Triangular region or cone of NME, with apex pointing to nipple, suggesting duct and its branches
Suspicious for malignancy
Internal enhancement pattern of NME should also be described
Homogeneous: Confluent, uniform
Heterogeneous: Nonuniform, random, interspersed normal fibroglandular tissue and fat
Clumped: Cobblestone, various shapes and sizes, suspicious
Clustered ring: Thin rings of enhancement in periductal stroma, suspicious
IMAGING
General Features
Mammographic Findings
Ultrasonographic Findings
MR Findings
Imaging Recommendations
Nuclear Medicine Findings
Image-Guided Biopsy
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
CLINICAL ISSUES
Presentation
Demographics
Treatment
DIAGNOSTIC CHECKLIST
Image Interpretation Pearls
Reporting Tips
Selected References
Asada T et al: Grading system to categorize breast MRI using BI-RADS 5th edition: a statistical study of non-mass enhancement descriptors in terms of probability of malignancy. Jpn J Radiol. 36(3):200-8, 2018
Net JM et al: Relationships between human-extracted MRI tumor phenotypes of breast cancer and clinical prognostic indicators including receptor status and molecular subtype. Curr Probl Diagn Radiol. ePub, 2018
Santiago L et al: MR imaging-guided breast interventions: indications, key principles, and imaging-pathology correlation. Magn Reson Imaging Clin N Am. 26(2):235-46, 2018
Scott-Moncrieff A et al: MR imaging appearance of noncalcified and calcified DCIS. Breast J. 24(3):343-9, 2018
Woodard GA et al: Qualitative radiogenomics: association between oncotype DX test recurrence score and BI-RADS mammographic and breast MR imaging features. Radiology. 286(1):60-70, 2018
Chikarmane SA et al: Revisiting nonmass enhancement in breast MRI: analysis of outcomes and follow-up using the updated BI-RADS atlas. AJR Am J Roentgenol. 209(5):1178-84, 2017
Huang ML et al: Imaging-concordant benign MRI-guided vacuum-assisted breast biopsy may not warrant MRI follow-up. AJR Am J Roentgenol. 208(4):916-22, 2017
Maglione KD et al: Radiologic-pathologic correlation for benign results after MRI-guided breast biopsy. AJR Am J Roentgenol. 209(2):442-53, 2017
Navarro Vilar L et al: MR imaging findings in molecular subtypes of breast cancer according to BIRADS system. Breast J. 23(4):421-8, 2017
Taşkın F et al: Lesion characteristics, histopathologic results, and follow-up of breast lesions after MRI-guided biopsy. Diagn Interv Radiol. 23(5):333-8, 2017
Dratwa C et al: Breast MR biopsy: pathological and radiological correlation. Eur Radiol. 26(8):2510-9, 2016
Raj SD et al: Stereotactic biopsy of segmental breast calcifications: is sampling of anterior and posterior components necessary? Acad Radiol. 23(6):682-6, 2016
Shimauchi A et al: Morphology evaluation of nonmass enhancement on breast MRI: effect of a three-step interpretation model for readers' performances and biopsy recommendations. Eur J Radiol. 85(2):480-8, 2016
Chadashvili T et al: Nonmass enhancement on breast MRI: review of patterns with radiologic-pathologic correlation and discussion of management. AJR Am J Roentgenol. 204(1):219-27, 2015
Hsu HH et al: Breast nonmass enhancement detected with MRI: utility and lesion characterization with second-look ultrasonography. Breast J. 21(6):579-87, 2015
Greenwood HI et al: Ductal carcinoma in situ of the breasts: review of MR imaging features. Radiographics. 33(6):1569-88, 2013
Tozaki M. BI-RADS-MRI terminology and evaluation of intraductal carcinoma and ductal carcinoma in situ. Breast Cancer. 20:13-20, 2013
Morris EA, Comstock CE, Lee CH, et al. ACR BI-RADS magnetic resonance imaging. In: ACR BI-RADS Atlas, Breast Imaging Reporting and Data System. Reston, VA: American College of Radiology, 2013
Uematsu T et al: High-spatial-resolution 3-T breast MRI of nonmasslike enhancement lesions: an analysis of their features as significant predictors of malignancy. AJR Am J Roentgenol. 198(5):1223-30, 2012
Baltzer PA et al: Nonmass lesions in magnetic resonance imaging of the breast: additional T2-weighted images improve diagnostic accuracy. J Comput Assist Tomogr. 35(3):361-6, 2011
Narayanan D et al: Interpretation of positron emission mammography: feature analysis and rates of malignancy. AJR Am J Roentgenol. 196(4):956-70, 2011
Sohns C et al: Value of the BI-RADS classification in MR-Mammography for diagnosis of benign and malignant breast tumors. Eur Radiol. 21(12):2475-83, 2011
Mossa-Basha M et al: Ductal carcinoma in situ of the breast: MR imaging findings with histopathologic correlation. Radiographics. 30:1673-87, 2010
Yamada T et al: Radiologic-pathologic correlation of ductal carcinoma in situ. Radiographics. 30(5):1183-98, 2010
Demartini WB et al: Utility of targeted sonography for breast lesions that were suspicious on MRI. AJR Am J Roentgenol. 192(4):1128-34, 2009
Meissnitzer M et al: Targeted ultrasound of the breast in women with abnormal MRI findings for whom biopsy has been recommended. AJR Am J Roentgenol. 193(4):1025-9, 2009
Sakamoto N et al: Categorization of non-mass-like breast lesions detected by MRI. Breast Cancer. 15(3):241-6, 2008
Yuen S et al: Segmental enhancement on breast MR images: differential diagnosis and diagnostic strategy. Eur Radiol.
