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Rheumatoid Arthritis of Knee
Eva M. Escobedo, MD; Stephanie A. Bernard, MD; B. J. Manaster, MD, PhD, FACR
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KEY FACTS

  • Imaging

    • Clinical Issues

      • Diagnostic Checklist

        TERMINOLOGY

        • Abbreviations

          • Rheumatoid arthritis (RA)
        • Definitions

          • Chronic progressive systemic inflammatory disease in which joints are primary target

        IMAGING

        • General Features

          • Radiographic Findings

            • CT Findings

              • MR Findings

                • Ultrasonographic Findings

                  • Imaging Recommendations

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • General Features

                        • Staging, Grading, & Classification

                          • Gross Pathologic & Surgical Features

                            • Microscopic Features

                              CLINICAL ISSUES

                              • Presentation

                                • Demographics

                                  • Natural History & Prognosis

                                    • Treatment

                                      DIAGNOSTIC CHECKLIST

                                      • Consider

                                        • Image Interpretation Pearls

                                          Selected References

                                          1. Baek JH et al: Inferior outcomes of primary total knee arthroplasty in patients with rheumatoid arthritis compared to patients with osteoarthritis. Knee Surg Sports Traumatol Arthrosc. ePub, 2021
                                          2. Xiao L et al: Knee alterations in rheumatoid arthritis: comparison of US and MRI. Open Med (Wars). 16(1):913-8, 2021
                                          3. Meng XH et al: Rheumatoid arthritis of knee joints: MRI-pathological correlation. Orthop Surg. 10(3):247-54, 2018
                                          4. Schäfer VS et al: Arthritis of the knee joint in rheumatoid arthritis - evaluation of treatment response by ultrasound in daily clinical practice. Open Rheumatol J. 10:81-7, 2016
                                          5. Nikiphorou E et al: The effect of disease severity and comorbidity on length of stay for orthopedic surgery in rheumatoid arthritis: results from 2 UK inception cohorts, 1986-2012. J Rheumatol. 42(5):778-85, 2015
                                          6. Yoo JD et al: Periprosthetic fractures following total knee arthroplasty. Knee Surg Relat Res. 27(1):1-9, 2015
                                          7. Flemming DJ et al: MR imaging assessment of arthritis of the knee. Magn Reson Imaging Clin N Am. 22(4):703-24, 2014
                                          8. Singh JA et al: Rheumatoid arthritis is associated with higher 90-day hospital readmission rates compared to osteoarthritis after hip or knee arthroplasty: a cohort study. Arthritis Care Res (Hoboken). 67(5):718-24, 2014
                                          9. Dirven L et al: Large-joint damage in patients with early rheumatoid arthritis and its association with treatment strategy and damage of the small joints. Rheumatology (Oxford). 51(12):2262-8, 2012
                                          10. Hartung W et al: Development and evaluation of a novel ultrasound score for large joints in rheumatoid arthritis: one year of experience in daily clinical practice. Arthritis Care Res (Hoboken). 64(5):675-82, 2012
                                          11. Bøyesen P et al: Prediction of MRI erosive progression: a comparison of modern imaging modalities in early rheumatoid arthritis patients. Ann Rheum Dis. 70(1):176-9, 2011
                                          12. Aletaha D et al: 2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Arthritis Rheum. 62(9):2569-81, 2010
                                          13. Narváez JA et al: MR imaging of early rheumatoid arthritis. Radiographics. 30(1):143-63; discussion 163-5, 2010
                                          14. Emad Y et al: Can magnetic resonance imaging differentiate undifferentiated arthritis based on knee imaging? J Rheumatol. 36(9):1963-70, 2009
                                          15. Jämsen E et al: Risk factors for infection after knee arthroplasty. A register-based analysis of 43,149 cases. J Bone Joint Surg Am. 91(1):38-47, 2009
                                          16. Seki E et al: Radiographic progression in weight-bearing joints of patients with rheumatoid arthritis after TNF-blocking therapies. Clin Rheumatol. 28(4):453-60, 2009
                                          17. Bongartz T et al: Incidence and risk factors of prosthetic joint infection after total hip or knee replacement in patients with rheumatoid arthritis. Arthritis Rheum. 59(12):1713-20, 2008
                                          18. Chattopadhyay S et al: Preparation and evaluation of a new radiopharmaceutical for radiosynovectomy, 111Ag-labelled hydroxyapatite (HA) particles. Appl Radiat Isot. 66(3):334-9, 2008
                                          19. Chrapko B et al: Radiation synovectomy with 90Y colloid in the therapy of recurrent knee joint effusions in patients with inflammatory joint diseases. Rheumatol Int. 27(8):729-34, 2007
                                          20. Frick MA et al: MR imaging of synovial disorders of the knee: an update. Radiol Clin North Am. 45(6):1017-31, vii, 2007
                                          21. Linn-Rasker SP et al: Arthritis of the large joints - in particular, the knee - at first presentation is predictive for a high level of radiological destruction of the small joints in rheumatoid arthritis. Ann Rheum Dis. 66(5):646-50, 2007
                                          22. Ter Braak BP et al: Are radiographs needed when MR imaging is performed for non-acute knee symptoms in patients younger than 45 years of age? Skeletal Radiol. 36(12):1129-39, 2007
                                          23. Beckers C et al: (18)F-FDG PET imaging of rheumatoid knee synovitis correlates with dynamic magnetic resonance and sonographic assessments as well as with the serum level of metalloproteinase-3. Eur J Nucl Med Mol Imaging. 33(3):275-80, 2006
                                          24. Gandy SJ et al: Measurement of cartilage volumes in rheumatoid arthritis using MRI. Br J Radiol. 78(925):39-45, 2005
                                          25. Rhodes LA et al: Further evidence that a cartilage-pannus junction synovitis predilection is not a specific feature of rheumatoid arthritis. Ann Rheum Dis. 64(9):1347-9, 2005
                                          26. Forslind K et al: Magnetic resonance imaging of the knee: a tool for prediction of joint damage in early rheumatoid arthritis? Scand J Rheumatol. 33(3):154-61, 2004
                                          27. Rhodes LA et al: Regional variation and differential response to therapy for knee synovitis adjacent to the cartilage-pannus junction and suprapatellar pouch in inflammatory arthritis: implications for pathogenesis and treatment. Arthritis Rheum. 50(8):2428-32, 2004
                                          28. Kane D et al: Ultrasonography is superior to clinical examination in the detection and localization of knee joint effusion in rheumatoid arthritis. J Rheumatol. 30(5):966-71, 2003
                                          29. Drossaers-Bakker KW et al: Radiographic damage of large joints in long-term rheumatoid arthritis and its relation to function. Rheumatology (Oxford). 39(9):998-1003, 2000
                                          Related Anatomy
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                                          Related Differential Diagnoses
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                                          References
                                          Tables

