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Regional Distribution of Calcifications
Wendie A. Berg, MD, PhD
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KEY FACTS

  • Terminology

    • Imaging

      • Diagnostic Checklist

        TERMINOLOGY

        • Definitions

          • Distribution of calcifications (Ca⁺⁺) over large (> 2 cm) span, not in expected distribution of duct
            • Can involve solitary or multiple regions
            • May involve most of 1 quadrant or > 1 quadrant
          • Use "grouped" when ≤ 2 cm span and not in distribution of duct(s)

        IMAGING

        • General Features

          • Mammographic Findings

            • Ultrasonographic Findings

              • MR Findings

                • Nuclear Medicine Findings

                  • Image-Guided Biopsy

                    • Imaging Recommendations

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          CLINICAL ISSUES

                          • Presentation

                            • Treatment

                              DIAGNOSTIC CHECKLIST

                              • Consider

                                • Image Interpretation Pearls

                                  • Reporting Tips

                                    Selected References

                                    1. Kaltenbach B et al: A matrix of morphology and distribution of calcifications in the breast: Analysis of 849 vacuum-assisted biopsies. Eur J Radiol. 86:221-226, 2017
                                    2. Raj SD et al: Stereotactic biopsy of segmental breast calcifications: Is sampling of anterior and posterior components necessary? Acad Radiol. 23(6):682-6, 2016
                                    3. Chang Sen LQ et al: Core breast biopsies showing lobular carcinoma in situ should be excised and surveillance is reasonable for atypical lobular hyperplasia. AJR Am J Roentgenol. 207(5):1132-1145, 2016
                                    4. Kim SY et al: Evaluation of malignancy risk stratification of microcalcifications detected on mammography: a study based on the 5th edition of BI-RADS. Ann Surg Oncol. 22(9):2895-901, 2015
                                    5. Sickles EA et al: Breast Imaging Reporting and Data System, BI-RADS: Mammography. 5th ed. Reston: American College of Radiology, 2013
                                    6. Bent CK et al: The positive predictive value of BI-RADS microcalcification descriptors and final assessment categories. AJR Am J Roentgenol. 194(5):1378-83, 2010
                                    7. Burnside ES et al: Use of microcalcification descriptors in BI-RADS 4th edition to stratify risk of malignancy. Radiology. 242(2):388-95, 2007
                                    8. Soo MS et al: Sonographic detection and sonographically guided biopsy of breast microcalcifications. AJR Am J Roentgenol. 180(4):941-8, 2003
                                    9. Liberman L et al: Bracketing wires for preoperative breast needle localization. AJR Am J Roentgenol. 177(3):565-72, 2001
                                    10. Moon WK et al: US of mammographically detected clustered microcalcifications. Radiology. 217(3):849-54, 2000
                                    11. Liberman L et al: The breast imaging reporting and data system: positive predictive value of mammographic features and final assessment categories. AJR Am J Roentgenol. 171(1):35-40, 1998
                                    12. Gluck BS et al: Microcalcifications on postoperative mammograms as an indicator of adequacy of tumor excision. Radiology. 188(2):469-72, 1993
                                    13. Holland R et al: Extent, distribution, and mammographic/histological correlations of breast ductal carcinoma in situ. Lancet. 335(8688):519-22, 1990
                                    Related Anatomy
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                                    Related Differential Diagnoses
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                                    References
                                    Tables

                                    Tables

                                    KEY FACTS

                                    • Terminology

                                      • Imaging

                                        • Diagnostic Checklist

                                          TERMINOLOGY

                                          • Definitions

                                            • Distribution of calcifications (Ca⁺⁺) over large (> 2 cm) span, not in expected distribution of duct
                                              • Can involve solitary or multiple regions
                                              • May involve most of 1 quadrant or > 1 quadrant
                                            • Use "grouped" when ≤ 2 cm span and not in distribution of duct(s)

                                          IMAGING

                                          • General Features

                                            • Mammographic Findings

                                              • Ultrasonographic Findings

                                                • MR Findings

                                                  • Nuclear Medicine Findings

                                                    • Image-Guided Biopsy

                                                      • Imaging Recommendations

                                                        DIFFERENTIAL DIAGNOSIS

                                                          PATHOLOGY

                                                          • General Features

                                                            CLINICAL ISSUES

                                                            • Presentation

                                                              • Treatment

                                                                DIAGNOSTIC CHECKLIST

                                                                • Consider

                                                                  • Image Interpretation Pearls

                                                                    • Reporting Tips

                                                                      Selected References

                                                                      1. Kaltenbach B et al: A matrix of morphology and distribution of calcifications in the breast: Analysis of 849 vacuum-assisted biopsies. Eur J Radiol. 86:221-226, 2017
                                                                      2. Raj SD et al: Stereotactic biopsy of segmental breast calcifications: Is sampling of anterior and posterior components necessary? Acad Radiol. 23(6):682-6, 2016
                                                                      3. Chang Sen LQ et al: Core breast biopsies showing lobular carcinoma in situ should be excised and surveillance is reasonable for atypical lobular hyperplasia. AJR Am J Roentgenol. 207(5):1132-1145, 2016
                                                                      4. Kim SY et al: Evaluation of malignancy risk stratification of microcalcifications detected on mammography: a study based on the 5th edition of BI-RADS. Ann Surg Oncol. 22(9):2895-901, 2015
                                                                      5. Sickles EA et al: Breast Imaging Reporting and Data System, BI-RADS: Mammography. 5th ed. Reston: American College of Radiology, 2013
                                                                      6. Bent CK et al: The positive predictive value of BI-RADS microcalcification descriptors and final assessment categories. AJR Am J Roentgenol. 194(5):1378-83, 2010
                                                                      7. Burnside ES et al: Use of microcalcification descriptors in BI-RADS 4th edition to stratify risk of malignancy. Radiology. 242(2):388-95, 2007
                                                                      8. Soo MS et al: Sonographic detection and sonographically guided biopsy of breast microcalcifications. AJR Am J Roentgenol. 180(4):941-8, 2003
                                                                      9. Liberman L et al: Bracketing wires for preoperative breast needle localization. AJR Am J Roentgenol. 177(3):565-72, 2001
                                                                      10. Moon WK et al: US of mammographically detected clustered microcalcifications. Radiology. 217(3):849-54, 2000
                                                                      11. Liberman L et al: The breast imaging reporting and data system: positive predictive value of mammographic features and final assessment categories. AJR Am J Roentgenol. 171(1):35-40, 1998
                                                                      12. Gluck BS et al: Microcalcifications on postoperative mammograms as an indicator of adequacy of tumor excision. Radiology. 188(2):469-72, 1993
                                                                      13. Holland R et al: Extent, distribution, and mammographic/histological correlations of breast ductal carcinoma in situ. Lancet. 335(8688):519-22, 1990