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Renal Osteodystrophy
Kevin R. Moore, MD; Jeffrey S. Ross, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Abbreviations

                • Renal osteodystrophy (OD)
              • Definitions

                • Chronic kidney disease-mineral and bone disorder (CKD-MBD): Constellation of abnormalities seen in progressive kidney disease, including metabolic abnormalities, disturbances in bone modeling and remodeling, and extraskeletal calcification in arteries and soft tissues
                • Renal osteodystrophy (OD): Only defines bone pathology associated with CKD

              IMAGING

              • General Features

                • Radiographic Findings

                  • CT Findings

                    • MR Findings

                      • Nuclear Medicine Findings

                        • Imaging Recommendations

                          DIFFERENTIAL DIAGNOSIS

                            PATHOLOGY

                            • General Features

                              • Gross Pathologic & Surgical Features

                                • Microscopic Features

                                  CLINICAL ISSUES

                                  • Presentation

                                    • Demographics

                                      • Natural History & Prognosis

                                        • Treatment

                                          DIAGNOSTIC CHECKLIST

                                          • Consider

                                            Selected References

                                            1. Sharma AK et al: Deterioration of cortical bone microarchitecture: critical component of renal osteodystrophy evaluation. Am J Nephrol. 47(6):376-84, 2018
                                            2. Ketteler M et al: Executive summary of the 2017 KDIGO Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD) Guideline Update: what's changed and why it matters. Kidney Int. 92(1):26-36, 2017
                                            3. Bover J et al: Adynamic bone disease: from bone to vessels in chronic kidney disease. Semin Nephrol. 34(6):626-40, 2014
                                            4. Kemper MJ et al: Renal osteodystrophy in children: pathogenesis, diagnosis and treatment. Curr Opin Pediatr. 26(2):180-6, 2014
                                            5. Torres PU et al: When, how, and why a bone biopsy should be performed in patients with chronic kidney disease. Semin Nephrol. 34(6):612-25, 2014
                                            6. Moorthi RN et al: Recent advances in the noninvasive diagnosis of renal osteodystrophy. Kidney Int. 84(5):886-94, 2013
                                            7. Sundaram M: Founders lecture 2007: Metabolic bone disease: what has changed in 30 years? Skeletal Radiol. 38(9):841-53, 2009
                                            8. Bardin T: Musculoskeletal manifestations of chronic renal failure. Curr Opin Rheumatol. 15(1):48-54, 2003
                                            9. Jevtic V: Imaging of renal osteodystrophy. Eur J Radiol. 46(2):85-95, 2003
                                            10. Paderni S et al: Vertebral localization of a brown tumor: description of a case and review of the literature. Chir Organi Mov. 88(1):83-91, 2003
                                            11. Spasovski GB et al: Spectrum of renal bone disease in end-stage renal failure patients not yet on dialysis. Nephrol Dial Transplant. 18(6):1159-66, 2003
                                            Related Anatomy
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                                            Related Differential Diagnoses
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                                            References
                                            Tables

                                            Tables

                                            KEY FACTS

                                            • Terminology

                                              • Imaging

                                                • Top Differential Diagnoses

                                                  • Pathology

                                                    • Clinical Issues

                                                      • Diagnostic Checklist

                                                        TERMINOLOGY

                                                        • Abbreviations

                                                          • Renal osteodystrophy (OD)
                                                        • Definitions

                                                          • Chronic kidney disease-mineral and bone disorder (CKD-MBD): Constellation of abnormalities seen in progressive kidney disease, including metabolic abnormalities, disturbances in bone modeling and remodeling, and extraskeletal calcification in arteries and soft tissues
                                                          • Renal osteodystrophy (OD): Only defines bone pathology associated with CKD

                                                        IMAGING

                                                        • General Features

                                                          • Radiographic Findings

                                                            • CT Findings

                                                              • MR Findings

                                                                • Nuclear Medicine Findings

                                                                  • Imaging Recommendations

                                                                    DIFFERENTIAL DIAGNOSIS

                                                                      PATHOLOGY

                                                                      • General Features

                                                                        • Gross Pathologic & Surgical Features

                                                                          • Microscopic Features

                                                                            CLINICAL ISSUES

                                                                            • Presentation

                                                                              • Demographics

                                                                                • Natural History & Prognosis

                                                                                  • Treatment

                                                                                    DIAGNOSTIC CHECKLIST

                                                                                    • Consider

                                                                                      Selected References

                                                                                      1. Sharma AK et al: Deterioration of cortical bone microarchitecture: critical component of renal osteodystrophy evaluation. Am J Nephrol. 47(6):376-84, 2018
                                                                                      2. Ketteler M et al: Executive summary of the 2017 KDIGO Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD) Guideline Update: what's changed and why it matters. Kidney Int. 92(1):26-36, 2017
                                                                                      3. Bover J et al: Adynamic bone disease: from bone to vessels in chronic kidney disease. Semin Nephrol. 34(6):626-40, 2014
                                                                                      4. Kemper MJ et al: Renal osteodystrophy in children: pathogenesis, diagnosis and treatment. Curr Opin Pediatr. 26(2):180-6, 2014
                                                                                      5. Torres PU et al: When, how, and why a bone biopsy should be performed in patients with chronic kidney disease. Semin Nephrol. 34(6):612-25, 2014
                                                                                      6. Moorthi RN et al: Recent advances in the noninvasive diagnosis of renal osteodystrophy. Kidney Int. 84(5):886-94, 2013
                                                                                      7. Sundaram M: Founders lecture 2007: Metabolic bone disease: what has changed in 30 years? Skeletal Radiol. 38(9):841-53, 2009
                                                                                      8. Bardin T: Musculoskeletal manifestations of chronic renal failure. Curr Opin Rheumatol. 15(1):48-54, 2003
                                                                                      9. Jevtic V: Imaging of renal osteodystrophy. Eur J Radiol. 46(2):85-95, 2003
                                                                                      10. Paderni S et al: Vertebral localization of a brown tumor: description of a case and review of the literature. Chir Organi Mov. 88(1):83-91, 2003
                                                                                      11. Spasovski GB et al: Spectrum of renal bone disease in end-stage renal failure patients not yet on dialysis. Nephrol Dial Transplant. 18(6):1159-66, 2003