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Rapidly Progressive Osteoarthritis
Derik L. Davis, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          TERMINOLOGY

          • Abbreviations

            • Rapidly progressive osteoarthritis (RPOA)
          • Synonyms

            • Rapidly destructive arthritis, rapidly destructive osteoarthritis, rapidly destructive coxopathy
          • Definitions

            • Rapid development of chondrolysis (cartilage loss) ≥ 2 mm in < 1 year after onset of joint pain in absence of other definable causes

          IMAGING

          • General Features

            • Radiographic Findings

              • CT Findings

                • MR Findings

                  • Imaging Recommendations

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • General Features

                        • Staging, Grading, & Classification

                          CLINICAL ISSUES

                          • Presentation

                            • Demographics

                              • Natural History & Prognosis

                                • Treatment

                                  DIAGNOSTIC CHECKLIST

                                  • Consider

                                    Selected References

                                    1. Wise BL et al: The evolution of nerve growth factor inhibition in clinical medicine. Nat Rev Rheumatol. 17(1):34-46, 2021
                                    2. Yasuda T et al: Bone turnover markers in the early stage of rapidly progressive osteoarthritis of the hip. Eur J Rheumatol. 8(2):57-61, 2020
                                    3. Yasuda T et al: Characterization of rapidly progressive osteoarthritis of the hip in its early stage. Eur J Rheumatol. 7(3):130-4, 2020
                                    4. Karsdal MA et al: Serological biomarker profiles of rapidly progressive osteoarthritis in tanezumab-treated patients. Osteoarthritis Cartilage. 27(3):484-92, 2019
                                    5. Flemming DJ et al: Rapidly progressive osteoarthritis: a review of the clinical and radiologic presentation. Curr Rheumatol Rep. 19(7):42, 2017
                                    6. Wenham CY et al: The role of imaging modalities in the diagnosis, differential diagnosis and clinical assessment of peripheral joint osteoarthritis. Osteoarthritis Cartilage. 22(10):1692-702, 2014
                                    7. Walker EA et al: Rapidly progressive osteoarthritis: biomechanical considerations. Magn Reson Imaging Clin N Am. 19(2):283-94, 2011
                                    Related Anatomy
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                                    Related Differential Diagnoses
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                                    References
                                    Tables

                                    Tables

                                    KEY FACTS

                                    • Terminology

                                      • Imaging

                                        • Top Differential Diagnoses

                                          • Clinical Issues

                                            TERMINOLOGY

                                            • Abbreviations

                                              • Rapidly progressive osteoarthritis (RPOA)
                                            • Synonyms

                                              • Rapidly destructive arthritis, rapidly destructive osteoarthritis, rapidly destructive coxopathy
                                            • Definitions

                                              • Rapid development of chondrolysis (cartilage loss) ≥ 2 mm in < 1 year after onset of joint pain in absence of other definable causes

                                            IMAGING

                                            • General Features

                                              • Radiographic Findings

                                                • CT Findings

                                                  • MR Findings

                                                    • Imaging Recommendations

                                                      DIFFERENTIAL DIAGNOSIS

                                                        PATHOLOGY

                                                        • General Features

                                                          • Staging, Grading, & Classification

                                                            CLINICAL ISSUES

                                                            • Presentation

                                                              • Demographics

                                                                • Natural History & Prognosis

                                                                  • Treatment

                                                                    DIAGNOSTIC CHECKLIST

                                                                    • Consider

                                                                      Selected References

                                                                      1. Wise BL et al: The evolution of nerve growth factor inhibition in clinical medicine. Nat Rev Rheumatol. 17(1):34-46, 2021
                                                                      2. Yasuda T et al: Bone turnover markers in the early stage of rapidly progressive osteoarthritis of the hip. Eur J Rheumatol. 8(2):57-61, 2020
                                                                      3. Yasuda T et al: Characterization of rapidly progressive osteoarthritis of the hip in its early stage. Eur J Rheumatol. 7(3):130-4, 2020
                                                                      4. Karsdal MA et al: Serological biomarker profiles of rapidly progressive osteoarthritis in tanezumab-treated patients. Osteoarthritis Cartilage. 27(3):484-92, 2019
                                                                      5. Flemming DJ et al: Rapidly progressive osteoarthritis: a review of the clinical and radiologic presentation. Curr Rheumatol Rep. 19(7):42, 2017
                                                                      6. Wenham CY et al: The role of imaging modalities in the diagnosis, differential diagnosis and clinical assessment of peripheral joint osteoarthritis. Osteoarthritis Cartilage. 22(10):1692-702, 2014
                                                                      7. Walker EA et al: Rapidly progressive osteoarthritis: biomechanical considerations. Magn Reson Imaging Clin N Am. 19(2):283-94, 2011