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Retroperitoneal Sarcoma
Matthew T. Heller, MD, FSAR; Michael P. Federle, MD, FACR
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KEY FACTS

  • Imaging

    • Top Differential Diagnoses

      • Clinical Issues

        TERMINOLOGY

        • Definitions

          • Malignant primary retroperitoneal (RP) tumor arising from various elements of primitive mesenchyme, urogenital ridge, or embryonic remnants

        IMAGING

        • General Features

          • Radiographic Findings

            • CT Findings

              • MR Findings

                • Ultrasonographic Findings

                  • Angiographic Findings

                    • Imaging Recommendations

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Gross Pathologic & Surgical Features

                            • Microscopic Features

                              CLINICAL ISSUES

                              • Presentation

                                • Demographics

                                  • Natural History & Prognosis

                                    • Treatment

                                      DIAGNOSTIC CHECKLIST

                                      • Consider

                                        • Image Interpretation Pearls

                                          Selected References

                                          1. Tseng WW et al: Locoregional disease patterns in well-differentiated and dedifferentiated retroperitoneal liposarcoma: implications for the extent of resection? Ann Surg Oncol. 21(7):2136-43, 2014
                                          2. Eberhardt SC et al: Oncology imaging in the abdomen and pelvis: where cancer hides. Abdom Imaging. 38(4):647-71, 2013
                                          3. Hekimoglu K: Giant retroperitoneal liposarcomas: diagnostic approach with multidetector computed tomography and magnetic resonance imaging. JBR-BTR. 96(6):375-7, 2013
                                          4. Osman S et al: A comprehensive review of the retroperitoneal anatomy, neoplasms, and pattern of disease spread. Curr Probl Diagn Radiol. 42(5):191-208, 2013
                                          5. Shiraev T et al: Retroperitoneal sarcomas: a review of disease spectrum, radiological features, characterisation and management. J Med Imaging Radiat Oncol. 57(6):687-700, 2013
                                          6. Goenka AH et al: Imaging of the retroperitoneum. Radiol Clin North Am. 50(2):333-55, vii, 2012
                                          7. Heller MT et al: Neoplastic and proliferative disorders of the perinephric space. Clin Radiol. 67(11):e31-41, 2012
                                          8. Kumarasamy NA et al: Retroperitoneal sarcomas. Semin Ultrasound CT MR. 32(5):422-32, 2011
                                          9. Schwarzbach MH et al: Current concepts in the management of retroperitoneal soft tissue sarcoma. Recent Results Cancer Res. 179:301-19, 2009
                                          10. Hosaka A et al: Retroperitoneal mixed-type liposarcoma showing features of four different subtypes. Am Surg. 74(12):1202-5, 2008
                                          11. Bellin MF et al: Evaluation of retroperitoneal and pelvic lymph node metastases with MRI and MR lymphangiography. Abdom Imaging. 28(2):155-63, 2003
                                          12. Nishino M et al: Primary retroperitoneal neoplasms: CT and MR imaging findings with anatomic and pathologic diagnostic clues. Radiographics. 23(1):45-57, 2003
                                          13. Tateishi U et al: Primary dedifferentiated liposarcoma of the retroperitoneum. Prognostic significance of computed tomography and magnetic resonance imaging features. J Comput Assist Tomogr. 27(5):799-804, 2003
                                          14. Grubnic S et al: MR evaluation of normal retroperitoneal and pelvic lymph nodes. Clin Radiol. 57(3):193-200; discussion 201-4, 2002
                                          15. Israel GM et al: CT differentiation of large exophytic renal angiomyolipomas and perirenal liposarcomas. AJR Am J Roentgenol. 179(3):769-73, 2002
                                          Related Anatomy
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                                          Related Differential Diagnoses
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                                          References
                                          Tables

                                          Tables

                                          KEY FACTS

                                          • Imaging

                                            • Top Differential Diagnoses

                                              • Clinical Issues

                                                TERMINOLOGY

                                                • Definitions

                                                  • Malignant primary retroperitoneal (RP) tumor arising from various elements of primitive mesenchyme, urogenital ridge, or embryonic remnants

                                                IMAGING

                                                • General Features

                                                  • Radiographic Findings

                                                    • CT Findings

                                                      • MR Findings

                                                        • Ultrasonographic Findings

                                                          • Angiographic Findings

                                                            • Imaging Recommendations

                                                              DIFFERENTIAL DIAGNOSIS

                                                                PATHOLOGY

                                                                • General Features

                                                                  • Gross Pathologic & Surgical Features

                                                                    • Microscopic Features

                                                                      CLINICAL ISSUES

                                                                      • Presentation

                                                                        • Demographics

                                                                          • Natural History & Prognosis

                                                                            • Treatment

                                                                              DIAGNOSTIC CHECKLIST

                                                                              • Consider

                                                                                • Image Interpretation Pearls

                                                                                  Selected References

                                                                                  1. Tseng WW et al: Locoregional disease patterns in well-differentiated and dedifferentiated retroperitoneal liposarcoma: implications for the extent of resection? Ann Surg Oncol. 21(7):2136-43, 2014
                                                                                  2. Eberhardt SC et al: Oncology imaging in the abdomen and pelvis: where cancer hides. Abdom Imaging. 38(4):647-71, 2013
                                                                                  3. Hekimoglu K: Giant retroperitoneal liposarcomas: diagnostic approach with multidetector computed tomography and magnetic resonance imaging. JBR-BTR. 96(6):375-7, 2013
                                                                                  4. Osman S et al: A comprehensive review of the retroperitoneal anatomy, neoplasms, and pattern of disease spread. Curr Probl Diagn Radiol. 42(5):191-208, 2013
                                                                                  5. Shiraev T et al: Retroperitoneal sarcomas: a review of disease spectrum, radiological features, characterisation and management. J Med Imaging Radiat Oncol. 57(6):687-700, 2013
                                                                                  6. Goenka AH et al: Imaging of the retroperitoneum. Radiol Clin North Am. 50(2):333-55, vii, 2012
                                                                                  7. Heller MT et al: Neoplastic and proliferative disorders of the perinephric space. Clin Radiol. 67(11):e31-41, 2012
                                                                                  8. Kumarasamy NA et al: Retroperitoneal sarcomas. Semin Ultrasound CT MR. 32(5):422-32, 2011
                                                                                  9. Schwarzbach MH et al: Current concepts in the management of retroperitoneal soft tissue sarcoma. Recent Results Cancer Res. 179:301-19, 2009
                                                                                  10. Hosaka A et al: Retroperitoneal mixed-type liposarcoma showing features of four different subtypes. Am Surg. 74(12):1202-5, 2008
                                                                                  11. Bellin MF et al: Evaluation of retroperitoneal and pelvic lymph node metastases with MRI and MR lymphangiography. Abdom Imaging. 28(2):155-63, 2003
                                                                                  12. Nishino M et al: Primary retroperitoneal neoplasms: CT and MR imaging findings with anatomic and pathologic diagnostic clues. Radiographics. 23(1):45-57, 2003
                                                                                  13. Tateishi U et al: Primary dedifferentiated liposarcoma of the retroperitoneum. Prognostic significance of computed tomography and magnetic resonance imaging features. J Comput Assist Tomogr. 27(5):799-804, 2003
                                                                                  14. Grubnic S et al: MR evaluation of normal retroperitoneal and pelvic lymph nodes. Clin Radiol. 57(3):193-200; discussion 201-4, 2002
                                                                                  15. Israel GM et al: CT differentiation of large exophytic renal angiomyolipomas and perirenal liposarcomas. AJR Am J Roentgenol. 179(3):769-73, 2002