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Rathke Cleft Cyst
Karen L. Salzman, MD; Anne G. Osborn, MD, FACR
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          TERMINOLOGY

          • Abbreviations

            • Rathke cleft cyst (RCC)
          • Definitions

            • Nonneoplastic cyst arising from remnants of embryonic Rathke cleft
            • Benign sellar region endodermal cyst lined by ciliated, mucus-producing epithelium

          IMAGING

          • General Features

            • CT Findings

              • MR Findings

                • Imaging Recommendations

                  DIFFERENTIAL DIAGNOSIS

                    PATHOLOGY

                    • General Features

                      • Gross Pathologic & Surgical Features

                        • Microscopic Features

                          CLINICAL ISSUES

                          • Presentation

                            • Demographics

                              • Natural History & Prognosis

                                • Treatment

                                  DIAGNOSTIC CHECKLIST

                                  • Consider

                                    • Image Interpretation Pearls

                                      Selected References

                                      1. Alomari AK et al: Craniopharyngioma arising in a Rathke's cleft cyst: case report. J Neurosurg Pediatr. 15(3):250-4, 2015
                                      2. Chotai S et al: Characteristics of Rathke's cleft cyst based on cyst location with a primary focus on recurrence after resection. J Neurosurg. 1-10, 2015
                                      3. Esteves C et al: Pituitary incidentalomas: analysis of a neuroradiological cohort. Pituitary. ePub, 2015
                                      4. Han SJ et al: Rathke's cleft cysts: review of natural history and surgical outcomes. J Neurooncol. 117(2):197-203, 2014
                                      5. Ogawa Y et al: Spontaneous alteration from Rathke's cleft cyst to craniopharyngioma--possible involvement of transformation between these pathologies. Endocr Pathol. 25(4):422-6, 2014
                                      6. Oh YJ et al: Clinical and radiological findings of incidental Rathke's cleft cysts in children and adolescents. Ann Pediatr Endocrinol Metab. 19(1):20-6, 2014
                                      7. Kitajima M et al: Differentiation of common large sellar-suprasellar masses effect of artificial neural network on radiologists' diagnosis performance. Acad Radiol. 16(3):313-20, 2009
                                      8. Binning MJ et al: Hemorrhagic and nonhemorrhagic Rathke cleft cysts mimicking pituitary apoplexy. J Neurosurg. 108(1):3-8, 2008
                                      9. Glezer A et al: Rare sellar lesions. Endocrinol Metab Clin North Am. 37(1):195-211, x, 2008
                                      10. Maruyama H et al: Rathke's cleft cyst with short-term size changes in response to glucocorticoid replacement. Endocr J. 55(2):425-8, 2008
                                      11. Rao VJ et al: Imaging characteristics of common suprasellar lesions with emphasis on MRI findings. Clin Radiol. 63(8):939-47, 2008
                                      12. Kunii N et al: Rathke's cleft cysts: differentiation from other cystic lesions in the pituitary fossa by use of single-shot fast spin-echo diffusion-weighted MR imaging. Acta Neurochir (Wien). 149(8):759-69; discussion 769, 2007
                                      13. Kim JE et al: Surgical treatment of symptomatic Rathke cleft cysts: clinical features and results with special attention to recurrence. J Neurosurg. 100(1):33-40, 2004
                                      14. Xin W et al: Differential expression of cytokeratins 8 and 20 distinguishes craniopharyngioma from rathke cleft cyst. Arch Pathol Lab Med. 126(10):1174-8, 2002
                                      15. Byun WM et al: MR imaging findings of Rathke's cleft cysts: significance of intracystic nodules. AJNR Am J Neuroradiol. 21(3):485-8, 2000
                                      16. Naylor MF et al: Rathke cleft cyst: CT, MR, and pathology of 23 cases. J Comput Assist Tomogr. 19(6):853-9, 1995
                                      Related Anatomy
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                                      Related Differential Diagnoses
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                                      References
                                      Tables

