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Renal Cell Carcinoma
Ethan A. Smith, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Abbreviations

              • Renal cell carcinoma (RCC)
            • Synonyms

              • tRCC or TFE RCC = translocation subtype (most common) of RCC
            • Definitions

              • Malignant renal tumor that is more common in adolescents & young adults
                • 2-6% of renal malignancies in children

            IMAGING

            • General Features

              • Ultrasonographic Findings

                • CT Findings

                  • MR Findings

                    • Imaging Recommendations

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Staging, Grading, & Classification

                            CLINICAL ISSUES

                            • Presentation

                              • Demographics

                                • Natural History & Prognosis

                                  • Treatment

                                    DIAGNOSTIC CHECKLIST

                                    • Image Interpretation Pearls

                                      Selected References

                                      1. Geller JI et al: A prospective study of pediatric and adolescent renal cell carcinoma: a report from the Children's Oncology Group AREN0321 study. Cancer. 126(23):5156-64, 2020
                                      2. Ray S et al: Pediatric and young adult renal cell carcinoma. Pediatr Blood Cancer. 67(11):e28675, 2020
                                      3. Ambalavanan M et al: Treatment of advanced pediatric renal cell carcinoma. Pediatr Blood Cancer. 66(8):e27766, 2019
                                      4. Chen X et al: Renal cell carcinoma associated with Xp11.2 translocation/TFE gene fusion: imaging findings in 21 patients. Eur Radiol. 27(2):543-52, 2017
                                      5. Chung EM et al: Renal tumors of childhood: radiologic-pathologic correlation part 2. The 2nd decade: from the Radiologic Pathology Archives. Radiographics. 37(5):1538-58, 2017
                                      6. Geller JI et al: Characterization of adolescent and pediatric renal cell carcinoma: a report from the Children's Oncology Group study AREN03B2. Cancer. 121(14):2457-64, 2015
                                      7. Downey RT et al: CT and MRI appearances and radiologic staging of pediatric renal cell carcinoma. Pediatr Radiol. 42(4):410-7; quiz 513-4, 2012
                                      Related Anatomy
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                                      Related Differential Diagnoses
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                                      References
                                      Tables

                                      Tables

                                      KEY FACTS

                                      • Terminology

                                        • Imaging

                                          • Top Differential Diagnoses

                                            • Pathology

                                              • Clinical Issues

                                                TERMINOLOGY

                                                • Abbreviations

                                                  • Renal cell carcinoma (RCC)
                                                • Synonyms

                                                  • tRCC or TFE RCC = translocation subtype (most common) of RCC
                                                • Definitions

                                                  • Malignant renal tumor that is more common in adolescents & young adults
                                                    • 2-6% of renal malignancies in children

                                                IMAGING

                                                • General Features

                                                  • Ultrasonographic Findings

                                                    • CT Findings

                                                      • MR Findings

                                                        • Imaging Recommendations

                                                          DIFFERENTIAL DIAGNOSIS

                                                            PATHOLOGY

                                                            • General Features

                                                              • Staging, Grading, & Classification

                                                                CLINICAL ISSUES

                                                                • Presentation

                                                                  • Demographics

                                                                    • Natural History & Prognosis

                                                                      • Treatment

                                                                        DIAGNOSTIC CHECKLIST

                                                                        • Image Interpretation Pearls

                                                                          Selected References

                                                                          1. Geller JI et al: A prospective study of pediatric and adolescent renal cell carcinoma: a report from the Children's Oncology Group AREN0321 study. Cancer. 126(23):5156-64, 2020
                                                                          2. Ray S et al: Pediatric and young adult renal cell carcinoma. Pediatr Blood Cancer. 67(11):e28675, 2020
                                                                          3. Ambalavanan M et al: Treatment of advanced pediatric renal cell carcinoma. Pediatr Blood Cancer. 66(8):e27766, 2019
                                                                          4. Chen X et al: Renal cell carcinoma associated with Xp11.2 translocation/TFE gene fusion: imaging findings in 21 patients. Eur Radiol. 27(2):543-52, 2017
                                                                          5. Chung EM et al: Renal tumors of childhood: radiologic-pathologic correlation part 2. The 2nd decade: from the Radiologic Pathology Archives. Radiographics. 37(5):1538-58, 2017
                                                                          6. Geller JI et al: Characterization of adolescent and pediatric renal cell carcinoma: a report from the Children's Oncology Group study AREN03B2. Cancer. 121(14):2457-64, 2015
                                                                          7. Downey RT et al: CT and MRI appearances and radiologic staging of pediatric renal cell carcinoma. Pediatr Radiol. 42(4):410-7; quiz 513-4, 2012