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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Abbreviations
- Rhabdomyosarcoma (RMS)
Definitions
- Malignant neoplasm arising from rhabdomyoblasts
- Most common childhood soft tissue sarcoma
IMAGING
General Features
CT Findings
MR Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Selected References
- Kim JK et al: Patterns of radiotherapy use and outcomes in head and neck soft-tissue sarcoma in a national cohort. Laryngoscope. ePub, 2019
- Turpin B et al: Sentinel lymph node biopsy in head and neck rhabdomyosarcoma. Pediatr Blood Cancer. 66(3):e27532, 2019
- Häußler SM et al: Head and neck rhabdomyosarcoma in children: a 20-year retrospective study at a tertiary referral center. J Cancer Res Clin Oncol. 144(2):371-9, 2018
- Chevallier KM et al: Differentiating pediatric rhabdomyosarcoma and Langerhans cell histiocytosis of the temporal bone by imaging appearance. AJNR Am J Neuroradiol. ePub, 2016
- Hosoi H: Current status of treatment for pediatric rhabdomyosarcoma in the USA and Japan. Pediatr Int. 58(2):81-7, 2016
- Gluth MB: Rhabdomyosarcoma and other pediatric temporal bone malignancies. Otolaryngol Clin North Am. 48(2):375-90, 2015
- Kubo T et al: Prognostic value of PAX3/7-FOXO1 fusion status in alveolar rhabdomyosarcoma: Systematic review and meta-analysis. Crit Rev Oncol Hematol. 96(1):46-53, 2015
- Norman G et al: An emerging evidence base for PET-CT in the management of childhood rhabdomyosarcoma: systematic review. BMJ Open. 5(1):e006030, 2015
- Norman G et al: Mind the gap: extent of use of diffusion-weighted MRI in children with rhabdomyosarcoma. Pediatr Radiol. 45(5):778-81, 2015
- Sun X et al: Rhabdomyosarcoma: advances in molecular and cellular biology. Sarcoma. 2015:232010, 2015
- Malempati S et al: Rhabdomyosarcoma: review of the Children's Oncology Group (COG) Soft-Tissue Sarcoma Committee experience and rationale for current COG studies. Pediatr Blood Cancer. 59(1):5-10, 2012
- Hecker RM et al: p21 Downregulation is an important component of PAX3/FKHR oncogenicity and its reactivation by HDAC inhibitors enhances combination treatment. Oncogene. 29(27):3942-52, 2010
- Zevallos JP et al: Modern multimodality therapy for pediatric nonorbital parameningeal sarcomas. Head Neck. 32(11):1501-5, 2010
- Davicioni E et al: Molecular classification of rhabdomyosarcoma--genotypic and phenotypic determinants of diagnosis: a report from the Children's Oncology Group. Am J Pathol. 174(2):550-64, 2009
- Wharam MD et al: Failure pattern and factors predictive of local failure in rhabdomyosarcoma: a report of group III patients on the third Intergroup Rhabdomyosarcoma Study. J Clin Oncol. 22(10):1902-8, 2004
- Breneman JC et al: Prognostic factors and clinical outcomes in children and adolescents with metastatic rhabdomyosarcoma--a report from the Intergroup Rhabdomyosarcoma Study IV. J Clin Oncol. 21(1):78-84, 2003
- Simon JH et al: Prognostic factors in head and neck rhabdomyosarcoma. Head Neck. 24(5):468-73, 2002
- McCarville MB et al: Rhabdomyosarcoma in pediatric patients: the good, the bad, and the unusual. AJR Am J Roentgenol. 176(6):1563-9, 2001
- Castillo M et al: Rhabdomyosarcoma of the middle ear: imaging features in two children. AJNR Am J Neuroradiol. 14(3):730-3, 1993
- Yousem DM et al: Rhabdomyosarcomas in the head and neck: MR imaging evaluation. Radiology. 177(3):683-6, 1990
- Latack JT et al: Imaging of rhabdomyosarcomas of the head and neck. AJNR Am J Neuroradiol. 8(2):353-9, 1987
