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Retroperitoneal Sarcoma
Alice Fung, MD
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KEY FACTS

  • Imaging

    • Top Differential Diagnoses

      • Clinical Issues

        • Diagnostic Checklist

          TERMINOLOGY

          • Definitions

            • Malignant primary retroperitoneal (RP) sarcomas are of mesodermal origin and include heterogeneous group of tumors
            • Most common adult RP sarcomas are discussed here

          IMAGING

          • General Features

            • CT Findings

              • MR Findings

                • Ultrasonographic Findings

                  • Image-Guided Biopsy

                    • Nuclear Medicine Findings

                      • Imaging Recommendations

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Gross Pathologic & Surgical Features

                              • Microscopic Features

                                CLINICAL ISSUES

                                • Presentation

                                  • Demographics

                                    • Natural History & Prognosis

                                      • Treatment

                                        DIAGNOSTIC CHECKLIST

                                        • Consider

                                          • Image Interpretation Pearls

                                            Selected References

                                            1. Czeyda-Pommersheim F et al: Diagnostic approach to primary retroperitoneal pathologies: what the radiologist needs to know. Abdom Radiol (NY). 46(3):1062-81, 2020
                                            2. Marko J et al: Retroperitoneal leiomyosarcoma from the Radiologic Pathology Archives. Radiographics. 38(5):1403-20, 2018
                                            3. Levy AD et al: Soft-tissue sarcomas of the abdomen and pelvis: radiologic-pathologic features, part 1-common sarcomas: from the Radiologic Pathology Archives. Radiographics. 37(2):462-83, 2017
                                            4. Levy AD et al: Soft-tissue sarcomas of the abdomen and pelvis: radiologic-pathologic features, part 2-uncommon sarcomas. Radiographics. 37(3):797-812, 2017
                                            5. Tseng WW et al: Locoregional disease patterns in well-differentiated and dedifferentiated retroperitoneal liposarcoma: implications for the extent of resection? Ann Surg Oncol. 21(7):2136-43, 2014
                                            6. Eberhardt SC et al: Oncology imaging in the abdomen and pelvis: where cancer hides. Abdom Imaging. 38(4):647-71, 2013
                                            7. Hekimoglu K: Giant retroperitoneal liposarcomas: diagnostic approach with multidetector computed tomography and magnetic resonance imaging. JBR-BTR. 96(6):375-7, 2013
                                            8. Osman S et al: A comprehensive review of the retroperitoneal anatomy, neoplasms, and pattern of disease spread. Curr Probl Diagn Radiol. 42(5):191-208, 2013
                                            9. Shiraev T et al: Retroperitoneal sarcomas: a review of disease spectrum, radiological features, characterisation and management. J Med Imaging Radiat Oncol. 57(6):687-700, 2013
                                            10. Goenka AH et al: Imaging of the retroperitoneum. Radiol Clin North Am. 50(2):333-55, vii, 2012
                                            11. Heller MT et al: Neoplastic and proliferative disorders of the perinephric space. Clin Radiol. 67(11):e31-41, 2012
                                            12. Kumarasamy NA et al: Retroperitoneal sarcomas. Semin Ultrasound CT MR. 32(5):422-32, 2011
                                            13. Schwarzbach MH et al: Current concepts in the management of retroperitoneal soft tissue sarcoma. Recent Results Cancer Res. 179:301-19, 2009
                                            14. Hosaka A et al: Retroperitoneal mixed-type liposarcoma showing features of four different subtypes. Am Surg. 74(12):1202-5, 2008
                                            15. Bellin MF et al: Evaluation of retroperitoneal and pelvic lymph node metastases with MRI and MR lymphangiography. Abdom Imaging. 28(2):155-63, 2003
                                            16. Nishino M et al: Primary retroperitoneal neoplasms: CT and MR imaging findings with anatomic and pathologic diagnostic clues. Radiographics. 23(1):45-57, 2003
                                            17. Tateishi U et al: Primary dedifferentiated liposarcoma of the retroperitoneum. Prognostic significance of computed tomography and magnetic resonance imaging features. J Comput Assist Tomogr. 27(5):799-804, 2003
                                            18. Grubnic S et al: MR evaluation of normal retroperitoneal and pelvic lymph nodes. Clin Radiol. 57(3):193-200; discussion 201-4, 2002
                                            19. Israel GM et al: CT differentiation of large exophytic renal angiomyolipomas and perirenal liposarcomas. AJR Am J Roentgenol. 179(3):769-73, 2002
                                            Related Anatomy
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                                            Related Differential Diagnoses
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                                            References
                                            Tables

