link
Bookmarks
Sarcomas
Nathaniel Garrett Gray, MD; Paige Bennett, MD
To access 4,300 diagnoses written by the world's leading experts in radiology, please log in or subscribe.Log inSubscribe
1
0
0
0

KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Definitions

              • Sarcomas: Diverse group of primary malignant tumors of mesenchymal origin
              • Classified by tissue subtype
                • Adipocytic
                • Fibroblastic/myofibroblastic
                • Fibrohistiocytic
                • Smooth muscle
                • Skeletal muscle
                • Vascular
                • Chondroosseous
                • Tumors of uncertain differentiation
              • Most common in adults: Liposarcoma, leiomyosarcoma, and undifferentiated pleomorphic sarcoma
              • Most common in pediatrics: Rhabdomyosarcoma
              • Location
                • Extremities (75%): Most located in thigh
                • Trunk: Wall (10%) and retroperitoneum (10%)

            IMAGING

            • F-18 FDG PET/CT Findings

              • CT Findings

                • MR Findings

                  • Ultrasound Findings

                    • Imaging Recommendations

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Staging, Grading, & Classification

                            CLINICAL ISSUES

                            • Presentation

                              • Demographics

                                • Natural History & Prognosis

                                  • Treatment

                                    DIAGNOSTIC CHECKLIST

                                    • Consider

                                      Selected References

                                      1. Kiratli PÖ et al: Nuclear medicine in pediatric and adolescent tumors. Semin Nucl Med. 46(4):308-23, 2016
                                      2. Rakheja R et al: Correlating metabolic activity on 18F-FDG PET/CT with histopathologic characteristics of osseous and soft-tissue sarcomas: a retrospective review of 136 patients. AJR Am J Roentgenol. 198(6):1409-16, 2012
                                      3. Eary JF et al: Spatial heterogeneity in sarcoma 18F-FDG uptake as a predictor of patient outcome. J Nucl Med. 49(12):1973-9, 2008
                                      4. Robinson E et al: Oncodiagnosis panel: 2007: multidisciplinary management of soft-tissue sarcoma. Radiographics. 28(7):2069-86, 2008
                                      5. Schuetze SM et al: Selection of response criteria for clinical trials of sarcoma treatment. Oncologist. 13 Suppl 2:32-40, 2008
                                      6. Tzeng CW et al: Soft tissue sarcoma: preoperative and postoperative imaging for staging. Surg Oncol Clin N Am. 16(2):389-402, 2007
                                      Related Anatomy
                                      Loading...
                                      Related Differential Diagnoses
                                      Loading...
                                      References
                                      Tables

                                      Tables

                                      KEY FACTS

                                      • Terminology

                                        • Imaging

                                          • Top Differential Diagnoses

                                            • Pathology

                                              • Clinical Issues

                                                TERMINOLOGY

                                                • Definitions

                                                  • Sarcomas: Diverse group of primary malignant tumors of mesenchymal origin
                                                  • Classified by tissue subtype
                                                    • Adipocytic
                                                    • Fibroblastic/myofibroblastic
                                                    • Fibrohistiocytic
                                                    • Smooth muscle
                                                    • Skeletal muscle
                                                    • Vascular
                                                    • Chondroosseous
                                                    • Tumors of uncertain differentiation
                                                  • Most common in adults: Liposarcoma, leiomyosarcoma, and undifferentiated pleomorphic sarcoma
                                                  • Most common in pediatrics: Rhabdomyosarcoma
                                                  • Location
                                                    • Extremities (75%): Most located in thigh
                                                    • Trunk: Wall (10%) and retroperitoneum (10%)

                                                IMAGING

                                                • F-18 FDG PET/CT Findings

                                                  • CT Findings

                                                    • MR Findings

                                                      • Ultrasound Findings

                                                        • Imaging Recommendations

                                                          DIFFERENTIAL DIAGNOSIS

                                                            PATHOLOGY

                                                            • General Features

                                                              • Staging, Grading, & Classification

                                                                CLINICAL ISSUES

                                                                • Presentation

                                                                  • Demographics

                                                                    • Natural History & Prognosis

                                                                      • Treatment

                                                                        DIAGNOSTIC CHECKLIST

                                                                        • Consider

                                                                          Selected References

                                                                          1. Kiratli PÖ et al: Nuclear medicine in pediatric and adolescent tumors. Semin Nucl Med. 46(4):308-23, 2016
                                                                          2. Rakheja R et al: Correlating metabolic activity on 18F-FDG PET/CT with histopathologic characteristics of osseous and soft-tissue sarcomas: a retrospective review of 136 patients. AJR Am J Roentgenol. 198(6):1409-16, 2012
                                                                          3. Eary JF et al: Spatial heterogeneity in sarcoma 18F-FDG uptake as a predictor of patient outcome. J Nucl Med. 49(12):1973-9, 2008
                                                                          4. Robinson E et al: Oncodiagnosis panel: 2007: multidisciplinary management of soft-tissue sarcoma. Radiographics. 28(7):2069-86, 2008
                                                                          5. Schuetze SM et al: Selection of response criteria for clinical trials of sarcoma treatment. Oncologist. 13 Suppl 2:32-40, 2008
                                                                          6. Tzeng CW et al: Soft tissue sarcoma: preoperative and postoperative imaging for staging. Surg Oncol Clin N Am. 16(2):389-402, 2007