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Abbreviations
- Rhabdomyosarcoma (RMS)
Definitions
- Malignant neoplasm arising from rhabdomyoblasts
- Most common childhood soft tissue sarcoma
IMAGING
General Features
CT Findings
MR Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Selected References
- Kim JK et al: Patterns of radiotherapy use and outcomes in head and neck soft-tissue sarcoma in a national cohort. Laryngoscope. ePub, 2019
- Turpin B et al: Sentinel lymph node biopsy in head and neck rhabdomyosarcoma. Pediatr Blood Cancer. 66(3):e27532, 2019
- Häußler SM et al: Head and neck rhabdomyosarcoma in children: a 20-year retrospective study at a tertiary referral center. J Cancer Res Clin Oncol. 144(2):371-9, 2018
- Chevallier KM et al: Differentiating pediatric rhabdomyosarcoma and Langerhans cell histiocytosis of the temporal bone by imaging appearance. AJNR Am J Neuroradiol. ePub, 2016
- Hosoi H: Current status of treatment for pediatric rhabdomyosarcoma in the USA and Japan. Pediatr Int. 58(2):81-7, 2016
- Gluth MB: Rhabdomyosarcoma and other pediatric temporal bone malignancies. Otolaryngol Clin North Am. 48(2):375-90, 2015
- Kubo T et al: Prognostic value of PAX3/7-FOXO1 fusion status in alveolar rhabdomyosarcoma: Systematic review and meta-analysis. Crit Rev Oncol Hematol. 96(1):46-53, 2015
- Norman G et al: An emerging evidence base for PET-CT in the management of childhood rhabdomyosarcoma: systematic review. BMJ Open. 5(1):e006030, 2015
- Norman G et al: Mind the gap: extent of use of diffusion-weighted MRI in children with rhabdomyosarcoma. Pediatr Radiol. 45(5):778-81, 2015
- Sun X et al: Rhabdomyosarcoma: advances in molecular and cellular biology. Sarcoma. 2015:232010, 2015
- Malempati S et al: Rhabdomyosarcoma: review of the Children's Oncology Group (COG) Soft-Tissue Sarcoma Committee experience and rationale for current COG studies. Pediatr Blood Cancer. 59(1):5-10, 2012
- Hecker RM et al: p21 Downregulation is an important component of PAX3/FKHR oncogenicity and its reactivation by HDAC inhibitors enhances combination treatment. Oncogene. 29(27):3942-52, 2010
- Zevallos JP et al: Modern multimodality therapy for pediatric nonorbital parameningeal sarcomas. Head Neck. 32(11):1501-5, 2010
- Davicioni E et al: Molecular classification of rhabdomyosarcoma--genotypic and phenotypic determinants of diagnosis: a report from the Children's Oncology Group. Am J Pathol. 174(2):550-64, 2009
- Wharam MD et al: Failure pattern and factors predictive of local failure in rhabdomyosarcoma: a report of group III patients on the third Intergroup Rhabdomyosarcoma Study. J Clin Oncol. 22(10):1902-8, 2004
- Breneman JC et al: Prognostic factors and clinical outcomes in children and adolescents with metastatic rhabdomyosarcoma--a report from the Intergroup Rhabdomyosarcoma Study IV. J Clin Oncol. 21(1):78-84, 2003
- Simon JH et al: Prognostic factors in head and neck rhabdomyosarcoma. Head Neck. 24(5):468-73, 2002
- McCarville MB et al: Rhabdomyosarcoma in pediatric patients: the good, the bad, and the unusual. AJR Am J Roentgenol. 176(6):1563-9, 2001
- Castillo M et al: Rhabdomyosarcoma of the middle ear: imaging features in two children. AJNR Am J Neuroradiol. 14(3):730-3, 1993
- Yousem DM et al: Rhabdomyosarcomas in the head and neck: MR imaging evaluation. Radiology. 177(3):683-6, 1990
- Latack JT et al: Imaging of rhabdomyosarcomas of the head and neck. AJNR Am J Neuroradiol. 8(2):353-9, 1987