                                            Tables

                                            KEY FACTS

                                            • Imaging

                                              • Top Differential Diagnoses

                                                • Clinical Issues

                                                  • Diagnostic Checklist

                                                    TERMINOLOGY

                                                    • Definitions

                                                      • Malignant primary retroperitoneal (RP) sarcomas are of mesodermal origin and include heterogeneous group of tumors
                                                      • Most common adult RP sarcomas are discussed here

                                                    IMAGING

                                                    • General Features

                                                      • CT Findings

                                                        • MR Findings

                                                          • Ultrasonographic Findings

                                                            • Image-Guided Biopsy

                                                              • Nuclear Medicine Findings

                                                                • Imaging Recommendations

                                                                  DIFFERENTIAL DIAGNOSIS

                                                                    PATHOLOGY

                                                                    • General Features

                                                                      • Gross Pathologic & Surgical Features

                                                                        • Microscopic Features

                                                                          CLINICAL ISSUES

                                                                          • Presentation

                                                                            • Demographics

                                                                              • Natural History & Prognosis

                                                                                • Treatment

                                                                                  DIAGNOSTIC CHECKLIST

                                                                                  • Consider

                                                                                    • Image Interpretation Pearls

                                                                                      Selected References

                                                                                      1. Czeyda-Pommersheim F et al: Diagnostic approach to primary retroperitoneal pathologies: what the radiologist needs to know. Abdom Radiol (NY). 46(3):1062-81, 2020
                                                                                      2. Marko J et al: Retroperitoneal leiomyosarcoma from the Radiologic Pathology Archives. Radiographics. 38(5):1403-20, 2018
                                                                                      3. Levy AD et al: Soft-tissue sarcomas of the abdomen and pelvis: radiologic-pathologic features, part 1-common sarcomas: from the Radiologic Pathology Archives. Radiographics. 37(2):462-83, 2017
                                                                                      4. Levy AD et al: Soft-tissue sarcomas of the abdomen and pelvis: radiologic-pathologic features, part 2-uncommon sarcomas. Radiographics. 37(3):797-812, 2017
                                                                                      5. Tseng WW et al: Locoregional disease patterns in well-differentiated and dedifferentiated retroperitoneal liposarcoma: implications for the extent of resection? Ann Surg Oncol. 21(7):2136-43, 2014
                                                                                      6. Eberhardt SC et al: Oncology imaging in the abdomen and pelvis: where cancer hides. Abdom Imaging. 38(4):647-71, 2013
                                                                                      7. Hekimoglu K: Giant retroperitoneal liposarcomas: diagnostic approach with multidetector computed tomography and magnetic resonance imaging. JBR-BTR. 96(6):375-7, 2013
                                                                                      8. Osman S et al: A comprehensive review of the retroperitoneal anatomy, neoplasms, and pattern of disease spread. Curr Probl Diagn Radiol. 42(5):191-208, 2013
                                                                                      9. Shiraev T et al: Retroperitoneal sarcomas: a review of disease spectrum, radiological features, characterisation and management. J Med Imaging Radiat Oncol. 57(6):687-700, 2013
                                                                                      10. Goenka AH et al: Imaging of the retroperitoneum. Radiol Clin North Am. 50(2):333-55, vii, 2012
                                                                                      11. Heller MT et al: Neoplastic and proliferative disorders of the perinephric space. Clin Radiol. 67(11):e31-41, 2012
                                                                                      12. Kumarasamy NA et al: Retroperitoneal sarcomas. Semin Ultrasound CT MR. 32(5):422-32, 2011
                                                                                      13. Schwarzbach MH et al: Current concepts in the management of retroperitoneal soft tissue sarcoma. Recent Results Cancer Res. 179:301-19, 2009
                                                                                      14. Hosaka A et al: Retroperitoneal mixed-type liposarcoma showing features of four different subtypes. Am Surg. 74(12):1202-5, 2008
                                                                                      15. Bellin MF et al: Evaluation of retroperitoneal and pelvic lymph node metastases with MRI and MR lymphangiography. Abdom Imaging. 28(2):155-63, 2003
                                                                                      16. Nishino M et al: Primary retroperitoneal neoplasms: CT and MR imaging findings with anatomic and pathologic diagnostic clues. Radiographics. 23(1):45-57, 2003
                                                                                      17. Tateishi U et al: Primary dedifferentiated liposarcoma of the retroperitoneum. Prognostic significance of computed tomography and magnetic resonance imaging features. J Comput Assist Tomogr. 27(5):799-804, 2003
                                                                                      18. Grubnic S et al: MR evaluation of normal retroperitoneal and pelvic lymph nodes. Clin Radiol. 57(3):193-200; discussion 201-4, 2002
                                                                                      19. Israel GM et al: CT differentiation of large exophytic renal angiomyolipomas and perirenal liposarcomas. AJR Am J Roentgenol. 179(3):769-73, 2002