                                          Tables

                                          KEY FACTS

                                          • Imaging

                                            • Clinical Issues

                                              • Diagnostic Checklist

                                                TERMINOLOGY

                                                • Abbreviations

                                                  • Rheumatoid arthritis (RA)
                                                • Definitions

                                                  • Chronic progressive systemic inflammatory disease in which joints are primary target

                                                IMAGING

                                                • General Features

                                                  • Radiographic Findings

                                                    • CT Findings

                                                      • MR Findings

                                                        • Ultrasonographic Findings

                                                          • Imaging Recommendations

                                                            DIFFERENTIAL DIAGNOSIS

                                                              PATHOLOGY

                                                              • General Features

                                                                • Staging, Grading, & Classification

                                                                  • Gross Pathologic & Surgical Features

                                                                    • Microscopic Features

                                                                      CLINICAL ISSUES

                                                                      • Presentation

                                                                        • Demographics

                                                                          • Natural History & Prognosis

                                                                            • Treatment

                                                                              DIAGNOSTIC CHECKLIST

                                                                              • Consider

                                                                                • Image Interpretation Pearls

                                                                                  Selected References

                                                                                  1. Baek JH et al: Inferior outcomes of primary total knee arthroplasty in patients with rheumatoid arthritis compared to patients with osteoarthritis. Knee Surg Sports Traumatol Arthrosc. ePub, 2021
                                                                                  2. Xiao L et al: Knee alterations in rheumatoid arthritis: comparison of US and MRI. Open Med (Wars). 16(1):913-8, 2021
                                                                                  3. Meng XH et al: Rheumatoid arthritis of knee joints: MRI-pathological correlation. Orthop Surg. 10(3):247-54, 2018
                                                                                  4. Schäfer VS et al: Arthritis of the knee joint in rheumatoid arthritis - evaluation of treatment response by ultrasound in daily clinical practice. Open Rheumatol J. 10:81-7, 2016
                                                                                  5. Nikiphorou E et al: The effect of disease severity and comorbidity on length of stay for orthopedic surgery in rheumatoid arthritis: results from 2 UK inception cohorts, 1986-2012. J Rheumatol. 42(5):778-85, 2015
                                                                                  6. Yoo JD et al: Periprosthetic fractures following total knee arthroplasty. Knee Surg Relat Res. 27(1):1-9, 2015
                                                                                  7. Flemming DJ et al: MR imaging assessment of arthritis of the knee. Magn Reson Imaging Clin N Am. 22(4):703-24, 2014
                                                                                  8. Singh JA et al: Rheumatoid arthritis is associated with higher 90-day hospital readmission rates compared to osteoarthritis after hip or knee arthroplasty: a cohort study. Arthritis Care Res (Hoboken). 67(5):718-24, 2014
                                                                                  9. Dirven L et al: Large-joint damage in patients with early rheumatoid arthritis and its association with treatment strategy and damage of the small joints. Rheumatology (Oxford). 51(12):2262-8, 2012
                                                                                  10. Hartung W et al: Development and evaluation of a novel ultrasound score for large joints in rheumatoid arthritis: one year of experience in daily clinical practice. Arthritis Care Res (Hoboken). 64(5):675-82, 2012
