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Sarcoidosis: Bone
Sandra Moore, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Clinical Issues

        • Diagnostic Checklist

          TERMINOLOGY

          • Definitions

            • Inflammatory disorder of unknown cause resulting in noncaseating granulomatous deposits in tissues
              • Lungs/lymph nodes most frequently affected
              • Wide variety of musculoskeletal manifestations
                • Bone, muscle, joint, soft tissue; bone discussed in this section

          IMAGING

          • General Features

            • Imaging Recommendations

              • Radiographic Findings

                • CT Findings

                  • MR Findings

                    • Nuclear Medicine Findings

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Staging, Grading, & Classification

                            • Gross Pathologic & Surgical Features

                              • Microscopic Features

                                CLINICAL ISSUES

                                • Presentation

                                  • Demographics

                                    • Natural History & Prognosis

                                      • Treatment

                                        DIAGNOSTIC CHECKLIST

                                        • Consider

                                          Selected References

                                          1. Lew PP et al: Imaging of disorders affecting the bone and skin. Radiographics. 34(1):197-216, 2014
                                          2. Vardhanabhuti V et al: Sarcoidosis--the greatest mimic. Semin Ultrasound CT MR. 35(3):215-24, 2014
                                          3. Moore SL et al: Can sarcoidosis and metastatic bone lesions be reliably differentiated on routine MRI? AJR Am J Roentgenol. 198(6):1387-93, 2012
                                          4. Baldini S et al: PET positivity with bone marrow biopsy revealing sarcoidosis in a patient in whom bone marrow metastases had been suspected. Br J Haematol. 143(3):306, 2008
                                          5. Simpfendorfer CS et al: Does the presence of focal normal marrow fat signal within a tumor on MRI exclude malignancy? An analysis of 184 histologically proven tumors of the pelvic and appendicular skeleton. Skeletal Radiol. 37(9):797-804, 2008
                                          6. Talmi D et al: Central skeletal sarcoidosis mimicking metastatic disease. Skeletal Radiol. 37(8):757-61, 2008
                                          7. Thelier N et al: Osteoarticular involvement in a series of 100 patients with sarcoidosis referred to rheumatology departments. J Rheumatol. 35(8):1622-8, 2008
                                          8. Iannuzzi MC et al: Sarcoidosis. N Engl J Med. 357(21):2153-65, 2007
                                          9. Moore SL et al: MRI of sarcoidosis patients with musculoskeletal symptoms. AJR Am J Roentgenol. 185(1):154-9, 2005
                                          10. Aberg C et al: FDG positron emission tomography of bone involvement in sarcoidosis. AJR Am J Roentgenol. 182(4):975-7, 2004
                                          11. Moore SL et al: Musculoskeletal sarcoidosis: spectrum of appearances at MR imaging. Radiographics. 23(6):1389-99, 2003
                                          Related Anatomy
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                                          Related Differential Diagnoses
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                                          References
                                          Tables

                                          Tables

                                          KEY FACTS

                                          • Terminology

                                            • Imaging

                                              • Clinical Issues

                                                • Diagnostic Checklist

                                                  TERMINOLOGY

                                                  • Definitions

                                                    • Inflammatory disorder of unknown cause resulting in noncaseating granulomatous deposits in tissues
                                                      • Lungs/lymph nodes most frequently affected
                                                      • Wide variety of musculoskeletal manifestations
                                                        • Bone, muscle, joint, soft tissue; bone discussed in this section

                                                  IMAGING

                                                  • General Features

                                                    • Imaging Recommendations

                                                      • Radiographic Findings

                                                        • CT Findings

                                                          • MR Findings

                                                            • Nuclear Medicine Findings

                                                              DIFFERENTIAL DIAGNOSIS

                                                                PATHOLOGY

                                                                • General Features

                                                                  • Staging, Grading, & Classification

                                                                    • Gross Pathologic & Surgical Features

                                                                      • Microscopic Features

                                                                        CLINICAL ISSUES

                                                                        • Presentation

                                                                          • Demographics

                                                                            • Natural History & Prognosis

                                                                              • Treatment

                                                                                DIAGNOSTIC CHECKLIST

                                                                                • Consider

                                                                                  Selected References

                                                                                  1. Lew PP et al: Imaging of disorders affecting the bone and skin. Radiographics. 34(1):197-216, 2014
                                                                                  2. Vardhanabhuti V et al: Sarcoidosis--the greatest mimic. Semin Ultrasound CT MR. 35(3):215-24, 2014
                                                                                  3. Moore SL et al: Can sarcoidosis and metastatic bone lesions be reliably differentiated on routine MRI? AJR Am J Roentgenol. 198(6):1387-93, 2012
                                                                                  4. Baldini S et al: PET positivity with bone marrow biopsy revealing sarcoidosis in a patient in whom bone marrow metastases had been suspected. Br J Haematol. 143(3):306, 2008
                                                                                  5. Simpfendorfer CS et al: Does the presence of focal normal marrow fat signal within a tumor on MRI exclude malignancy? An analysis of 184 histologically proven tumors of the pelvic and appendicular skeleton. Skeletal Radiol. 37(9):797-804, 2008
                                                                                  6. Talmi D et al: Central skeletal sarcoidosis mimicking metastatic disease. Skeletal Radiol. 37(8):757-61, 2008
                                                                                  7. Thelier N et al: Osteoarticular involvement in a series of 100 patients with sarcoidosis referred to rheumatology departments. J Rheumatol. 35(8):1622-8, 2008
                                                                                  8. Iannuzzi MC et al: Sarcoidosis. N Engl J Med. 357(21):2153-65, 2007
                                                                                  9. Moore SL et al: MRI of sarcoidosis patients with musculoskeletal symptoms. AJR Am J Roentgenol. 185(1):154-9, 2005
                                                                                  10. Aberg C et al: FDG positron emission tomography of bone involvement in sarcoidosis. AJR Am J Roentgenol. 182(4):975-7, 2004
                                                                                  11. Moore SL et al: Musculoskeletal sarcoidosis: spectrum of appearances at MR imaging. Radiographics. 23(6):1389-99, 2003