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Renal Cell Carcinoma
Brad Perry, MD; Paige Bennett, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Definitions

              • Renal cell carcinoma (RCC): Carcinoma of renal tubular epithelium
                • Commonly located in renal cortex
                • Exophytic
                  • Originates from lining of proximal convoluted tubule
                • Can be bilateral (2%)
                  • Especially individuals with genetic syndromes (von Hippel-Lindau)
                • 10% calcified, often irregular
                • 2-5% cystic

            IMAGING

            • F-18 FDG PET/CT Findings

              • Ga-68 PSMA PET/CT Findings

                • MR Findings

                  • Nuclear Medicine Findings

                    • CT Findings

                      • Imaging Recommendations

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • Staging, Grading, & Classification

                            CLINICAL ISSUES

                            • Presentation

                              • Demographics

                                • Natural History & Prognosis

                                  • Treatment

                                    DIAGNOSTIC CHECKLIST

                                    • Consider

                                      • Image Interpretation Pearls

                                        Selected References

                                        1. Pankowska V et al: FDG PET/CT as a survival prognostic factor in patients with advanced renal cell carcinoma. Clin Exp Med. 19(1):143-8, 2019
                                        2. Takagi K et al: Retroperitoneal lipogranuloma mimicking recurrence of renal cell carcinoma after laparoscopic partial nephrectomy. Urol Case Rep. 26:100940, 2019
                                        3. Liu Y: The place of FDG PET/CT in renal cell carcinoma: value and limitations. Front Oncol. 6:201, 2016
                                        4. Demirci E et al: (68)Ga-PSMA PET/CT imaging of metastatic clear cell renal cell carcinoma. Eur J Nucl Med Mol Imaging. 41(7):1461-2, 2014
                                        5. Nakatani K et al: The potential clinical value of FDG-PET for recurrent renal cell carcinoma. Eur J Radiol. 79(1):29-35, 2011
                                        6. Kumar R et al: Role of FDG PET-CT in recurrent renal cell carcinoma. Nucl Med Commun. 31(10):844-50, 2010
                                        Related Anatomy
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                                        Related Differential Diagnoses
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                                        References
                                        Tables

                                        Tables

                                        KEY FACTS

                                        • Terminology

                                          • Imaging

                                            • Top Differential Diagnoses

                                              • Pathology

                                                • Clinical Issues

                                                  TERMINOLOGY

                                                  • Definitions

                                                    • Renal cell carcinoma (RCC): Carcinoma of renal tubular epithelium
                                                      • Commonly located in renal cortex
                                                      • Exophytic
                                                        • Originates from lining of proximal convoluted tubule
                                                      • Can be bilateral (2%)
                                                        • Especially individuals with genetic syndromes (von Hippel-Lindau)
                                                      • 10% calcified, often irregular
                                                      • 2-5% cystic

                                                  IMAGING

                                                  • F-18 FDG PET/CT Findings

                                                    • Ga-68 PSMA PET/CT Findings

                                                      • MR Findings

                                                        • Nuclear Medicine Findings

                                                          • CT Findings

                                                            • Imaging Recommendations

                                                              DIFFERENTIAL DIAGNOSIS

                                                                PATHOLOGY

                                                                • Staging, Grading, & Classification

                                                                  CLINICAL ISSUES

                                                                  • Presentation

                                                                    • Demographics

                                                                      • Natural History & Prognosis

                                                                        • Treatment

                                                                          DIAGNOSTIC CHECKLIST

                                                                          • Consider

                                                                            • Image Interpretation Pearls

                                                                              Selected References

                                                                              1. Pankowska V et al: FDG PET/CT as a survival prognostic factor in patients with advanced renal cell carcinoma. Clin Exp Med. 19(1):143-8, 2019
                                                                              2. Takagi K et al: Retroperitoneal lipogranuloma mimicking recurrence of renal cell carcinoma after laparoscopic partial nephrectomy. Urol Case Rep. 26:100940, 2019
                                                                              3. Liu Y: The place of FDG PET/CT in renal cell carcinoma: value and limitations. Front Oncol. 6:201, 2016
                                                                              4. Demirci E et al: (68)Ga-PSMA PET/CT imaging of metastatic clear cell renal cell carcinoma. Eur J Nucl Med Mol Imaging. 41(7):1461-2, 2014
                                                                              5. Nakatani K et al: The potential clinical value of FDG-PET for recurrent renal cell carcinoma. Eur J Radiol. 79(1):29-35, 2011
                                                                              6. Kumar R et al: Role of FDG PET-CT in recurrent renal cell carcinoma. Nucl Med Commun. 31(10):844-50, 2010