski C et al: Cardiac complications of thoracic irradiation. J Am Coll Cardiol. 61(23):2319-28, 2013
                                                                              5. Lancellotti P et al: Expert consensus for multi-modality imaging evaluation of cardiovascular complications of radiotherapy in adults: a report from the European Association of Cardiovascular Imaging and the American Society of Echocardiography. Eur Heart J Cardiovasc Imaging. 14(8):721-40, 2013