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Secondary Osteosarcoma
Behrang Amini, MD, PhD; B. J. Manaster, MD, PhD, FACR
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KEY FACTS

  • Terminology

    • Imaging

      • Clinical Issues

        TERMINOLOGY

        • Synonyms

          • Paget sarcoma, osteosarcoma (OS) in Paget disease
          • Radiation-associated OS
        • Definitions

          • OS arising in abnormal bone
            • Paget disease
            • Previously irradiated bone
            • Bone infarction
            • Fibrous dysplasia
            • Nonspecific bone dysplasia in syndromes predisposing to OS (e.g., Rothmund-Thomson syndrome)
            • Chronic osteomyelitis
            • Bone with implant

        IMAGING

        • General Features

          • Radiographic Findings

            • CT Findings

              • MR Findings

                • Imaging Recommendations

                  DIFFERENTIAL DIAGNOSIS

                    PATHOLOGY

                    • General Features

                      • Staging, Grading, & Classification

                        • Microscopic Features

                          CLINICAL ISSUES

                          • Presentation

                            • Demographics

                              • Natural History & Prognosis

                                • Treatment

                                  DIAGNOSTIC CHECKLIST

                                  • Consider

                                    Selected References

                                    1. Flanagan AM et al: Secondary osteosarcoma. In Fletcher CDM et al: World Health Organization Classification of Tumours: Tumours of Soft Tissue and Bone. IARC Press. 419-20, 2020
                                    2. Wang Z et al: Predictors of the survival of primary and secondary older osteosarcoma patients. J Cancer. 10(19):4614-22, 2019
                                    3. Murphey MD et al: The many faces of osteosarcoma. Radiographics. 17(5):1205-31, 1997
                                    4. Kyriakos M et al: Concurrence of metaphyseal fibrous defect and osteosarcoma. Report of a case and review of the literature. Skeletal Radiol. 6(3):179-86, 1981
                                    Related Anatomy
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                                    Related Differential Diagnoses
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                                    References
                                    Tables

                                    Tables

                                    KEY FACTS

                                    • Terminology

                                      • Imaging

                                        • Clinical Issues

                                          TERMINOLOGY

                                          • Synonyms

                                            • Paget sarcoma, osteosarcoma (OS) in Paget disease
                                            • Radiation-associated OS
                                          • Definitions

                                            • OS arising in abnormal bone
                                              • Paget disease
                                              • Previously irradiated bone
                                              • Bone infarction
                                              • Fibrous dysplasia
                                              • Nonspecific bone dysplasia in syndromes predisposing to OS (e.g., Rothmund-Thomson syndrome)
                                              • Chronic osteomyelitis
                                              • Bone with implant

                                          IMAGING

                                          • General Features

                                            • Radiographic Findings

                                              • CT Findings

                                                • MR Findings

                                                  • Imaging Recommendations

                                                    DIFFERENTIAL DIAGNOSIS

                                                      PATHOLOGY

                                                      • General Features

                                                        • Staging, Grading, & Classification

                                                          • Microscopic Features

                                                            CLINICAL ISSUES

                                                            • Presentation

                                                              • Demographics

                                                                • Natural History & Prognosis

                                                                  • Treatment

                                                                    DIAGNOSTIC CHECKLIST

                                                                    • Consider

                                                                      Selected References

                                                                      1. Flanagan AM et al: Secondary osteosarcoma. In Fletcher CDM et al: World Health Organization Classification of Tumours: Tumours of Soft Tissue and Bone. IARC Press. 419-20, 2020
                                                                      2. Wang Z et al: Predictors of the survival of primary and secondary older osteosarcoma patients. J Cancer. 10(19):4614-22, 2019
                                                                      3. Murphey MD et al: The many faces of osteosarcoma. Radiographics. 17(5):1205-31, 1997
                                                                      4. Kyriakos M et al: Concurrence of metaphyseal fibrous defect and osteosarcoma. Report of a case and review of the literature. Skeletal Radiol. 6(3):179-86, 1981