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Secondary Osteosarcoma
B.J. Manaster, MD, PhD, FACR
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KEY FACTS

  • Terminology

    • Imaging

      • Clinical Issues

        TERMINOLOGY

        • Abbreviations

          • Osteosarcoma (OS)
        • Synonyms

          • Paget sarcoma
          • Radiation sarcoma, post-radiation sarcoma
          • Dedifferentiated chondrosarcoma
          • Dedifferentiated sarcoma
        • Definitions

          • Bone-forming sarcoma arising in bone affected by underlying condition making it susceptible to sarcomatous degeneration
            • Paget disease
            • Previously radiated bone
            • Dedifferentiated chondrosarcoma
            • Other rare disorders, including dedifferentiation of surface osteosarcomas (OS) to high-grade OS

        IMAGING

        • General Features

          • Radiographic Findings

            • CT Findings

              • MR Findings

                • Imaging Recommendations

                  DIFFERENTIAL DIAGNOSIS

                    PATHOLOGY

                    • General Features

                      • Staging, Grading, & Classification

                        • Microscopic Features

                          CLINICAL ISSUES

                          • Presentation

                            • Demographics

                              • Natural History & Prognosis

                                • Treatment

                                  DIAGNOSTIC CHECKLIST

                                  • Consider

                                    Selected References

                                    1. Forest M et al: Secondary osteosarcomas. In Fletcher CDM et al: World Health Organization Classification of Tumours: Tumours of Soft Tissue and Bone. Lyon: IARC Press. 277-8, 2002
                                    2. Yagishita S et al: Secondary osteosarcoma developing 10 years after chemoradiotherapy for non-small-cell lung cancer. Jpn J Clin Oncol. 44(2):191-4, 2014
                                    3. Murphey MD et al: The many faces of osteosarcoma. Radiographics. 17(5):1205-31, 1997
                                    Related Anatomy
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                                    Related Differential Diagnoses
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                                    References
                                    Tables

                                    Tables

                                    KEY FACTS

                                    • Terminology

                                      • Imaging

                                        • Clinical Issues

                                          TERMINOLOGY

                                          • Abbreviations

                                            • Osteosarcoma (OS)
                                          • Synonyms

                                            • Paget sarcoma
                                            • Radiation sarcoma, post-radiation sarcoma
                                            • Dedifferentiated chondrosarcoma
                                            • Dedifferentiated sarcoma
                                          • Definitions

                                            • Bone-forming sarcoma arising in bone affected by underlying condition making it susceptible to sarcomatous degeneration
                                              • Paget disease
                                              • Previously radiated bone
                                              • Dedifferentiated chondrosarcoma
                                              • Other rare disorders, including dedifferentiation of surface osteosarcomas (OS) to high-grade OS

                                          IMAGING

                                          • General Features

                                            • Radiographic Findings

                                              • CT Findings

                                                • MR Findings

                                                  • Imaging Recommendations

                                                    DIFFERENTIAL DIAGNOSIS

                                                      PATHOLOGY

                                                      • General Features

                                                        • Staging, Grading, & Classification

                                                          • Microscopic Features

                                                            CLINICAL ISSUES

                                                            • Presentation

                                                              • Demographics

                                                                • Natural History & Prognosis

                                                                  • Treatment

                                                                    DIAGNOSTIC CHECKLIST

                                                                    • Consider

                                                                      Selected References

                                                                      1. Forest M et al: Secondary osteosarcomas. In Fletcher CDM et al: World Health Organization Classification of Tumours: Tumours of Soft Tissue and Bone. Lyon: IARC Press. 277-8, 2002
                                                                      2. Yagishita S et al: Secondary osteosarcoma developing 10 years after chemoradiotherapy for non-small-cell lung cancer. Jpn J Clin Oncol. 44(2):191-4, 2014
                                                                      3. Murphey MD et al: The many faces of osteosarcoma. Radiographics. 17(5):1205-31, 1997