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Respiratory Bronchiolitis-Interstitial Lung Disease (HRCT)
Kyung Soo Lee, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Abbreviations

                • Respiratory bronchiolitis-interstitial lung disease (RB-ILD)
              • Definitions

                • RB: Cellular bronchiolitis present in virtually all smokers, characterized by accumulation of pigmented macrophages in airways and alveoli
                • RB-ILD: Smoking-related ILD closely related to RB but with more severe histologic, imaging, and clinical features; RB causing symptoms and pulmonary function deficits
                • Spectrum of smoking-related ILD: RB, RB-ILD, and desquamative interstitial pneumonia (DIP)

              IMAGING

              • General Features

                • Radiographic Findings

                  • CT Findings

                    • Imaging Recommendations

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Microscopic Features

                            CLINICAL ISSUES

                            • Presentation

                              • Demographics

                                • Diagnosis

                                  • Natural History & Prognosis

                                    • Treatment

                                      DIAGNOSTIC CHECKLIST

                                      • Consider

                                        Selected References

                                        1. Sieminska A et al: Respiratory bronchiolitis-interstitial lung disease. Orphanet J Rare Dis. 9:106, 2014
                                        2. Travis WD et al: An official American Thoracic Society/European Respiratory Society statement: update of the international multidisciplinary classification of the idiopathic interstitial pneumonias. Am J Respir Crit Care Med. 188(6):733-48, 2013
                                        3. Attili AK et al: Smoking-related interstitial lung disease: radiologic-clinical-pathologic correlation. Radiographics. 28(5):1383-96; discussion 1396-8, 2008
                                        4. Nakanishi M et al: Changes in HRCT findings in patients with respiratory bronchiolitis-associated interstitial lung disease after smoking cessation. Eur Respir J. 29(3):453-61, 2007
                                        5. Portnoy J et al: Respiratory bronchiolitis-interstitial lung disease: long-term outcome. Chest. 131(3):664-71, 2007
                                        6. Fraig M et al: Respiratory bronchiolitis: a clinicopathologic study in current smokers, ex-smokers, and never-smokers. Am J Surg Pathol. 26(5):647-53, 2002
                                        7. Park JS et al: Respiratory bronchiolitis-associated interstitial lung disease: radiologic features with clinical and pathologic correlation. J Comput Assist Tomogr. 26(1):13-20, 2002
                                        Related Anatomy
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                                        Related Differential Diagnoses
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                                        References
                                        Tables

                                        Tables

                                        KEY FACTS

                                        • Terminology

                                          • Imaging

                                            • Top Differential Diagnoses

                                              • Pathology

                                                • Clinical Issues

                                                  • Diagnostic Checklist

                                                    TERMINOLOGY

                                                    • Abbreviations

                                                      • Respiratory bronchiolitis-interstitial lung disease (RB-ILD)
                                                    • Definitions

                                                      • RB: Cellular bronchiolitis present in virtually all smokers, characterized by accumulation of pigmented macrophages in airways and alveoli
                                                      • RB-ILD: Smoking-related ILD closely related to RB but with more severe histologic, imaging, and clinical features; RB causing symptoms and pulmonary function deficits
                                                      • Spectrum of smoking-related ILD: RB, RB-ILD, and desquamative interstitial pneumonia (DIP)

                                                    IMAGING

                                                    • General Features

                                                      • Radiographic Findings

                                                        • CT Findings

                                                          • Imaging Recommendations

                                                            DIFFERENTIAL DIAGNOSIS

                                                              PATHOLOGY

                                                              • General Features

                                                                • Microscopic Features

                                                                  CLINICAL ISSUES

                                                                  • Presentation

                                                                    • Demographics

                                                                      • Diagnosis

                                                                        • Natural History & Prognosis

                                                                          • Treatment

                                                                            DIAGNOSTIC CHECKLIST

                                                                            • Consider

                                                                              Selected References

                                                                              1. Sieminska A et al: Respiratory bronchiolitis-interstitial lung disease. Orphanet J Rare Dis. 9:106, 2014
                                                                              2. Travis WD et al: An official American Thoracic Society/European Respiratory Society statement: update of the international multidisciplinary classification of the idiopathic interstitial pneumonias. Am J Respir Crit Care Med. 188(6):733-48, 2013
                                                                              3. Attili AK et al: Smoking-related interstitial lung disease: radiologic-clinical-pathologic correlation. Radiographics. 28(5):1383-96; discussion 1396-8, 2008
                                                                              4. Nakanishi M et al: Changes in HRCT findings in patients with respiratory bronchiolitis-associated interstitial lung disease after smoking cessation. Eur Respir J. 29(3):453-61, 2007
                                                                              5. Portnoy J et al: Respiratory bronchiolitis-interstitial lung disease: long-term outcome. Chest. 131(3):664-71, 2007
                                                                              6. Fraig M et al: Respiratory bronchiolitis: a clinicopathologic study in current smokers, ex-smokers, and never-smokers. Am J Surg Pathol. 26(5):647-53, 2002
                                                                              7. Park JS et al: Respiratory bronchiolitis-associated interstitial lung disease: radiologic features with clinical and pathologic correlation. J Comput Assist Tomogr. 26(1):13-20, 2002