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Sarcoidosis of Joint
Donna G. Blankenbaker, MD, FACR; Sandra Moore, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          TERMINOLOGY

          • Definitions

            • Sarcoidosis arthropathy has 2 principal manifestations: acute (resolving/remitting) and chronic (transient/relapsing)
              • Acute sarcoidosis arthropathy
                • Usually is self-limiting, remitting in 4-6 weeks
                • Löfgren syndrome is variant of acute sarcoidosis arthropathy
                  • Remitting oligoarthropathy
                  • Manifests early in course of sarcoidosis
                  • Arthralgias (often bilateral ankles), erythema nodosum, bilateral hilar lymphadenopathy
                • Disease clusters are seen in spring/early summer
              • Chronic relapsing sarcoidosis arthropathy
                • Observed ≥ 6 months following diagnosis of sarcoidosis
                • Disease may wax and wane

          IMAGING

          • General Features

            • Radiographic Findings

              • MR Findings

                • Imaging Recommendations

                  DIFFERENTIAL DIAGNOSIS

                    PATHOLOGY

                    • General Features

                      • Gross Pathologic & Surgical Features

                        CLINICAL ISSUES

                        • Presentation

                          • Demographics

                            • Natural History & Prognosis

                              • Treatment

                                Selected References

                                1. Patil S et al: Musculoskeletal sarcoidosis: a single center experience over 15 years. Int J Rheum Dis. 24(4):533-41, 2021
                                2. Papiris SA et al: Prevalence, distribution and clinical significance of joints, muscles and bones in sarcoidosis: an 18F-FDG-PET/CT study. Expert Rev Respir Med. 14(9):957-64, 2020
                                3. Akaike G et al: PET/CT in the diagnosis and workup of sarcoidosis: Focus on atypical manifestations. Radiographics. 38(5):1536-49, 2018
                                4. Bechman K et al: A review of the musculoskeletal manifestations of sarcoidosis. Rheumatology (Oxford). 57(5):777-83, 2018
                                5. Ganeshan D et al: Sarcoidosis from head to toe: what the radiologist needs to know. Radiographics. 38(4):1180-200, 2018
                                6. Sweeney A et al: Fulminant musculoskeletal and neurologic sarcoidosis: case report and literature update. Skeletal Radiol. 45(11):1571-6, 2016
                                7. Lew PP et al: Imaging of disorders affecting the bone and skin. Radiographics. 34(1):197-216, 2014
                                8. Chatham W: Rheumatic manifestations of systemic disease: sarcoidosis. Curr Opin Rheumatol. 22(1):85-90, 2010
                                9. Torralba KD et al: Sarcoidosis and the rheumatologist. Curr Opin Rheumatol. 21(1):62-70, 2009
                                10. Moore SL et al: MRI of sarcoidosis patients with musculoskeletal symptoms. AJR Am J Roentgenol. 185(1):154-9, 2005
                                11. Abril A et al: Rheumatologic manifestations of sarcoidosis. Curr Opin Rheumatol. 16(1):51-5, 2004
                                12. Moore SL et al: Musculoskeletal sarcoidosis: spectrum of appearances at MR imaging. Radiographics. 23(6):1389-99, 2003
                                13. Pettersson T: Rheumatic features of sarcoidosis. Curr Opin Rheumatol. 10(1):73-8, 1998
                                Related Anatomy
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                                Related Differential Diagnoses
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                                References
                                Tables

                                Tables

                                KEY FACTS

                                • Terminology

                                  • Imaging

                                    • Top Differential Diagnoses

                                      • Clinical Issues

                                        TERMINOLOGY

                                        • Definitions

                                          • Sarcoidosis arthropathy has 2 principal manifestations: acute (resolving/remitting) and chronic (transient/relapsing)
                                            • Acute sarcoidosis arthropathy
                                              • Usually is self-limiting, remitting in 4-6 weeks
                                              • Löfgren syndrome is variant of acute sarcoidosis arthropathy
                                                • Remitting oligoarthropathy
                                                • Manifests early in course of sarcoidosis
                                                • Arthralgias (often bilateral ankles), erythema nodosum, bilateral hilar lymphadenopathy
                                              • Disease clusters are seen in spring/early summer
                                            • Chronic relapsing sarcoidosis arthropathy
                                              • Observed ≥ 6 months following diagnosis of sarcoidosis
                                              • Disease may wax and wane

                                        IMAGING

                                        • General Features

                                          • Radiographic Findings

                                            • MR Findings

                                              • Imaging Recommendations

                                                DIFFERENTIAL DIAGNOSIS

                                                  PATHOLOGY

                                                  • General Features

                                                    • Gross Pathologic & Surgical Features

                                                      CLINICAL ISSUES

                                                      • Presentation

                                                        • Demographics

                                                          • Natural History & Prognosis

                                                            • Treatment

                                                              Selected References

                                                              1. Patil S et al: Musculoskeletal sarcoidosis: a single center experience over 15 years. Int J Rheum Dis. 24(4):533-41, 2021
                                                              2. Papiris SA et al: Prevalence, distribution and clinical significance of joints, muscles and bones in sarcoidosis: an 18F-FDG-PET/CT study. Expert Rev Respir Med. 14(9):957-64, 2020
                                                              3. Akaike G et al: PET/CT in the diagnosis and workup of sarcoidosis: Focus on atypical manifestations. Radiographics. 38(5):1536-49, 2018
                                                              4. Bechman K et al: A review of the musculoskeletal manifestations of sarcoidosis. Rheumatology (Oxford). 57(5):777-83, 2018
                                                              5. Ganeshan D et al: Sarcoidosis from head to toe: what the radiologist needs to know. Radiographics. 38(4):1180-200, 2018
                                                              6. Sweeney A et al: Fulminant musculoskeletal and neurologic sarcoidosis: case report and literature update. Skeletal Radiol. 45(11):1571-6, 2016
                                                              7. Lew PP et al: Imaging of disorders affecting the bone and skin. Radiographics. 34(1):197-216, 2014
                                                              8. Chatham W: Rheumatic manifestations of systemic disease: sarcoidosis. Curr Opin Rheumatol. 22(1):85-90, 2010
                                                              9. Torralba KD et al: Sarcoidosis and the rheumatologist. Curr Opin Rheumatol. 21(1):62-70, 2009
                                                              10. Moore SL et al: MRI of sarcoidosis patients with musculoskeletal symptoms. AJR Am J Roentgenol. 185(1):154-9, 2005
                                                              11. Abril A et al: Rheumatologic manifestations of sarcoidosis. Curr Opin Rheumatol. 16(1):51-5, 2004
                                                              12. Moore SL et al: Musculoskeletal sarcoidosis: spectrum of appearances at MR imaging. Radiographics. 23(6):1389-99, 2003
                                                              13. Pettersson T: Rheumatic features of sarcoidosis. Curr Opin Rheumatol. 10(1):73-8, 1998