                                      Tables

                                      KEY FACTS

                                      • Terminology

                                        • Imaging

                                          • Top Differential Diagnoses

                                            • Clinical Issues

                                              TERMINOLOGY

                                              • Abbreviations

                                                • Rathke cleft cyst (RCC)
                                              • Definitions

                                                • Nonneoplastic cyst arising from remnants of embryonic Rathke cleft
                                                • Benign sellar region endodermal cyst lined by ciliated, mucus-producing epithelium

                                              IMAGING

                                              • General Features

                                                • CT Findings

                                                  • MR Findings

                                                    • Imaging Recommendations

                                                      DIFFERENTIAL DIAGNOSIS

                                                        PATHOLOGY

                                                        • General Features

                                                          • Gross Pathologic & Surgical Features

                                                            • Microscopic Features

                                                              CLINICAL ISSUES

                                                              • Presentation

                                                                • Demographics

                                                                  • Natural History & Prognosis

                                                                    • Treatment

                                                                      DIAGNOSTIC CHECKLIST

                                                                      • Consider

                                                                        • Image Interpretation Pearls

                                                                          Selected References

                                                                          1. Alomari AK et al: Craniopharyngioma arising in a Rathke's cleft cyst: case report. J Neurosurg Pediatr. 15(3):250-4, 2015
                                                                          2. Chotai S et al: Characteristics of Rathke's cleft cyst based on cyst location with a primary focus on recurrence after resection. J Neurosurg. 1-10, 2015
                                                                          3. Esteves C et al: Pituitary incidentalomas: analysis of a neuroradiological cohort. Pituitary. ePub, 2015
                                                                          4. Han SJ et al: Rathke's cleft cysts: review of natural history and surgical outcomes. J Neurooncol. 117(2):197-203, 2014
                                                                          5. Ogawa Y et al: Spontaneous alteration from Rathke's cleft cyst to craniopharyngioma--possible involvement of transformation between these pathologies. Endocr Pathol. 25(4):422-6, 2014
                                                                          6. Oh YJ et al: Clinical and radiological findings of incidental Rathke's cleft cysts in children and adolescents. Ann Pediatr Endocrinol Metab. 19(1):20-6, 2014
                                                                          7. Kitajima M et al: Differentiation of common large sellar-suprasellar masses effect of artificial neural network on radiologists' diagnosis performance. Acad Radiol. 16(3):313-20, 2009
                                                                          8. Binning MJ et al: Hemorrhagic and nonhemorrhagic Rathke cleft cysts mimicking pituitary apoplexy. J Neurosurg. 108(1):3-8, 2008
                                                                          9. Glezer A et al: Rare sellar lesions. Endocrinol Metab Clin North Am. 37(1):195-211, x, 2008
                                                                          10. Maruyama H et al: Rathke's cleft cyst with short-term size changes in response to glucocorticoid replacement. Endocr J. 55(2):425-8, 2008
                                                                          11. Rao VJ et al: Imaging characteristics of common suprasellar lesions with emphasis on MRI findings. Clin Radiol. 63(8):939-47, 2008
                                                                          12. Kunii N et al: Rathke's cleft cysts: differentiation from other cystic lesions in the pituitary fossa by use of single-shot fast spin-echo diffusion-weighted MR imaging. Acta Neurochir (Wien). 149(8):759-69; discussion 769, 2007
                                                                          13. Kim JE et al: Surgical treatment of symptomatic Rathke cleft cysts: clinical features and results with special attention to recurrence. J Neurosurg. 100(1):33-40, 2004
                                                                          14. Xin W et al: Differential expression of cytokeratins 8 and 20 distinguishes craniopharyngioma from rathke cleft cyst. Arch Pathol Lab Med. 126(10):1174-8, 2002
                                                                          15. Byun WM et al: MR imaging findings of Rathke's cleft cysts: significance of intracystic nodules. AJNR Am J Neuroradiol. 21(3):485-8, 2000
                                                                          16. Naylor MF et al: Rathke cleft cyst: CT, MR, and pathology of 23 cases. J Comput Assist Tomogr. 19(6):853-9, 1995