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Rheumatoid Nodule
Stephanie A. Bernard, MD; Catherine C. Roberts, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Pathology

        • Clinical Issues

          TERMINOLOGY

          • Abbreviations

            • Rheumatoid arthritis (RA)
          • Definitions

            • Inflammatory soft tissue nodule that is most common extraarticular manifestation of RA

          IMAGING

          • General Features

            • Radiographic Findings

              • MR Findings

                • Ultrasonographic Findings

                  • Nuclear Medicine Findings

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • General Features

                        • Microscopic Features

                          • Molecular/Cytogenetics/Stains

                            CLINICAL ISSUES

                            • Presentation

                              • Demographics

                                • Natural History & Prognosis

                                  • Treatment

                                    Selected References

                                    1. Murphy D et al: Nodular rheumatoid arthritis (RA): a distinct disease subtype, initiated by cadmium inhalation inducing pulmonary nodule formation and subsequent RA-associated autoantibody generation. Med Hypotheses. 122:48-55, 2019
                                    2. Marcucci E et al: Extra-articular rheumatoid arthritis. Reumatismo. 70(4):212-24, 2018
                                    3. Verheul MK et al: Triple positivity for anti-citrullinated protein autoantibodies, rheumatoid factor, and anti-carbamylated protein antibodies conferring high specificity for rheumatoid arthritis: implications for very early identification of at-risk individuals. Arthritis Rheumatol. 70(11):1721-31, 2018
                                    4. Tilstra JS et al: Rheumatoid nodules. Dermatol Clin. 33(3):361-71, 2015
                                    5. Plymale M et al: Isolated intra-articular pseudorheumatoid nodule of the knee. Skeletal Radiol. 40(4):463-6, 2011
                                    6. Amini S et al: A novel treatment for rheumatoid nodules (RN) with intralesional fluorouracil. Int J Dermatol. 48(5):543-6, 2009
                                    7. Strobel K et al: FDG uptake in a rheumatoid nodule with imaging appearance similar to a malignant soft tissue tumor. Clin Nucl Med. 34(10):691-2, 2009
                                    8. Thinda S et al: Mesenteric rheumatoid nodules masquerading as an intra-abdominal malignancy: a case report and review of the literature. World J Surg Oncol. 7:59, 2009
                                    9. Knoess M et al: Colocalization of C4d deposits/CD68+ macrophages in rheumatoid nodule and granuloma annulare: immunohistochemical evidence of a complement-mediated mechanism in fibrinoid necrosis. Pathol Res Pract. 204(6):373-8, 2008
                                    10. Osanai T et al: Large benign rheumatoid nodules of the trunk in an elderly patient: radiologic appearance mimicking a soft-tissue sarcoma. Mod Rheumatol. 16(5):312-5, 2006
                                    11. Resnick D: Rheumatoid arthritis and the seronegative spondyloarthropathies: radiographic and pathologic concepts. In Resnick D et al: Diagnosis of Bone and Joint Disorders. 4th ed. W.B. Saunders. 860-3, 2002
                                    12. Sanders TG et al: Rheumatoid nodule of the foot: MRI appearances mimicking an indeterminate soft tissue mass. Skeletal Radiol. 27(8):457-60, 1998
                                    13. Starok M et al: Rheumatoid nodules: MRI characteristics. Clin Imaging. 22(3):216-9, 1998
                                    Related Anatomy
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                                    Related Differential Diagnoses
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                                    References
                                    Tables

                                    Tables

                                    KEY FACTS

                                    • Terminology

                                      • Imaging

                                        • Pathology

                                          • Clinical Issues

                                            TERMINOLOGY

                                            • Abbreviations

                                              • Rheumatoid arthritis (RA)
                                            • Definitions

                                              • Inflammatory soft tissue nodule that is most common extraarticular manifestation of RA

                                            IMAGING

                                            • General Features

                                              • Radiographic Findings

                                                • MR Findings

                                                  • Ultrasonographic Findings

                                                    • Nuclear Medicine Findings

                                                      DIFFERENTIAL DIAGNOSIS

                                                        PATHOLOGY

                                                        • General Features

                                                          • Microscopic Features

                                                            • Molecular/Cytogenetics/Stains

                                                              CLINICAL ISSUES

                                                              • Presentation

                                                                • Demographics

                                                                  • Natural History & Prognosis

                                                                    • Treatment

                                                                      Selected References

                                                                      1. Murphy D et al: Nodular rheumatoid arthritis (RA): a distinct disease subtype, initiated by cadmium inhalation inducing pulmonary nodule formation and subsequent RA-associated autoantibody generation. Med Hypotheses. 122:48-55, 2019
                                                                      2. Marcucci E et al: Extra-articular rheumatoid arthritis. Reumatismo. 70(4):212-24, 2018
                                                                      3. Verheul MK et al: Triple positivity for anti-citrullinated protein autoantibodies, rheumatoid factor, and anti-carbamylated protein antibodies conferring high specificity for rheumatoid arthritis: implications for very early identification of at-risk individuals. Arthritis Rheumatol. 70(11):1721-31, 2018
                                                                      4. Tilstra JS et al: Rheumatoid nodules. Dermatol Clin. 33(3):361-71, 2015
                                                                      5. Plymale M et al: Isolated intra-articular pseudorheumatoid nodule of the knee. Skeletal Radiol. 40(4):463-6, 2011
                                                                      6. Amini S et al: A novel treatment for rheumatoid nodules (RN) with intralesional fluorouracil. Int J Dermatol. 48(5):543-6, 2009
                                                                      7. Strobel K et al: FDG uptake in a rheumatoid nodule with imaging appearance similar to a malignant soft tissue tumor. Clin Nucl Med. 34(10):691-2, 2009
                                                                      8. Thinda S et al: Mesenteric rheumatoid nodules masquerading as an intra-abdominal malignancy: a case report and review of the literature. World J Surg Oncol. 7:59, 2009
                                                                      9. Knoess M et al: Colocalization of C4d deposits/CD68+ macrophages in rheumatoid nodule and granuloma annulare: immunohistochemical evidence of a complement-mediated mechanism in fibrinoid necrosis. Pathol Res Pract. 204(6):373-8, 2008
                                                                      10. Osanai T et al: Large benign rheumatoid nodules of the trunk in an elderly patient: radiologic appearance mimicking a soft-tissue sarcoma. Mod Rheumatol. 16(5):312-5, 2006
                                                                      11. Resnick D: Rheumatoid arthritis and the seronegative spondyloarthropathies: radiographic and pathologic concepts. In Resnick D et al: Diagnosis of Bone and Joint Disorders. 4th ed. W.B. Saunders. 860-3, 2002
                                                                      12. Sanders TG et al: Rheumatoid nodule of the foot: MRI appearances mimicking an indeterminate soft tissue mass. Skeletal Radiol. 27(8):457-60, 1998
                                                                      13. Starok M et al: Rheumatoid nodules: MRI characteristics. Clin Imaging. 22(3):216-9, 1998