Renal osteodystrophy (ROD): musculoskeletal manifestations of osteomalacia and 2° hyperparathyroidism (HPTH)
2° HPTH includes bone resorption, osteoporosis, soft tissue calcifications, bone deposition
Complications of dialysis often lumped into ROD: amyloidosis and destructive spondyloarthropathy
Chronic kidney disease-mineral bone disorder (CKD-MBD): newer term for syndrome of abnormalities of calcium, phosphorus, vitamin D, and parathyroid hormone (PTH) with associated bone changes and extraskeletal calcification caused by CKD
Neostosis: anachronistic term for bone production/deposition; not favored
IMAGING
General Features
Imaging Recommendations
Radiographic Findings
CT Findings
MR Findings
Nuclear Medicine Findings
Other Modality Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Microscopic Features
Laboratory Analysis
CLINICAL ISSUES
Presentation
Demographics
Selected References
Gulati V et al: Sclerotic bone lesions caused by non-infectious and non-neoplastic diseases: a review of the imaging and clinicopathologic findings. Skeletal Radiol. 50(5):847-69, 2021
Testini V et al: Metabolic bone diseases in the pediatric population. Semin Musculoskelet Radiol. 25(1):94-104, 2021
Usmani S et al: Update on imaging in chronic kidney disease-mineral and bone disorder: promising role of functional imaging. Skeletal Radiol. ePub, 2021
Alexander AJ et al: Imaging in chronic kidney disease-metabolic bone disease. Semin Dial. 30(4):361-8, 2017
Babayev R et al: Bone disorders in chronic kidney disease: an update in diagnosis and management. Semin Dial. 28(6):645-53, 2015
Degrassi F et al: Imaging of haemodialysis: renal and extrarenal findings. Insights Imaging. 6(3):309-21, 2015
Kazama JJ et al: Chronic kidney disease and bone metabolism. J Bone Miner Metab. 33(3):245-52, 2015
Abdel Razek AA: Computed tomography and magnetic resonance imaging of maxillofacial lesions in renal osteodystrophy. J Craniofac Surg. 25(4):1354-7, 2014
Rajapakse CS et al: Micro-MR imaging-based computational biomechanics demonstrates reduction in cortical and trabecular bone strength after renal transplantation. Radiology. 262(3):912-20, 2012
Sundaram M. Founders lecture 2007: Metabolic bone disease: what has changed in 30 years? Skeletal Radiol. 38(9):841-53, 2009
Kelly A et al: Musculoskeletal pain in dialysis-related amyloidosis. Can J Surg. 50(4):305-6, 2007
Slavotinek JP et al: Shoulder appearances at MR imaging in long-term dialysis recipients. Radiology. 217(2):539-43, 2000
Murphey MD et al: Musculoskeletal manifestations of chronic renal insufficiency. Radiographics. 13(2):357-79, 1993
Kurer MH et al: Musculoskeletal manifestations of amyloidosis. A review of 83 patients on haemodialysis for at least 10 years. J Bone Joint Surg Br. 73(2):271-6, 1991
Jensen PS et al: Early radiographic manifestations of secondary hyperparathyroidism associated with chronic renal disease. Radiology. 125(3):645-52, 1977
Greenfield GB: Roentgen appearance of bone and soft tissue changes in chronic renal disease. Am J Roentgenol Radium Ther Nucl Med. 116(4):749-57, 1972
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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
TERMINOLOGY
Definitions
Renal osteodystrophy (ROD): musculoskeletal manifestations of osteomalacia and 2° hyperparathyroidism (HPTH)
2° HPTH includes bone resorption, osteoporosis, soft tissue calcifications, bone deposition
Complications of dialysis often lumped into ROD: amyloidosis and destructive spondyloarthropathy
Chronic kidney disease-mineral bone disorder (CKD-MBD): newer term for syndrome of abnormalities of calcium, phosphorus, vitamin D, and parathyroid hormone (PTH) with associated bone changes and extraskeletal calcification caused by CKD
Neostosis: anachronistic term for bone production/deposition; not favored
IMAGING
General Features
Imaging Recommendations
Radiographic Findings
CT Findings
MR Findings
Nuclear Medicine Findings
Other Modality Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Microscopic Features
Laboratory Analysis
CLINICAL ISSUES
Presentation
Demographics
Selected References
Gulati V et al: Sclerotic bone lesions caused by non-infectious and non-neoplastic diseases: a review of the imaging and clinicopathologic findings. Skeletal Radiol. 50(5):847-69, 2021
Testini V et al: Metabolic bone diseases in the pediatric population. Semin Musculoskelet Radiol. 25(1):94-104, 2021
Usmani S et al: Update on imaging in chronic kidney disease-mineral and bone disorder: promising role of functional imaging. Skeletal Radiol. ePub, 2021
Alexander AJ et al: Imaging in chronic kidney disease-metabolic bone disease. Semin Dial. 30(4):361-8, 2017
Babayev R et al: Bone disorders in chronic kidney disease: an update in diagnosis and management. Semin Dial. 28(6):645-53, 2015
Degrassi F et al: Imaging of haemodialysis: renal and extrarenal findings. Insights Imaging. 6(3):309-21, 2015
Kazama JJ et al: Chronic kidney disease and bone metabolism. J Bone Miner Metab. 33(3):245-52, 2015
Abdel Razek AA: Computed tomography and magnetic resonance imaging of maxillofacial lesions in renal osteodystrophy. J Craniofac Surg. 25(4):1354-7, 2014
Rajapakse CS et al: Micro-MR imaging-based computational biomechanics demonstrates reduction in cortical and trabecular bone strength after renal transplantation. Radiology. 262(3):912-20, 2012
Sundaram M. Founders lecture 2007: Metabolic bone disease: what has changed in 30 years? Skeletal Radiol. 38(9):841-53, 2009
Kelly A et al: Musculoskeletal pain in dialysis-related amyloidosis. Can J Surg. 50(4):305-6, 2007
Slavotinek JP et al: Shoulder appearances at MR imaging in long-term dialysis recipients. Radiology. 217(2):539-43, 2000
Murphey MD et al: Musculoskeletal manifestations of chronic renal insufficiency. Radiographics. 13(2):357-79, 1993
Kurer MH et al: Musculoskeletal manifestations of amyloidosis. A review of 83 patients on haemodialysis for at least 10 years. J Bone Joint Surg Br. 73(2):271-6, 1991
Jensen PS et al: Early radiographic manifestations of secondary hyperparathyroidism associated with chronic renal disease. Radiology. 125(3):645-52, 1977
Greenfield GB: Roentgen appearance of bone and soft tissue changes in chronic renal disease. Am J Roentgenol Radium Ther Nucl Med. 116(4):749-57, 1972
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