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Salpingitis Isthmica Nodosa
Paula J. Woodward, MD
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KEY FACTS

  • Imaging

    • Top Differential Diagnoses

      • Pathology

        • Clinical Issues

          TERMINOLOGY

          • Abbreviations

            • Salpingitis isthmica nodosa (SIN)
          • Synonyms

            • Tubal diverticulosis
            • Tubal adenomyosis
          • Definitions

            • Small outpouchings or diverticula from isthmic portion of fallopian tube

          IMAGING

          • General Features

            • Hysterosalpingography (HSG)

              • MR Findings

                • Ultrasonographic Findings

                  • Imaging Recommendations

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • General Features

                        • Staging, Grading, & Classification

                          • Gross Pathologic & Surgical Features

                            • Microscopic Features

                              CLINICAL ISSUES

                              • Presentation

                                • Demographics

                                  • Natural History & Prognosis

                                    • Treatment

                                      DIAGNOSTIC CHECKLIST

                                      • Consider

                                        • Image Interpretation Pearls

                                          Selected References

                                          1. Luciano DE et al: Contrast Ultrasonography for Tubal Patency. J Minim Invasive Gynecol. Epub ahead of print, 2014
                                          2. Panchal S et al: Imaging techniques for assessment of tubal status. J Hum Reprod Sci. 7(1):2-12, 2014
                                          3. Mabrouk M et al: Do women with deep infiltrating endometriosis have more tubal alterations? Objective evaluation of 473 patients. J Reprod Med. 58(9-10):417-24, 2013
                                          4. Maheux-Lacroix S et al: Hysterosalpingosonography for diagnosing tubal occlusion in subfertile women: a systematic review protocol. Syst Rev. 2:50, 2013
                                          5. Yaranal PJ et al: Salpingitis isthmica nodosa: a case report. J Clin Diagn Res. 7(11):2581-2, 2013
                                          6. Ma L et al: Fallopian tubal patency diagnosed by magnetic resonance hysterosalpingography. J Reprod Med. 57(9-10):435-40, 2012
                                          7. Schippert C et al: The risk of ectopic pregnancy following tubal reconstructive microsurgery and assisted reproductive technology procedures. Arch Gynecol Obstet. 285(3):863-71, 2012
                                          8. Rezvani M et al: Fallopian tube disease in the nonpregnant patient. Radiographics. 31(2):527-48, 2011
                                          9. Allahbadia GN et al: Fallopian tube recanalization: lessons learnt and future challenges. Womens Health (Lond Engl). 6(4):531-48, quiz 548-9, 2010
                                          10. Chawla N et al: Salpingitis isthmica nodosa. Indian J Pathol Microbiol. 52(3):434-5, 2009
                                          11. Steinkeler JA et al: Female infertility: a systematic approach to radiologic imaging and diagnosis. Radiographics. 29(5):1353-70, 2009
                                          12. Eng CW et al: Hysterosalpingography: current applications. Singapore Med J. 48(4):368-73; quiz 374, 2007
                                          13. Simpson WL Jr et al: Hysterosalpingography: a reemerging study. Radiographics. 26(2):419-31, 2006
                                          14. Almeida OD Jr: Microlaparoscopy and a GnRH agonist: a combined minimally invasive approach for the diagnosis and treatment of occlusive salpingitis isthmica nodosa associated with endometriosis. JSLS. 9(4):431-3, 2005
                                          15. Awartani K et al: Microsurgical resection of nonocclusive salpingitis isthmica nodosa is beneficial. Fertil Steril. 79(5):1199-203, 2003
                                          16. Houston JG et al: Salpingitis isthmica nodosa: technical success and outcome of fluoroscopic transcervical fallopian tube recanalization. Cardiovasc Intervent Radiol. 21(1):31-5, 1998
                                          17. Lang EK et al: Recanalization of obstructed fallopian tube by selective salpingography and transvaginal bougie dilatation: outcome and cost analysis. Fertil Steril. 66(2):210-5, 1996
                                          18. Thurmond AS et al: Salpingitis isthmica nodosa: results of transcervical fluoroscopic catheter recanalization. Fertil Steril. 63(4):715-22, 1995
                                          19. Gurgan T et al: Salpingoscopic findings in women with occlusive and nonocclusive salpingitis isthmica nodosa. Fertil Steril. 61(3):461-3, 1994
                                          20. Kutluay L et al: Tubal histopathology in ectopic pregnancies. Eur J Obstet Gynecol Reprod Biol. 57(2):91-4, 1994
                                          21. Saracoglu FO et al: Salpingitis isthmica nodosa in infertility and ectopic pregnancy. Gynecol Obstet Invest. 34(4):202-5, 1992
                                          22. Skibsted L et al: Salpingitis isthmica nodosa in female infertility and tubal diseases. Hum Reprod. 6(6):828-31, 1991
                                          23. Stock RJ: Histopathology of fallopian tubes with recurrent tubal pregnancy. Obstet Gynecol. 75(1):9-14, 1990
                                          24. McComb PF et al: Salpingitis isthmica nodosa: evidence it is a progressive disease. Fertil Steril. 51(3):542-5, 1989
                                          25. Creasy JL et al: Salpingitis isthmica nodosa: radiologic and clinical correlates. Radiology. 154(3):597-600, 1985
                                          Related Anatomy
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                                          Related Differential Diagnoses
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                                          References
                                          Tables

                                          Tables

                                          KEY FACTS

                                          • Imaging

                                            • Top Differential Diagnoses

                                              • Pathology

                                                • Clinical Issues

                                                  TERMINOLOGY

                                                  • Abbreviations

                                                    • Salpingitis isthmica nodosa (SIN)
                                                  • Synonyms

