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KEY FACTS
Terminology
Imaging Anatomy
Evaluation of Response
TERMINOLOGY
Abbreviations
- Response evaluation criteria in solid tumors (RECIST)
Definitions
- Revised response criteria published in 2009
- Updated previous RECIST criteria
Rationale and Key Concepts
- Patient eligibility
- Patients with measurable disease at baseline
- Measurable disease: Indicates presence of at least 1 measurable lesion
- Enrolled in protocols where objective tumor response is primary endpoint
- Patients with measurable disease at baseline
- Assess disease at baseline
- Evaluate for measurable disease
- Identify target and nontarget lesions
- Measure target lesions
- Tumor burden: Sum of target lesions
- Assess disease at follow-up
- Measure target lesions
- Assess nontarget lesions
- Identify new lesions
- Calculate time point response
- Patient eligibility
Significant Differences Between RECIST & RECIST 1.1
- Change in definition of
- Tumor burden
- Measurement of lymph nodes
- Definition of progressive disease
- Nonmeasurable progressive disease
- Confirmation of response
- New lesions
- Change in definition of
IMAGING ANATOMY
Measurable and Nonmeasurable Disease
Imaging Protocols
Baseline Evaluation
Evaluation of Response
Key Concepts
Target Lesion Evaluation
New Lesions
Overall Response
FDG PET & PET/CT
Missing Assessments and Nonevaluable Designation
Lesion Recurrence
Confirmation of Response
Selected References
- Litière S et al: The components of progression as explanatory variables for overall survival in the Response Evaluation Criteria in Solid Tumours 1.1 database. Eur J Cancer. 50(10):1847-53, 2014
- Nishino M et al: Revised RECIST guideline version 1.1: What oncologists want to know and what radiologists need to know. AJR Am J Roentgenol. 195(2):281-9, 2010
- van Persijn van Meerten EL et al: RECIST revised: implications for the radiologist. A review article on the modified RECIST guideline. Eur Radiol. 20(6):1456-67, 2010
- Eisenhauer EA et al: New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). Eur J Cancer. 45(2):228-47, 2009
- Eisenhauer EA et al: Response assessment in solid tumours (RECIST) and supporting papers (version 1.1). Eur J. Cancer. 45(2):225-310, 2009
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References
Tables
Tables
KEY FACTS
Terminology
Imaging Anatomy
Evaluation of Response
TERMINOLOGY
Abbreviations
- Response evaluation criteria in solid tumors (RECIST)
Definitions
- Revised response criteria published in 2009
- Updated previous RECIST criteria
Rationale and Key Concepts
- Patient eligibility
- Patients with measurable disease at baseline
- Measurable disease: Indicates presence of at least 1 measurable lesion
- Enrolled in protocols where objective tumor response is primary endpoint
- Patients with measurable disease at baseline
- Assess disease at baseline
- Evaluate for measurable disease
- Identify target and nontarget lesions
- Measure target lesions
- Tumor burden: Sum of target lesions
- Assess disease at follow-up
- Measure target lesions
- Assess nontarget lesions
- Identify new lesions
- Calculate time point response
- Patient eligibility
Significant Differences Between RECIST & RECIST 1.1
- Change in definition of
- Tumor burden
- Measurement of lymph nodes
- Definition of progressive disease
- Nonmeasurable progressive disease
- Confirmation of response
- New lesions
- Change in definition of
IMAGING ANATOMY
Measurable and Nonmeasurable Disease
Imaging Protocols
Baseline Evaluation
Evaluation of Response
Key Concepts
Target Lesion Evaluation
New Lesions
Overall Response
FDG PET & PET/CT
Missing Assessments and Nonevaluable Designation
Lesion Recurrence
Confirmation of Response
Selected References
- Litière S et al: The components of progression as explanatory variables for overall survival in the Response Evaluation Criteria in Solid Tumours 1.1 database. Eur J Cancer. 50(10):1847-53, 2014
- Nishino M et al: Revised RECIST guideline version 1.1: What oncologists want to know and what radiologists need to know. AJR Am J Roentgenol. 195(2):281-9, 2010
- van Persijn van Meerten EL et al: RECIST revised: implications for the radiologist. A review article on the modified RECIST guideline. Eur Radiol. 20(6):1456-67, 2010
- Eisenhauer EA et al: New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). Eur J Cancer. 45(2):228-47, 2009
- Eisenhauer EA et al: Response assessment in solid tumours (RECIST) and supporting papers (version 1.1). Eur J. Cancer. 45(2):225-310, 2009
