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Salivary Gland Amyloidosis
Carmen C. Cho, MBBS, FRCR; Kunwar S. S. Bhatia, MBBS, FRCR; Anil T. Ahuja, MD, FRCR
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Diagnostic Checklist

          TERMINOLOGY

          • Abbreviations

            • Salivary gland (SG)
          • Definitions

            • Abnormal extracellular deposition of amyloid within salivary parenchyma
              • Amyloid refers to variety of insoluble proteins with specific properties
                • β-pleated sheet structure on x-ray crystallography
                • Apple-green birefringence under polarized light with Congo red staining
                • Amorphous eosinophilic appearance on H&E stain

          IMAGING

          • General Features

            • Ultrasonographic Findings

              • CT Findings

                • MR Findings

                  • Imaging Recommendations

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • General Features

                        • Staging, Grading, & Classification

                          • Gross Pathologic & Surgical Features

                            CLINICAL ISSUES

                            • Presentation

                              • Natural History & Prognosis

                                • Treatment

                                  DIAGNOSTIC CHECKLIST

                                  • Consider

                                    • Image Interpretation Pearls

                                      Selected References

                                      1. Gareb B et al: Isolated light chain amyloidosis involving the parotid gland: a case report. J Oral Maxillofac Surg. 76(9):1917-1924, 2018
                                      2. Finkel KJ et al: Amyloid infiltration of the salivary glands in the setting of primary systemic amyloidosis without multiple myeloma. Otolaryngol Head Neck Surg. 135(3):471-2, 2006
                                      Related Anatomy
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                                      Related Differential Diagnoses
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                                      References
                                      Tables

                                      Tables

                                      KEY FACTS

                                      • Terminology

                                        • Imaging

                                          • Top Differential Diagnoses

                                            • Diagnostic Checklist

                                              TERMINOLOGY

                                              • Abbreviations

                                                • Salivary gland (SG)
                                              • Definitions

                                                • Abnormal extracellular deposition of amyloid within salivary parenchyma
                                                  • Amyloid refers to variety of insoluble proteins with specific properties
                                                    • β-pleated sheet structure on x-ray crystallography
                                                    • Apple-green birefringence under polarized light with Congo red staining
                                                    • Amorphous eosinophilic appearance on H&E stain

                                              IMAGING

                                              • General Features

                                                • Ultrasonographic Findings

                                                  • CT Findings

                                                    • MR Findings

                                                      • Imaging Recommendations

                                                        DIFFERENTIAL DIAGNOSIS

                                                          PATHOLOGY

                                                          • General Features

                                                            • Staging, Grading, & Classification

                                                              • Gross Pathologic & Surgical Features

                                                                CLINICAL ISSUES

                                                                • Presentation

                                                                  • Natural History & Prognosis

                                                                    • Treatment

                                                                      DIAGNOSTIC CHECKLIST

                                                                      • Consider

                                                                        • Image Interpretation Pearls

                                                                          Selected References

                                                                          1. Gareb B et al: Isolated light chain amyloidosis involving the parotid gland: a case report. J Oral Maxillofac Surg. 76(9):1917-1924, 2018
                                                                          2. Finkel KJ et al: Amyloid infiltration of the salivary glands in the setting of primary systemic amyloidosis without multiple myeloma. Otolaryngol Head Neck Surg. 135(3):471-2, 2006