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Rosai-Dorfman Disease
Miral D. Jhaveri, MD, MBA
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Abbreviations

              • Rosai-Dorfman disease (RDD)
            • Synonyms

              • Sinus histiocytosis (SH) with massive lymphadenopathy
            • Definitions

              • Histioproliferative disorder of unknown etiology

            IMAGING

            • General Features

              • CT Findings

                • MR Findings

                  • Nuclear Medicine Findings

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • General Features

                        • Gross Pathologic & Surgical Features

                          • Microscopic Features

                            CLINICAL ISSUES

                            • Presentation

                              • Demographics

                                • Natural History & Prognosis

                                  • Treatment

                                    DIAGNOSTIC CHECKLIST

                                    • Image Interpretation Pearls

                                      Selected References

                                      1. Abla O Dr. et al: Consensus recommendations for the diagnosis and clinical management of Rosai-Dorfman-Destombes disease. Blood. Jun 28;131(26):2877-90, 2018
                                      2. Cohen Aubart F et al: [Rosai-Dorfman disease: diagnosis and therapeutic challenges.] Rev Med Interne. 39(8):635-40, 2018
                                      3. Cai Y et al: Review of Rosai-Dorfman disease: new insights into the pathogenesis of this rare disorder. Acta Haematol. 138(1):14-23, 2017
                                      4. Xu Q et al: Multimodality imaging-based evaluation of Rosai-Dorfman disease in the head and neck: A retrospective observational study. Medicine (Baltimore). 96(51):e9372, 2017
                                      5. Dalia S et al: Rosai-Dorfman disease: tumor biology, clinical features, pathology, and treatment. Cancer Control. 21(4):322-7, 2014
                                      6. La Barge DV 3rd et al: Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease): imaging manifestations in the head and neck. AJR Am J Roentgenol. 191(6):W299-306, 2008
                                      7. Ottaviano G et al: Extranodal Rosai-Dorfman disease: involvement of eye, nose and trachea. Acta Otolaryngol. 126(6):657-60, 2006
                                      Related Anatomy
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                                      Related Differential Diagnoses
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                                      References
                                      Tables

                                      Tables

                                      KEY FACTS

                                      • Terminology

                                        • Imaging

                                          • Top Differential Diagnoses

                                            • Pathology

                                              • Clinical Issues

                                                TERMINOLOGY

                                                • Abbreviations

                                                  • Rosai-Dorfman disease (RDD)
                                                • Synonyms

                                                  • Sinus histiocytosis (SH) with massive lymphadenopathy
                                                • Definitions

                                                  • Histioproliferative disorder of unknown etiology

                                                IMAGING

                                                • General Features

                                                  • CT Findings

                                                    • MR Findings

                                                      • Nuclear Medicine Findings

                                                        DIFFERENTIAL DIAGNOSIS

                                                          PATHOLOGY

                                                          • General Features

                                                            • Gross Pathologic & Surgical Features

                                                              • Microscopic Features

                                                                CLINICAL ISSUES

                                                                • Presentation

                                                                  • Demographics

                                                                    • Natural History & Prognosis

                                                                      • Treatment

                                                                        DIAGNOSTIC CHECKLIST

                                                                        • Image Interpretation Pearls

                                                                          Selected References

                                                                          1. Abla O Dr. et al: Consensus recommendations for the diagnosis and clinical management of Rosai-Dorfman-Destombes disease. Blood. Jun 28;131(26):2877-90, 2018
                                                                          2. Cohen Aubart F et al: [Rosai-Dorfman disease: diagnosis and therapeutic challenges.] Rev Med Interne. 39(8):635-40, 2018
                                                                          3. Cai Y et al: Review of Rosai-Dorfman disease: new insights into the pathogenesis of this rare disorder. Acta Haematol. 138(1):14-23, 2017
                                                                          4. Xu Q et al: Multimodality imaging-based evaluation of Rosai-Dorfman disease in the head and neck: A retrospective observational study. Medicine (Baltimore). 96(51):e9372, 2017
                                                                          5. Dalia S et al: Rosai-Dorfman disease: tumor biology, clinical features, pathology, and treatment. Cancer Control. 21(4):322-7, 2014
                                                                          6. La Barge DV 3rd et al: Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease): imaging manifestations in the head and neck. AJR Am J Roentgenol. 191(6):W299-306, 2008
                                                                          7. Ottaviano G et al: Extranodal Rosai-Dorfman disease: involvement of eye, nose and trachea. Acta Otolaryngol. 126(6):657-60, 2006