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Sarcoidosis Lymph Nodes
Nicholas A. Koontz, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Definitions

                • Noncaseating granulomatous inflammatory disease of unknown etiology

              IMAGING

              • General Features

                • Imaging Recommendations

                  • CT Findings

                    • MR Findings

                      • Nuclear Medicine Findings

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Gross Pathologic & Surgical Features

                              • Microscopic Features

                                CLINICAL ISSUES

                                • Presentation

                                  • Demographics

                                    • Natural History & Prognosis

                                      • Treatment

                                        DIAGNOSTIC CHECKLIST

                                        • Consider

                                          Selected References

                                          1. Flyger TF et al: Granulomatous inflammation in lymph nodes of the head and neck-a retrospective analysis of causes in a population with very low incidence of tuberculosis. Immunol Res. 68(4):198-203, 2020
                                          2. Send T et al: Clinical features of sarcoidosis patients presenting with head and neck manifestations - a two-center retrospective study and proposal of a diagnostic algorithm for the otorhinolaryngologist. Acta Otolaryngol. 140(2):144-8, 2020
                                          3. Welter SM et al: Histologic review of sarcoidosis in a neck lymph node. Head Neck Pathol. 12(2):255-8, 2018
                                          4. Białek EJ et al: Mistakes in ultrasound diagnosis of superficial lymph nodes. J Ultrason. 17(68):59-65, 2017
                                          5. Eisenmenger LB et al: Imaging of head and neck lymph nodes. Radiol Clin North Am. 53(1):115-32, 2015
                                          6. *Holzapfel K et al: Value of diffusion-weighted MR imaging in the differentiation between benign and malignant cervical lymph nodes. Eur J Radiol. 72(3):381-7, 2008
                                          7. Iannuzzi MC et al: Sarcoidosis. N Engl J Med. 357(21):2153-65, 2007
                                          8. Li YJ et al: Cervical and axillary lymph node sarcoidosis misdiagnosed as lymphoma on F-18 FDG PET-CT. Clin Nucl Med. 32(3):262-4, 2007
                                          9. Teirstein AS et al: Results of 188 whole-body fluorodeoxyglucose positron emission tomography scans in 137 patients with sarcoidosis. Chest. 132(6):1949-53, 2007
                                          10. Saussez S et al: Clinically unsuspected tonsillar sarcoidosis in a child revealed by routine histologic examination. Int J Pediatr Otorhinolaryngol. 70(1):155-8, 2006
                                          11. Porter N et al: Endocrine and reproductive manifestations of sarcoidosis. QJM. 96(8):553-61, 2003
                                          12. Joe A et al: Cervical lymph node sarcoidosis as a pitfall in F-18 FDG positron emission tomography. Clin Nucl Med. 26(6):542-3, 2001
                                          13. Onishi Y et al: Systemic sarcoidosis with significant granulomatous swelling of the pharyngeal tonsil. Intern Med. 37(2):157-60, 1998
                                          14. Kaji AV et al: Imaging of cervical lymphadenopathy. Semin Ultrasound CT MR. 18(3):220-49, 1997
                                          15. Schroder KE et al: Granulomatos cervical lymphadenitis. J Otolaryngol. 8(2):127-31, 1979
                                          Related Anatomy
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                                          Related Differential Diagnoses
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                                          References
                                          Tables

                                          Tables

                                          KEY FACTS

                                          • Terminology

                                            • Imaging

                                              • Top Differential Diagnoses

                                                • Pathology

                                                  • Clinical Issues

                                                    • Diagnostic Checklist

                                                      TERMINOLOGY

                                                      • Definitions

                                                        • Noncaseating granulomatous inflammatory disease of unknown etiology

                                                      IMAGING

                                                      • General Features

                                                        • Imaging Recommendations

                                                          • CT Findings

                                                            • MR Findings

                                                              • Nuclear Medicine Findings

                                                                DIFFERENTIAL DIAGNOSIS

                                                                  PATHOLOGY

                                                                  • General Features

                                                                    • Gross Pathologic & Surgical Features

                                                                      • Microscopic Features

                                                                        CLINICAL ISSUES

                                                                        • Presentation

                                                                          • Demographics

                                                                            • Natural History & Prognosis

                                                                              • Treatment

                                                                                DIAGNOSTIC CHECKLIST

                                                                                • Consider

                                                                                  Selected References

                                                                                  1. Flyger TF et al: Granulomatous inflammation in lymph nodes of the head and neck-a retrospective analysis of causes in a population with very low incidence of tuberculosis. Immunol Res. 68(4):198-203, 2020
                                                                                  2. Send T et al: Clinical features of sarcoidosis patients presenting with head and neck manifestations - a two-center retrospective study and proposal of a diagnostic algorithm for the otorhinolaryngologist. Acta Otolaryngol. 140(2):144-8, 2020
                                                                                  3. Welter SM et al: Histologic review of sarcoidosis in a neck lymph node. Head Neck Pathol. 12(2):255-8, 2018
                                                                                  4. Białek EJ et al: Mistakes in ultrasound diagnosis of superficial lymph nodes. J Ultrason. 17(68):59-65, 2017
                                                                                  5. Eisenmenger LB et al: Imaging of head and neck lymph nodes. Radiol Clin North Am. 53(1):115-32, 2015
                                                                                  6. *Holzapfel K et al: Value of diffusion-weighted MR imaging in the differentiation between benign and malignant cervical lymph nodes. Eur J Radiol. 72(3):381-7, 2008
                                                                                  7. Iannuzzi MC et al: Sarcoidosis. N Engl J Med. 357(21):2153-65, 2007
                                                                                  8. Li YJ et al: Cervical and axillary lymph node sarcoidosis misdiagnosed as lymphoma on F-18 FDG PET-CT. Clin Nucl Med. 32(3):262-4, 2007
                                                                                  9. Teirstein AS et al: Results of 188 whole-body fluorodeoxyglucose positron emission tomography scans in 137 patients with sarcoidosis. Chest. 132(6):1949-53, 2007
                                                                                  10. Saussez S et al: Clinically unsuspected tonsillar sarcoidosis in a child revealed by routine histologic examination. Int J Pediatr Otorhinolaryngol. 70(1):155-8, 2006
                                                                                  11. Porter N et al: Endocrine and reproductive manifestations of sarcoidosis. QJM. 96(8):553-61, 2003
                                                                                  12. Joe A et al: Cervical lymph node sarcoidosis as a pitfall in F-18 FDG positron emission tomography. Clin Nucl Med. 26(6):542-3, 2001
                                                                                  13. Onishi Y et al: Systemic sarcoidosis with significant granulomatous swelling of the pharyngeal tonsil. Intern Med. 37(2):157-60, 1998
                                                                                  14. Kaji AV et al: Imaging of cervical lymphadenopathy. Semin Ultrasound CT MR. 18(3):220-49, 1997
                                                                                  15. Schroder KE et al: Granulomatos cervical lymphadenitis. J Otolaryngol. 8(2):127-31, 1979