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Reversible Cerebral Vasoconstriction Syndrome
Karen L. Salzman, MD; Perry P. Ng, MBBS (Hons), FRANZCR
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KEY FACTS

  • Terminology

    • Imaging

      • Pathology

        • Clinical Issues

          TERMINOLOGY

          • Abbreviations

            • Reversible cerebral vasoconstriction syndrome (RCVS)
          • Synonyms

            • Call-Fleming syndrome
          • Definitions

            • Group of disorders characterized by
              • Reversible, multifocal cerebral artery vasoconstriction
              • Severe headaches (HA) ± focal neurological deficits

          IMAGING

          • General Features

            • CT Findings

              • MR Findings

                • Ultrasonographic Findings

                  • Angiographic Findings

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • General Features

                        CLINICAL ISSUES

                        • Presentation

                          • Natural History & Prognosis

                            • Treatment

                              DIAGNOSTIC CHECKLIST

                              • Consider

                                • Image Interpretation Pearls

                                  Selected References

                                  1. Kass-Hout T et al: A novel approach to diagnose reversible cerebral vasoconstriction syndrome: a case series. J Stroke Cerebrovasc Dis. 24(1):e31-7, 2015
                                  2. Agarwal R et al: Posterior reversible encephalopathy and cerebral vasoconstriction in a patient with hemolytic uremic syndrome. Pediatr Neurol. 50(5):518-21, 2014
                                  3. Calic Z et al: The Reversible Cerebral Vasoconstriction Syndrome. Intern Med J. ePub, 2014
                                  4. Grooters GS et al: How often is thunderclap headache caused by the reversible cerebral vasoconstriction syndrome? Headache. 54(4):732-5, 2014
                                  5. Katz BS et al: Clinical worsening in reversible cerebral vasoconstriction syndrome. JAMA Neurol. 71(1):68-73, 2014
                                  6. Wolff V et al: Ischaemic Strokes with Reversible Vasoconstriction and without Thunderclap Headache: A Variant of the Reversible Cerebral Vasoconstriction Syndrome? Cerebrovasc Dis. 39(1):31-38, 2014
                                  7. Muehlschlegel S et al: Differentiating reversible cerebral vasoconstriction syndrome with subarachnoid hemorrhage from other causes of subarachnoid hemorrhage. JAMA Neurol. 70(10):1254-60, 2013
                                  8. Marder CP et al: Multimodal imaging of reversible cerebral vasoconstriction syndrome: a series of 6 cases. AJNR Am J Neuroradiol. 33(7):1403-11, 2012
                                  9. Ducros A et al: The clinical and radiological spectrum of reversible cerebral vasoconstriction syndrome. A prospective series of 67 patients. Brain. 130(Pt 12):3091-101, 2007
                                  Related Anatomy
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                                  Related Differential Diagnoses
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                                  References
                                  Tables

                                  Tables

                                  KEY FACTS

                                  • Terminology

                                    • Imaging

                                      • Pathology

                                        • Clinical Issues

                                          TERMINOLOGY

                                          • Abbreviations

                                            • Reversible cerebral vasoconstriction syndrome (RCVS)
                                          • Synonyms

                                            • Call-Fleming syndrome
                                          • Definitions

                                            • Group of disorders characterized by
                                              • Reversible, multifocal cerebral artery vasoconstriction
                                              • Severe headaches (HA) ± focal neurological deficits

                                          IMAGING

                                          • General Features

                                            • CT Findings

                                              • MR Findings

                                                • Ultrasonographic Findings

                                                  • Angiographic Findings

                                                    DIFFERENTIAL DIAGNOSIS

                                                      PATHOLOGY

                                                      • General Features

                                                        CLINICAL ISSUES

                                                        • Presentation

                                                          • Natural History & Prognosis

                                                            • Treatment

                                                              DIAGNOSTIC CHECKLIST

                                                              • Consider

                                                                • Image Interpretation Pearls

                                                                  Selected References

                                                                  1. Kass-Hout T et al: A novel approach to diagnose reversible cerebral vasoconstriction syndrome: a case series. J Stroke Cerebrovasc Dis. 24(1):e31-7, 2015
                                                                  2. Agarwal R et al: Posterior reversible encephalopathy and cerebral vasoconstriction in a patient with hemolytic uremic syndrome. Pediatr Neurol. 50(5):518-21, 2014
                                                                  3. Calic Z et al: The Reversible Cerebral Vasoconstriction Syndrome. Intern Med J. ePub, 2014
                                                                  4. Grooters GS et al: How often is thunderclap headache caused by the reversible cerebral vasoconstriction syndrome? Headache. 54(4):732-5, 2014
                                                                  5. Katz BS et al: Clinical worsening in reversible cerebral vasoconstriction syndrome. JAMA Neurol. 71(1):68-73, 2014
                                                                  6. Wolff V et al: Ischaemic Strokes with Reversible Vasoconstriction and without Thunderclap Headache: A Variant of the Reversible Cerebral Vasoconstriction Syndrome? Cerebrovasc Dis. 39(1):31-38, 2014
                                                                  7. Muehlschlegel S et al: Differentiating reversible cerebral vasoconstriction syndrome with subarachnoid hemorrhage from other causes of subarachnoid hemorrhage. JAMA Neurol. 70(10):1254-60, 2013
                                                                  8. Marder CP et al: Multimodal imaging of reversible cerebral vasoconstriction syndrome: a series of 6 cases. AJNR Am J Neuroradiol. 33(7):1403-11, 2012
                                                                  9. Ducros A et al: The clinical and radiological spectrum of reversible cerebral vasoconstriction syndrome. A prospective series of 67 patients. Brain. 130(Pt 12):3091-101, 2007