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Chest
Differential Diagnosis
Lungs and Airspaces
Modality-Specific Imaging Findings: Computed Tomography
Reversed Halo Sign
Reversed Halo Sign
Santiago Martínez-Jiménez, MD
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DIFFERENTIAL DIAGNOSIS

    ESSENTIAL INFORMATION

    • Key Differential Diagnosis Issues

      • Helpful Clues for Common Diagnoses

        • Helpful Clues for Less Common Diagnoses

          • Helpful Clues for Rare Diagnoses

            Selected References

            1. Mançano AD et al: Incidence and morphological characteristics of the reversed halo sign in patients with acute pulmonary embolism and pulmonary infarction undergoing computed tomography angiography of the pulmonary arteries. J Bras Pneumol. 45(1):e20170438, 2019
            2. Thomas R et al: Significance of the reverse halo sign in immunocompromised patients. AJR Am J Roentgenol. 1-6, 2019
            3. Marchiori E et al: Morphological characteristics of the reversed halo sign that may strongly suggest pulmonary infarction. Clin Radiol. 73(5):503.e7-503.e13, 2018
            4. Mittal S et al: Thoracic imaging features of Legionnaire's disease. Infect Dis Clin North Am. 31(1):43-54, 2017
            5. Raju S et al: Chest CT signs in pulmonary disease: a pictorial review. Chest. 151(6):1356-74, 2017
            6. Rea G et al: The reversed halo sign: also think about chronic eosinophilic pneumonia. J Bras Pneumol. 43(4):322-3, 2017
            7. Zhan X et al: Reversed halo sign: presents in different pulmonary diseases. PLoS One. 10(6):e0128153, 2015
            8. Juan YH et al: Reverse halo sign in pulmonary mucormyosis. QJM. 107(9):777-8, 2014
            9. Stewart JI et al: Reverse halo sign on chest imaging in a renal transplant recipient. Transpl Infect Dis. 16(1):115-8, 2014
            10. Walsh S et al: Importance of the reversed halo sign for the diagnosis of angioinvasive pulmonary aspergillosis. Respir Med. 108(8):1240, 2014
            11. Madan K et al: Reverse halo sign. Lung India. 30(1):72-3, 2013
            12. Busca A et al: The reversed halo sign as the initial radiographic sign of pulmonary zygomycosis. Infection. 40(1):77-80, 2012
            13. Godoy MC et al: The reversed halo sign: update and differential diagnosis. Br J Radiol. 85(1017):1226-35, 2012
            14. Marchiori E et al: Reversed halo sign in invasive fungal infections: criteria for differentiation from organizing pneumonia. Chest. 142(6):1469-1473, 2012
            15. Marchiori E et al: Reversed halo sign: high-resolution CT scan findings in 79 patients. Chest. 141(5):1260-1266, 2012
            16. Marchiori E et al: Reversed halo sign on computed tomography: state-of-the-art review. Lung. 190(4):389-94, 2012
            17. Martinez F et al: Common and uncommon manifestations of Wegener granulomatosis at chest CT: radiologic-pathologic correlation. Radiographics. 32(1):51-69, 2012
            18. Algın O et al: Signs in chest imaging. Diagn Interv Radiol. 17(1):18-29, 2011
            19. Georgiadou SP et al: The diagnostic value of halo and reversed halo signs for invasive mold infections in compromised hosts. Clin Infect Dis. 52(9):1144-55, 2011
            20. Marchiori E et al: Atypical distribution of small nodules on high resolution CT studies: patterns and differentials. Respir Med. 105(9):1263-7, 2011
            21. Marchiori E et al: Reversed halo sign in active pulmonary tuberculosis: criteria for differentiation from cryptogenic organizing pneumonia. AJR Am J Roentgenol. 197(6):1324-7, 2011
            22. Marchiori E et al: Pulmonary tuberculosis associated with the reversed halo sign on high-resolution CT. Br J Radiol. 83(987):e58-60, 2010
            23. Kwon WJ et al: Computed tomographic features of pulmonary septic emboli: comparison of causative microorganisms. J Comput Assist Tomogr. 31(3):390-4, 2007
            24. Revel MP et al: Is It possible to recognize pulmonary infarction on multisection CT images? Radiology. 244(3):875-82, 2007
            25. Kim SJ et al: Reversed halo sign on high-resolution CT of cryptogenic organizing pneumonia: diagnostic implications. AJR Am J Roentgenol. 180(5):1251-4, 2003
            26. Lee JS et al: Lymphomatoid granulomatosis: radiologic features and pathologic correlations. AJR Am J Roentgenol. 175(5):1335-9, 2000
            Related Anatomy
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            References
            Tables

