link
Bookmarks
Pediatrics
Diagnosis
Pediatric Neuroradiology
Head and Neck
Orbit, Nose, and Sinuses
Retinoblastoma
Retinoblastoma
Bernadette L. Koch, MD
To access 4,300 diagnoses written by the world's leading experts in radiology.Try it free - 15 days
0
14
4
9

KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Abbreviations

                • Retinoblastoma (RB)

              • Definitions

                • Malignant primary retinal neoplasm
                • Trilateral RB: Bilateral ocular tumors + midline intracranial neuroblastic tumor, typically pineal
                • Quadrilateral/tetralateral RB: Bilateral disease + pineal & suprasellar tumors
                • Retinocytoma: Rare benign variant with similar genetics

              IMAGING

              • General Features

                • CT Findings

                  • MR Findings

                    • Ultrasonographic Findings

                      • Imaging Recommendations

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Staging, Grading, & Classification

                              • Gross Pathologic & Surgical Features

                                • Microscopic Features

                                  CLINICAL ISSUES

                                  • Presentation

                                    • Demographics

                                      • Natural History & Prognosis

                                        • Treatment

                                          DIAGNOSTIC CHECKLIST

                                          • Consider

                                            • Image Interpretation Pearls

                                              Selected References

                                              1. Wyse E et al: A review of the literature for intra-arterial chemotherapy used to treat retinoblastoma. Pediatr Radiol. 46(9):1223-33, 2016
                                              2. Yousef YA et al: Intra-arterial chemotherapy for retinoblastoma: a systematic review. JAMA Ophthalmol. ePub, 2016
                                              3. Abramson DH et al: Treatment of retinoblastoma in 2015: agreement and disagreement. JAMA Ophthalmol. 133(11):1341-7, 2015
                                              4. Delhiwala KS et al: Retinoblastoma: An update. Semin Diagn Pathol. 33(3):133-40, 2015
                                              5. Learned KO et al: Imaging of the postoperative orbit. Neuroimaging Clin N Am. 25(3):457-76, 2015
                                              6. Sirin S et al: High-resolution MRI using orbit surface coils for the evaluation of metastatic risk factors in 143 children with retinoblastoma: Part 1: MRI vs. histopathology. Neuroradiology. 57(8):805-14, 2015
                                              7. Barnwell JD et al: MR imaging of progressive enhancement of a bioceramic orbital prosthesis: an indicator of fibrovascular invasion. AJNR Am J Neuroradiol. 32(1):E8-9, 2011
                                              8. de Graaf P et al: Contrast-enhancement of the anterior eye segment in patients with retinoblastoma: correlation between clinical, MR imaging, and histopathologic findings. AJNR Am J Neuroradiol. 31(2):237-45, 2010
                                              9. Dunkel IJ et al: Trilateral retinoblastoma: potentially curable with intensive chemotherapy. Pediatr Blood Cancer. 54(3):384-7, 2010
                                              10. Mallipatna AC et al: Management and outcome of unilateral retinoblastoma. J AAPOS. 13(6):546-50, 2009
                                              11. Wilson MW et al: Lack of correlation between the histologic and magnetic resonance imaging results of optic nerve involvement in eyes primarily enucleated for retinoblastoma. Ophthalmology. 116(8):1558-63, 2009
                                              12. Yu CL et al: Cause-specific mortality in long-term survivors of retinoblastoma. J Natl Cancer Inst. 101(8):581-91, 2009
                                              13. de Graaf P et al: Eye size in retinoblastoma: MR imaging measurements in normal and affected eyes. Radiology. 244(1):273-80, 2007
                                              14. Murphree L: Staging and grouping of retinoblastoma. In Singh A et al: Clinical Ophthalmic Oncology. Philadelphia: Saunders Elsevier. 422-7, 2007
                                              15. Aerts I et al: Retinoblastoma. Orphanet J Rare Dis. 1:31, 2006
                                              16. Shields CL et al: The International Classification of Retinoblastoma predicts chemoreduction success. Ophthalmology. 113(12):2276-80, 2006
                                              17. de Graaf P et al: Retinoblastoma: MR imaging parameters in detection of tumor extent. Radiology. 235(1):197-207, 2005
                                              18. Galluzzi P et al: Retinoblastoma: Abnormal gadolinium enhancement of anterior segment of eyes at MR imaging with clinical and histopathologic correlation. Radiology. 228(3):683-90, 2003
                                              19. Tateishi U et al: CT and MRI features of recurrent tumors and second primary neoplasms in pediatric patients with retinoblastoma. AJR Am J Roentgenol. 181(3):879-84, 2003
                                              20. Brisse HJ et al: Sonographic, CT, and MR imaging findings in diffuse infiltrative retinoblastoma: report of two cases with histologic comparison. AJNR Am J Neuroradiol. 22(3):499-504, 2001
                                              Related Anatomy
                                              Loading...
                                              Related Differential Diagnoses
                                              Loading...
                                              References
                                              Tables

