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Salivary Gland Lymphoepithelioma-Like Carcinoma
Carmen C. Cho, MBBS, FRCR; Eunice Y. L. Dai, MBBS, FRCR; Anil T. Ahuja, MD, FRCR
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          TERMINOLOGY

          • Abbreviations

            • Lymphoepithelioma-like carcinoma (LELC)
          • Synonyms

            • Lymphoepithelial carcinoma
            • Malignant lymphoepithelial lesion
            • Undifferentiated carcinoma with lymphoid stroma
            • Eskimoma (old term, no longer used)
          • Definitions

            • Malignant tumor with morphologic features identical to nonkeratinizing undifferentiated nasopharyngeal carcinoma (NPC), according to WHO classification

          IMAGING

          • General Features

            • Ultrasonographic Findings

              • CT Findings

                • MR Findings

                  • Imaging Recommendations

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • General Features

                        • Gross Pathologic & Surgical Features

                          • Microscopic Features

                            • Blood Tests

                              CLINICAL ISSUES

                              • Presentation

                                • Demographics

                                  • Natural History & Prognosis

                                    • Treatment

                                      DIAGNOSTIC CHECKLIST

                                      • Consider

                                        • Image Interpretation Pearls

                                          • Reporting Tips

                                            Selected References

                                            1. Wenig BM: Lymphoepithelial-like carcinomas of the head and neck. Semin Diagn Pathol. 32(1):74-86, 2015
                                            2. Ban X et al: Lymphoepithelial carcinoma of the salivary gland: morphologic patterns and imaging features on CT and MRI. AJNR Am J Neuroradiol. 35(9):1813-9, 2014
                                            3. Ambrosio MR et al: Lymphoepithelial-like carcinoma of the parotid gland: a case report and a brief review of the western literature. Diagn Pathol. 8(1):115, 2013
                                            4. Ma H et al: Primary lymphoepithelioma-like carcinoma of salivary gland: 69 cases with long-term follow-up. Head Neck. Epub ahead of print, 2013
                                            5. Friborg J et al: A spectrum of basaloid morphology in a subset of EBV-associated "lymphoepithelial carcinomas" of major salivary glands. Head Neck Pathol. 6(4):445-50, 2012
                                            6. Schneider M et al: Lymphoepithelial carcinoma of the parotid glands and its relationship with benign lymphoepithelial lesions. Arch Pathol Lab Med. 132(2):278-82, 2008
                                            7. Hsiung CY et al: Lymphoepithelioma-like carcinoma of salivary glands: treatment results and failure patterns. Br J Radiol. 79(937):52-5, 2006
                                            8. Wang CP et al: Lymphoepithelial carcinoma versus large cell undifferentiated carcinoma of the major salivary glands. Cancer. 101(9):2020-7, 2004
                                            9. Wu DL et al: Malignant lymphoepithelial lesion of the parotid gland: a case report and review of the literature. Ear Nose Throat J. 80(11):803-6, 2001
                                            10. Ahuja AT et al: Palatal lymphoepitheliomas and a review of head and neck lymphoepitheliomas. Clin Radiol. 54(5):289-93, 1999
                                            11. Dubey P et al: Nonnasopharyngeal lymphoepithelioma of the head and neck. Cancer. 82(8):1556-62, 1998
                                            12. Kuo T et al: Lymphoepithelioma-like salivary gland carcinoma in Taiwan: a clinicopathological study of nine cases demonstrating a strong association with Epstein-Barr virus. Histopathology. 31(1):75-82, 1997
                                            13. Abdulla AK et al: Lymphoepithelial carcinoma of salivary glands. Head Neck. 18(6):577-81, 1996
                                            Related Anatomy
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                                            Related Differential Diagnoses
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                                            References
                                            Tables

                                            Tables

                                            KEY FACTS

                                            • Terminology

                                              • Imaging

                                                • Top Differential Diagnoses

                                                  • Clinical Issues

                                                    TERMINOLOGY

                                                    • Abbreviations

                                                      • Lymphoepithelioma-like carcinoma (LELC)
                                                    • Synonyms

                                                      • Lymphoepithelial carcinoma
                                                      • Malignant lymphoepithelial lesion
                                                      • Undifferentiated carcinoma with lymphoid stroma
                                                      • Eskimoma (old term, no longer used)
                                                    • Definitions

                                                      • Malignant tumor with morphologic features identical to nonkeratinizing undifferentiated nasopharyngeal carcinoma (NPC), according to WHO classification

                                                    IMAGING

                                                    • General Features

                                                      • Ultrasonographic Findings

                                                        • CT Findings

                                                          • MR Findings

                                                            • Imaging Recommendations

                                                              DIFFERENTIAL DIAGNOSIS

                                                                PATHOLOGY

                                                                • General Features

                                                                  • Gross Pathologic & Surgical Features

                                                                    • Microscopic Features

                                                                      • Blood Tests

                                                                        CLINICAL ISSUES

                                                                        • Presentation

                                                                          • Demographics

                                                                            • Natural History & Prognosis

                                                                              • Treatment

                                                                                DIAGNOSTIC CHECKLIST

                                                                                • Consider

                                                                                  • Image Interpretation Pearls

                                                                                    • Reporting Tips

                                                                                      Selected References

                                                                                      1. Wenig BM: Lymphoepithelial-like carcinomas of the head and neck. Semin Diagn Pathol. 32(1):74-86, 2015
                                                                                      2. Ban X et al: Lymphoepithelial carcinoma of the salivary gland: morphologic patterns and imaging features on CT and MRI. AJNR Am J Neuroradiol. 35(9):1813-9, 2014
                                                                                      3. Ambrosio MR et al: Lymphoepithelial-like carcinoma of the parotid gland: a case report and a brief review of the western literature. Diagn Pathol. 8(1):115, 2013
                                                                                      4. Ma H et al: Primary lymphoepithelioma-like carcinoma of salivary gland: 69 cases with long-term follow-up. Head Neck. Epub ahead of print, 2013
                                                                                      5. Friborg J et al: A spectrum of basaloid morphology in a subset of EBV-associated "lymphoepithelial carcinomas" of major salivary glands. Head Neck Pathol. 6(4):445-50, 2012
                                                                                      6. Schneider M et al: Lymphoepithelial carcinoma of the parotid glands and its relationship with benign lymphoepithelial lesions. Arch Pathol Lab Med. 132(2):278-82, 2008
                                                                                      7. Hsiung CY et al: Lymphoepithelioma-like carcinoma of salivary glands: treatment results and failure patterns. Br J Radiol. 79(937):52-5, 2006
                                                                                      8. Wang CP et al: Lymphoepithelial carcinoma versus large cell undifferentiated carcinoma of the major salivary glands. Cancer. 101(9):2020-7, 2004
                                                                                      9. Wu DL et al: Malignant lymphoepithelial lesion of the parotid gland: a case report and review of the literature. Ear Nose Throat J. 80(11):803-6, 2001
                                                                                      10. Ahuja AT et al: Palatal lymphoepitheliomas and a review of head and neck lymphoepitheliomas. Clin Radiol. 54(5):289-93, 1999
                                                                                      11. Dubey P et al: Nonnasopharyngeal lymphoepithelioma of the head and neck. Cancer. 82(8):1556-62, 1998
                                                                                      12. Kuo T et al: Lymphoepithelioma-like salivary gland carcinoma in Taiwan: a clinicopathological study of nine cases demonstrating a strong association with Epstein-Barr virus. Histopathology. 31(1):75-82, 1997
                                                                                      13. Abdulla AK et al: Lymphoepithelial carcinoma of salivary glands. Head Neck. 18(6):577-81, 1996