            Tables

            DIFFERENTIAL DIAGNOSIS

              ESSENTIAL INFORMATION

              • Key Differential Diagnosis Issues

                • Helpful Clues for Common Diagnoses

                  • Helpful Clues for Less Common Diagnoses

                    • Helpful Clues for Rare Diagnoses

                      Selected References

                      1. Mançano AD et al: Incidence and morphological characteristics of the reversed halo sign in patients with acute pulmonary embolism and pulmonary infarction undergoing computed tomography angiography of the pulmonary arteries. J Bras Pneumol. 45(1):e20170438, 2019
                      2. Thomas R et al: Significance of the reverse halo sign in immunocompromised patients. AJR Am J Roentgenol. 1-6, 2019
                      3. Marchiori E et al: Morphological characteristics of the reversed halo sign that may strongly suggest pulmonary infarction. Clin Radiol. 73(5):503.e7-503.e13, 2018
                      4. Mittal S et al: Thoracic imaging features of Legionnaire's disease. Infect Dis Clin North Am. 31(1):43-54, 2017
                      5. Raju S et al: Chest CT signs in pulmonary disease: a pictorial review. Chest. 151(6):1356-74, 2017
                      6. Rea G et al: The reversed halo sign: also think about chronic eosinophilic pneumonia. J Bras Pneumol. 43(4):322-3, 2017
                      7. Zhan X et al: Reversed halo sign: presents in different pulmonary diseases. PLoS One. 10(6):e0128153, 2015
                      8. Juan YH et al: Reverse halo sign in pulmonary mucormyosis. QJM. 107(9):777-8, 2014
                      9. Stewart JI et al: Reverse halo sign on chest imaging in a renal transplant recipient. Transpl Infect Dis. 16(1):115-8, 2014
                      10. Walsh S et al: Importance of the reversed halo sign for the diagnosis of angioinvasive pulmonary aspergillosis. Respir Med. 108(8):1240, 2014
                      11. Madan K et al: Reverse halo sign. Lung India. 30(1):72-3, 2013
                      12. Busca A et al: The reversed halo sign as the initial radiographic sign of pulmonary zygomycosis. Infection. 40(1):77-80, 2012
                      13. Godoy MC et al: The reversed halo sign: update and differential diagnosis. Br J Radiol. 85(1017):1226-35, 2012
                      14. Marchiori E et al: Reversed halo sign in invasive fungal infections: criteria for differentiation from organizing pneumonia. Chest. 142(6):1469-1473, 2012
                      15. Marchiori E et al: Reversed halo sign: high-resolution CT scan findings in 79 patients. Chest. 141(5):1260-1266, 2012
                      16. Marchiori E et al: Reversed halo sign on computed tomography: state-of-the-art review. Lung. 190(4):389-94, 2012
                      17. Martinez F et al: Common and uncommon manifestations of Wegener granulomatosis at chest CT: radiologic-pathologic correlation. Radiographics. 32(1):51-69, 2012
                      18. Algın O et al: Signs in chest imaging. Diagn Interv Radiol. 17(1):18-29, 2011
                      19. Georgiadou SP et al: The diagnostic value of halo and reversed halo signs for invasive mold infections in compromised hosts. Clin Infect Dis. 52(9):1144-55, 2011
                      20. Marchiori E et al: Atypical distribution of small nodules on high resolution CT studies: patterns and differentials. Respir Med. 105(9):1263-7, 2011
                      21. Marchiori E et al: Reversed halo sign in active pulmonary tuberculosis: criteria for differentiation from cryptogenic organizing pneumonia. AJR Am J Roentgenol. 197(6):1324-7, 2011
                      22. Marchiori E et al: Pulmonary tuberculosis associated with the reversed halo sign on high-resolution CT. Br J Radiol. 83(987):e58-60, 2010
                      23. Kwon WJ et al: Computed tomographic features of pulmonary septic emboli: comparison of causative microorganisms. J Comput Assist Tomogr. 31(3):390-4, 2007
                      24. Revel MP et al: Is It possible to recognize pulmonary infarction on multisection CT images? Radiology. 244(3):875-82, 2007
                      25. Kim SJ et al: Reversed halo sign on high-resolution CT of cryptogenic organizing pneumonia: diagnostic implications. AJR Am J Roentgenol. 180(5):1251-4, 2003
                      26. Lee JS et al: Lymphomatoid granulomatosis: radiologic features and pathologic correlations. AJR Am J Roentgenol. 175(5):1335-9, 2000
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