                                                                                  11. Bøyesen P et al: Prediction of MRI erosive progression: a comparison of modern imaging modalities in early rheumatoid arthritis patients. Ann Rheum Dis. 70(1):176-9, 2011
                                                                                  12. Aletaha D et al: 2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Arthritis Rheum. 62(9):2569-81, 2010
                                                                                  13. Narváez JA et al: MR imaging of early rheumatoid arthritis. Radiographics. 30(1):143-63; discussion 163-5, 2010
                                                                                  14. Emad Y et al: Can magnetic resonance imaging differentiate undifferentiated arthritis based on knee imaging? J Rheumatol. 36(9):1963-70, 2009
                                                                                  15. Jämsen E et al: Risk factors for infection after knee arthroplasty. A register-based analysis of 43,149 cases. J Bone Joint Surg Am. 91(1):38-47, 2009
                                                                                  16. Seki E et al: Radiographic progression in weight-bearing joints of patients with rheumatoid arthritis after TNF-blocking therapies. Clin Rheumatol. 28(4):453-60, 2009
                                                                                  17. Bongartz T et al: Incidence and risk factors of prosthetic joint infection after total hip or knee replacement in patients with rheumatoid arthritis. Arthritis Rheum. 59(12):1713-20, 2008
                                                                                  18. Chattopadhyay S et al: Preparation and evaluation of a new radiopharmaceutical for radiosynovectomy, 111Ag-labelled hydroxyapatite (HA) particles. Appl Radiat Isot. 66(3):334-9, 2008
                                                                                  19. Chrapko B et al: Radiation synovectomy with 90Y colloid in the therapy of recurrent knee joint effusions in patients with inflammatory joint diseases. Rheumatol Int. 27(8):729-34, 2007
                                                                                  20. Frick MA et al: MR imaging of synovial disorders of the knee: an update. Radiol Clin North Am. 45(6):1017-31, vii, 2007
                                                                                  21. Linn-Rasker SP et al: Arthritis of the large joints - in particular, the knee - at first presentation is predictive for a high level of radiological destruction of the small joints in rheumatoid arthritis. Ann Rheum Dis. 66(5):646-50, 2007
                                                                                  22. Ter Braak BP et al: Are radiographs needed when MR imaging is performed for non-acute knee symptoms in patients younger than 45 years of age? Skeletal Radiol. 36(12):1129-39, 2007
                                                                                  23. Beckers C et al: (18)F-FDG PET imaging of rheumatoid knee synovitis correlates with dynamic magnetic resonance and sonographic assessments as well as with the serum level of metalloproteinase-3. Eur J Nucl Med Mol Imaging. 33(3):275-80, 2006
                                                                                  24. Gandy SJ et al: Measurement of cartilage volumes in rheumatoid arthritis using MRI. Br J Radiol. 78(925):39-45, 2005
                                                                                  25. Rhodes LA et al: Further evidence that a cartilage-pannus junction synovitis predilection is not a specific feature of rheumatoid arthritis. Ann Rheum Dis. 64(9):1347-9, 2005
                                                                                  26. Forslind K et al: Magnetic resonance imaging of the knee: a tool for prediction of joint damage in early rheumatoid arthritis? Scand J Rheumatol. 33(3):154-61, 2004
                                                                                  27. Rhodes LA et al: Regional variation and differential response to therapy for knee synovitis adjacent to the cartilage-pannus junction and suprapatellar pouch in inflammatory arthritis: implications for pathogenesis and treatment. Arthritis Rheum. 50(8):2428-32, 2004
                                                                                  28. Kane D et al: Ultrasonography is superior to clinical examination in the detection and localization of knee joint effusion in rheumatoid arthritis. J Rheumatol. 30(5):966-71, 2003
                                                                                  29. Drossaers-Bakker KW et al: Radiographic damage of large joints in long-term rheumatoid arthritis and its relation to function. Rheumatology (Oxford). 39(9):998-1003, 2000