                                              Tables

                                              KEY FACTS

                                              • Terminology

                                                • Imaging

                                                  • Top Differential Diagnoses

                                                    • Pathology

                                                      • Clinical Issues

                                                        • Diagnostic Checklist

                                                          TERMINOLOGY

                                                          • Abbreviations

                                                            • Retinoblastoma (RB)

                                                          • Definitions

                                                            • Malignant primary retinal neoplasm
                                                            • Trilateral RB: Bilateral ocular tumors + midline intracranial neuroblastic tumor, typically pineal
                                                            • Quadrilateral/tetralateral RB: Bilateral disease + pineal & suprasellar tumors
                                                            • Retinocytoma: Rare benign variant with similar genetics

                                                          IMAGING

                                                          • General Features

                                                            • CT Findings

                                                              • MR Findings

                                                                • Ultrasonographic Findings

                                                                  • Imaging Recommendations

                                                                    DIFFERENTIAL DIAGNOSIS

                                                                      PATHOLOGY

                                                                      • General Features

                                                                        • Staging, Grading, & Classification

                                                                          • Gross Pathologic & Surgical Features

                                                                            • Microscopic Features

                                                                              CLINICAL ISSUES

                                                                              • Presentation

                                                                                • Demographics

                                                                                  • Natural History & Prognosis

                                                                                    • Treatment

                                                                                      DIAGNOSTIC CHECKLIST

                                                                                      • Consider

                                                                                        • Image Interpretation Pearls

                                                                                          Selected References

                                                                                          1. Wyse E et al: A review of the literature for intra-arterial chemotherapy used to treat retinoblastoma. Pediatr Radiol. 46(9):1223-33, 2016
                                                                                          2. Yousef YA et al: Intra-arterial chemotherapy for retinoblastoma: a systematic review. JAMA Ophthalmol. ePub, 2016
                                                                                          3. Abramson DH et al: Treatment of retinoblastoma in 2015: agreement and disagreement. JAMA Ophthalmol. 133(11):1341-7, 2015
                                                                                          4. Delhiwala KS et al: Retinoblastoma: An update. Semin Diagn Pathol. 33(3):133-40, 2015
                                                                                          5. Learned KO et al: Imaging of the postoperative orbit. Neuroimaging Clin N Am. 25(3):457-76, 2015
                                                                                          6. Sirin S et al: High-resolution MRI using orbit surface coils for the evaluation of metastatic risk factors in 143 children with retinoblastoma: Part 1: MRI vs. histopathology. Neuroradiology. 57(8):805-14, 2015
                                                                                          7. Barnwell JD et al: MR imaging of progressive enhancement of a bioceramic orbital prosthesis: an indicator of fibrovascular invasion. AJNR Am J Neuroradiol. 32(1):E8-9, 2011
                                                                                          8. de Graaf P et al: Contrast-enhancement of the anterior eye segment in patients with retinoblastoma: correlation between clinical, MR imaging, and histopathologic findings. AJNR Am J Neuroradiol. 31(2):237-45, 2010
                                                                                          9. Dunkel IJ et al: Trilateral retinoblastoma: potentially curable with intensive chemotherapy. Pediatr Blood Cancer. 54(3):384-7, 2010
                                                                                          10. Mallipatna AC et al: Management and outcome of unilateral retinoblastoma. J AAPOS. 13(6):546-50, 2009
                                                                                          11. Wilson MW et al: Lack of correlation between the histologic and magnetic resonance imaging results of optic nerve involvement in eyes primarily enucleated for retinoblastoma. Ophthalmology. 116(8):1558-63, 2009
                                                                                          12. Yu CL et al: Cause-specific mortality in long-term survivors of retinoblastoma. J Natl Cancer Inst. 101(8):581-91, 2009
                                                                                          13. de Graaf P et al: Eye size in retinoblastoma: MR imaging measurements in normal and affected eyes. Radiology. 244(1):273-80, 2007
                                                                                          14. Murphree L: Staging and grouping of retinoblastoma. In Singh A et al: Clinical Ophthalmic Oncology. Philadelphia: Saunders Elsevier. 422-7, 2007
                                                                                          15. Aerts I et al: Retinoblastoma. Orphanet J Rare Dis. 1:31, 2006
                                                                                          16. Shields CL et al: The International Classification of Retinoblastoma predicts chemoreduction success. Ophthalmology. 113(12):2276-80, 2006
                                                                                          17. de Graaf P et al: Retinoblastoma: MR imaging parameters in detection of tumor extent. Radiology. 235(1):197-207, 2005
                                                                                          18. Galluzzi P et al: Retinoblastoma: Abnormal gadolinium enhancement of anterior segment of eyes at MR imaging with clinical and histopathologic correlation. Radiology. 228(3):683-90, 2003
                                                                                          19. Tateishi U et al: CT and MRI features of recurrent tumors and second primary neoplasms in pediatric patients with retinoblastoma. AJR Am J Roentgenol. 181(3):879-84, 2003
                                                                                          20. Brisse HJ et al: Sonographic, CT, and MR imaging findings in diffuse infiltrative retinoblastoma: report of two cases with histologic comparison. AJNR Am J Neuroradiol. 22(3):499-504, 2001