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Renal Osteodystrophy
Julia R. Crim, MD; Jeffrey S. Ross, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Abbreviations

              • Renal osteodystrophy (OD)
            • Definitions

              • Chronic kidney disease-mineral and bone disorder (CKD-MBD): Constellation of abnormalities seen in progressive kidney disease, including metabolic abnormalities, disturbances in bone modeling and remodeling, and extraskeletal calcification in arteries and soft tissues
              • Renal osteodystrophy (OD): Only defines bone pathology associated with CKD

            IMAGING

            • General Features

              • Radiographic Findings

                • MR Findings

                  • Nuclear Medicine Findings

                    • Imaging Recommendations

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Gross Pathologic & Surgical Features

                            • Microscopic Features

                              CLINICAL ISSUES

                              • Presentation

                                • Demographics

                                  • Natural History & Prognosis

                                    • Treatment

                                      Selected References

                                      1. Bover J et al: Adynamic Bone Disease: From Bone to Vessels in Chronic Kidney Disease. Semin Nephrol. 34(6):626-640, 2014
                                      2. Kemper MJ et al: Renal osteodystrophy in children: pathogenesis, diagnosis and treatment. Curr Opin Pediatr. 26(2):180-6, 2014
                                      3. Torres PU et al: When, How, and Why a Bone Biopsy Should Be Performed in Patients With Chronic Kidney Disease. Semin Nephrol. 34(6):612-625, 2014
                                      4. Moorthi RN et al: Recent advances in the noninvasive diagnosis of renal osteodystrophy. Kidney Int. 84(5):886-94, 2013
                                      5. Sundaram M: Founders lecture 2007: Metabolic bone disease: what has changed in 30 years? Skeletal Radiol. 38(9):841-53, 2009
                                      6. Bardin T: Musculoskeletal manifestations of chronic renal failure. Curr Opin Rheumatol. 15(1):48-54, 2003
                                      7. Jevtic V: Imaging of renal osteodystrophy. Eur J Radiol. 46(2):85-95, 2003
                                      8. Paderni S et al: Vertebral localization of a brown tumor: description of a case and review of the literature. Chir Organi Mov. 88(1):83-91, 2003
                                      9. Spasovski GB et al: Spectrum of renal bone disease in end-stage renal failure patients not yet on dialysis. Nephrol Dial Transplant. 18(6):1159-66, 2003
                                      Related Anatomy
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                                      Related Differential Diagnoses
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                                      References
                                      Tables

                                      Tables

                                      KEY FACTS

                                      • Terminology

                                        • Imaging

                                          • Top Differential Diagnoses

                                            • Pathology

                                              • Clinical Issues

                                                TERMINOLOGY

                                                • Abbreviations

                                                  • Renal osteodystrophy (OD)
                                                • Definitions

                                                  • Chronic kidney disease-mineral and bone disorder (CKD-MBD): Constellation of abnormalities seen in progressive kidney disease, including metabolic abnormalities, disturbances in bone modeling and remodeling, and extraskeletal calcification in arteries and soft tissues
                                                  • Renal osteodystrophy (OD): Only defines bone pathology associated with CKD

                                                IMAGING

                                                • General Features

                                                  • Radiographic Findings

                                                    • MR Findings

                                                      • Nuclear Medicine Findings

                                                        • Imaging Recommendations

                                                          DIFFERENTIAL DIAGNOSIS

                                                            PATHOLOGY

                                                            • General Features

                                                              • Gross Pathologic & Surgical Features

                                                                • Microscopic Features

                                                                  CLINICAL ISSUES

                                                                  • Presentation

                                                                    • Demographics

                                                                      • Natural History & Prognosis

                                                                        • Treatment

                                                                          Selected References

                                                                          1. Bover J et al: Adynamic Bone Disease: From Bone to Vessels in Chronic Kidney Disease. Semin Nephrol. 34(6):626-640, 2014
                                                                          2. Kemper MJ et al: Renal osteodystrophy in children: pathogenesis, diagnosis and treatment. Curr Opin Pediatr. 26(2):180-6, 2014
                                                                          3. Torres PU et al: When, How, and Why a Bone Biopsy Should Be Performed in Patients With Chronic Kidney Disease. Semin Nephrol. 34(6):612-625, 2014
                                                                          4. Moorthi RN et al: Recent advances in the noninvasive diagnosis of renal osteodystrophy. Kidney Int. 84(5):886-94, 2013
                                                                          5. Sundaram M: Founders lecture 2007: Metabolic bone disease: what has changed in 30 years? Skeletal Radiol. 38(9):841-53, 2009
                                                                          6. Bardin T: Musculoskeletal manifestations of chronic renal failure. Curr Opin Rheumatol. 15(1):48-54, 2003
                                                                          7. Jevtic V: Imaging of renal osteodystrophy. Eur J Radiol. 46(2):85-95, 2003
                                                                          8. Paderni S et al: Vertebral localization of a brown tumor: description of a case and review of the literature. Chir Organi Mov. 88(1):83-91, 2003
                                                                          9. Spasovski GB et al: Spectrum of renal bone disease in end-stage renal failure patients not yet on dialysis. Nephrol Dial Transplant. 18(6):1159-66, 2003