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Second Impact Syndrome
Anne G. Osborn, MD, FACR
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Abbreviations

              • Second impact syndrome (SIS)
            • Synonyms

              • Dysautoregulation
            • Definitions

              • Repeated head trauma within "window of vulnerability" before brain recovers from initial concussive injury
              • Can result in catastrophic brain swelling with permanent disability or death

            IMAGING

            • General Features

              • CT Findings

                • MR Findings

                  • Imaging Recommendations

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • General Features

                        • Gross Pathologic & Surgical Features

                          CLINICAL ISSUES

                          • Presentation

                            • Demographics

                              • Natural History & Prognosis

                                Selected References

                                1. McKee AC et al: The neuropathology of sport. Acta Neuropathol. 127(1):29-51, 2014
                                2. Harmon KG et al: American Medical Society for Sports Medicine position statement: concussion in sport. Br J Sports Med. 47(1):15-26, 2013
                                3. Weinstein E et al: Second impact syndrome in football: new imaging and insights into a rare and devastating condition. J Neurosurg Pediatr. 11(3):331-4, 2013
                                4. Cantu RC et al: Second-impact syndrome and a small subdural hematoma: an uncommon catastrophic result of repetitive head injury with a characteristic imaging appearance. J Neurotrauma. 27(9):1557-64, 2010
                                5. Wetjen NM et al: Second impact syndrome: concussion and second injury brain complications. J Am Coll Surg. 211(4):553-7, 2010
                                Related Anatomy
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                                Related Differential Diagnoses
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                                References
                                Tables

                                Tables

                                KEY FACTS

                                • Terminology

                                  • Imaging

                                    • Top Differential Diagnoses

                                      • Pathology

                                        • Clinical Issues

                                          TERMINOLOGY

                                          • Abbreviations

                                            • Second impact syndrome (SIS)
                                          • Synonyms

                                            • Dysautoregulation
                                          • Definitions

                                            • Repeated head trauma within "window of vulnerability" before brain recovers from initial concussive injury
                                            • Can result in catastrophic brain swelling with permanent disability or death

                                          IMAGING

                                          • General Features

                                            • CT Findings

                                              • MR Findings

                                                • Imaging Recommendations

                                                  DIFFERENTIAL DIAGNOSIS

                                                    PATHOLOGY

                                                    • General Features

                                                      • Gross Pathologic & Surgical Features

                                                        CLINICAL ISSUES

                                                        • Presentation

                                                          • Demographics

                                                            • Natural History & Prognosis

                                                              Selected References

                                                              1. McKee AC et al: The neuropathology of sport. Acta Neuropathol. 127(1):29-51, 2014
                                                              2. Harmon KG et al: American Medical Society for Sports Medicine position statement: concussion in sport. Br J Sports Med. 47(1):15-26, 2013
                                                              3. Weinstein E et al: Second impact syndrome in football: new imaging and insights into a rare and devastating condition. J Neurosurg Pediatr. 11(3):331-4, 2013
                                                              4. Cantu RC et al: Second-impact syndrome and a small subdural hematoma: an uncommon catastrophic result of repetitive head injury with a characteristic imaging appearance. J Neurotrauma. 27(9):1557-64, 2010
                                                              5. Wetjen NM et al: Second impact syndrome: concussion and second injury brain complications. J Am Coll Surg. 211(4):553-7, 2010