                                                    • Tubal diverticulosis
                                                    • Tubal adenomyosis
                                                  • Definitions

                                                    • Small outpouchings or diverticula from isthmic portion of fallopian tube

                                                  IMAGING

                                                  • General Features

                                                    • Hysterosalpingography (HSG)

                                                      • MR Findings

                                                        • Ultrasonographic Findings

                                                          • Imaging Recommendations

                                                            DIFFERENTIAL DIAGNOSIS

                                                              PATHOLOGY

                                                              • General Features

                                                                • Staging, Grading, & Classification

                                                                  • Gross Pathologic & Surgical Features

                                                                    • Microscopic Features

                                                                      CLINICAL ISSUES

                                                                      • Presentation

                                                                        • Demographics

                                                                          • Natural History & Prognosis

                                                                            • Treatment

                                                                              DIAGNOSTIC CHECKLIST

                                                                              • Consider

                                                                                • Image Interpretation Pearls

                                                                                  Selected References

                                                                                  1. Luciano DE et al: Contrast Ultrasonography for Tubal Patency. J Minim Invasive Gynecol. Epub ahead of print, 2014
                                                                                  2. Panchal S et al: Imaging techniques for assessment of tubal status. J Hum Reprod Sci. 7(1):2-12, 2014
                                                                                  3. Mabrouk M et al: Do women with deep infiltrating endometriosis have more tubal alterations? Objective evaluation of 473 patients. J Reprod Med. 58(9-10):417-24, 2013
                                                                                  4. Maheux-Lacroix S et al: Hysterosalpingosonography for diagnosing tubal occlusion in subfertile women: a systematic review protocol. Syst Rev. 2:50, 2013
                                                                                  5. Yaranal PJ et al: Salpingitis isthmica nodosa: a case report. J Clin Diagn Res. 7(11):2581-2, 2013
                                                                                  6. Ma L et al: Fallopian tubal patency diagnosed by magnetic resonance hysterosalpingography. J Reprod Med. 57(9-10):435-40, 2012
                                                                                  7. Schippert C et al: The risk of ectopic pregnancy following tubal reconstructive microsurgery and assisted reproductive technology procedures. Arch Gynecol Obstet. 285(3):863-71, 2012
                                                                                  8. Rezvani M et al: Fallopian tube disease in the nonpregnant patient. Radiographics. 31(2):527-48, 2011
                                                                                  9. Allahbadia GN et al: Fallopian tube recanalization: lessons learnt and future challenges. Womens Health (Lond Engl). 6(4):531-48, quiz 548-9, 2010
                                                                                  10. Chawla N et al: Salpingitis isthmica nodosa. Indian J Pathol Microbiol. 52(3):434-5, 2009
                                                                                  11. Steinkeler JA et al: Female infertility: a systematic approach to radiologic imaging and diagnosis. Radiographics. 29(5):1353-70, 2009
                                                                                  12. Eng CW et al: Hysterosalpingography: current applications. Singapore Med J. 48(4):368-73; quiz 374, 2007
                                                                                  13. Simpson WL Jr et al: Hysterosalpingography: a reemerging study. Radiographics. 26(2):419-31, 2006
                                                                                  14. Almeida OD Jr: Microlaparoscopy and a GnRH agonist: a combined minimally invasive approach for the diagnosis and treatment of occlusive salpingitis isthmica nodosa associated with endometriosis. JSLS. 9(4):431-3, 2005
                                                                                  15. Awartani K et al: Microsurgical resection of nonocclusive salpingitis isthmica nodosa is beneficial. Fertil Steril. 79(5):1199-203, 2003
                                                                                  16. Houston JG et al: Salpingitis isthmica nodosa: technical success and outcome of fluoroscopic transcervical fallopian tube recanalization. Cardiovasc Intervent Radiol. 21(1):31-5, 1998
                                                                                  17. Lang EK et al: Recanalization of obstructed fallopian tube by selective salpingography and transvaginal bougie dilatation: outcome and cost analysis. Fertil Steril. 66(2):210-5, 1996
                                                                                  18. Thurmond AS et al: Salpingitis isthmica nodosa: results of transcervical fluoroscopic catheter recanalization. Fertil Steril. 63(4):715-22, 1995
                                                                                  19. Gurgan T et al: Salpingoscopic findings in women with occlusive and nonocclusive salpingitis isthmica nodosa. Fertil Steril. 61(3):461-3, 1994
                                                                                  20. Kutluay L et al: Tubal histopathology in ectopic pregnancies. Eur J Obstet Gynecol Reprod Biol. 57(2):91-4, 1994
                                                                                  21. Saracoglu FO et al: Salpingitis isthmica nodosa in infertility and ectopic pregnancy. Gynecol Obstet Invest. 34(4):202-5, 1992
                                                                                  22. Skibsted L et al: Salpingitis isthmica nodosa in female infertility and tubal diseases. Hum Reprod. 6(6):828-31, 1991
                                                                                  23. Stock RJ: Histopathology of fallopian tubes with recurrent tubal pregnancy. Obstet Gynecol. 75(1):9-14, 1990
                                                                                  24. McComb PF et al: Salpingitis isthmica nodosa: evidence it is a progressive disease. Fertil Steril. 51(3):542-5, 1989
                                                                                  25. Creasy JL et al: Salpingitis isthmica nodosa: radiologic and clinical correlates. Radiology. 154(3):597-600, 1985