Tozaki M et al: High-spatial-resolution MRI of non-masslike breast lesions: interpretation model based on BI-RADS MRI descriptors. AJR Am J Roentgenol. 187(2):330-7, 2006
Morakkabati-Spitz N et al: Diagnostic usefulness of segmental and linear enhancement in dynamic breast MRI. Eur Radiol. 15(9):2010-7, 2005
Liberman L et al: Breast lesions detected on MR imaging: features and positive predictive value. AJR Am J Roentgenol. 179(1):171-8, 2002
Related Anatomy
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Related Differential Diagnoses
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Definitions
Nonmass enhancement (NME): Neither focus nor mass
Segmental: Describes NME distribution
Triangular region or cone of NME, with apex pointing to nipple, suggesting duct and its branches
Suspicious for malignancy
Internal enhancement pattern of NME should also be described
Homogeneous: Confluent, uniform
Heterogeneous: Nonuniform, random, interspersed normal fibroglandular tissue and fat
Clumped: Cobblestone, various shapes and sizes, suspicious
Clustered ring: Thin rings of enhancement in periductal stroma, suspicious
IMAGING
General Features
Mammographic Findings
Ultrasonographic Findings
MR Findings
Imaging Recommendations
Nuclear Medicine Findings
Image-Guided Biopsy
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
CLINICAL ISSUES
Presentation
Demographics
Treatment
DIAGNOSTIC CHECKLIST
Image Interpretation Pearls
Reporting Tips
Selected References
Asada T et al: Grading system to categorize breast MRI using BI-RADS 5th edition: a statistical study of non-mass enhancement descriptors in terms of probability of malignancy. Jpn J Radiol. 36(3):200-8, 2018
Net JM et al: Relationships between human-extracted MRI tumor phenotypes of breast cancer and clinical prognostic indicators including receptor status and molecular subtype. Curr Probl Diagn Radiol. ePub, 2018
Santiago L et al: MR imaging-guided breast interventions: indications, key principles, and imaging-pathology correlation. Magn Reson Imaging Clin N Am. 26(2):235-46, 2018
Scott-Moncrieff A et al: MR imaging appearance of noncalcified and calcified DCIS. Breast J. 24(3):343-9, 2018
Woodard GA et al: Qualitative radiogenomics: association between oncotype DX test recurrence score and BI-RADS mammographic and breast MR imaging features. Radiology. 286(1):60-70, 2018
Chikarmane SA et al: Revisiting nonmass enhancement in breast MRI: analysis of outcomes and follow-up using the updated BI-RADS atlas. AJR Am J Roentgenol. 209(5):1178-84, 2017
Huang ML et al: Imaging-concordant benign MRI-guided vacuum-assisted breast biopsy may not warrant MRI follow-up. AJR Am J Roentgenol. 208(4):916-22, 2017
Maglione KD et al: Radiologic-pathologic correlation for benign results after MRI-guided breast biopsy. AJR Am J Roentgenol. 209(2):442-53, 2017
Navarro Vilar L et al: MR imaging findings in molecular subtypes of breast cancer according to BIRADS system. Breast J. 23(4):421-8, 2017
Taşkın F et al: Lesion characteristics, histopathologic results, and follow-up of breast lesions after MRI-guided biopsy. Diagn Interv Radiol. 23(5):333-8, 2017
Dratwa C et al: Breast MR biopsy: pathological and radiological correlation. Eur Radiol. 26(8):2510-9, 2016
Raj SD et al: Stereotactic biopsy of segmental breast calcifications: is sampling of anterior and posterior components necessary? Acad Radiol. 23(6):682-6, 2016
Shimauchi A et al: Morphology evaluation of nonmass enhancement on breast MRI: effect of a three-step interpretation model for readers' performances and biopsy recommendations. Eur J Radiol. 85(2):480-8, 2016
Chadashvili T et al: Nonmass enhancement on breast MRI: review of patterns with radiologic-pathologic correlation and discussion of management. AJR Am J Roentgenol. 204(1):219-27, 2015
Hsu HH et al: Breast nonmass enhancement detected with MRI: utility and lesion characterization with second-look ultrasonography. Breast J. 21(6):579-87, 2015
Greenwood HI et al: Ductal carcinoma in situ of the breasts: review of MR imaging features. Radiographics. 33(6):1569-88, 2013
Tozaki M. BI-RADS-MRI terminology and evaluation of intraductal carcinoma and ductal carcinoma in situ. Breast Cancer. 20:13-20, 2013
Morris EA, Comstock CE, Lee CH, et al. ACR BI-RADS magnetic resonance imaging. In: ACR BI-RADS Atlas, Breast Imaging Reporting and Data System. Reston, VA: American College of Radiology, 2013
Uematsu T et al: High-spatial-resolution 3-T breast MRI of nonmasslike enhancement lesions: an analysis of their features as significant predictors of malignancy. AJR Am J Roentgenol. 198(5):1223-30, 2012
Baltzer PA et al: Nonmass lesions in magnetic resonance imaging of the breast: additional T2-weighted images improve diagnostic accuracy. J Comput Assist Tomogr. 35(3):361-6, 2011
Narayanan D et al: Interpretation of positron emission mammography: feature analysis and rates of malignancy. AJR Am J Roentgenol. 196(4):956-70, 2011
Sohns C et al: Value of the BI-RADS classification in MR-Mammography for diagnosis of benign and malignant breast tumors. Eur Radiol. 21(12):2475-83, 2011
Mossa-Basha M et al: Ductal carcinoma in situ of the breast: MR imaging findings with histopathologic correlation. Radiographics. 30:1673-87, 2010
Yamada T et al: Radiologic-pathologic correlation of ductal carcinoma in situ. Radiographics. 30(5):1183-98, 2010
Demartini WB et al: Utility of targeted sonography for breast lesions that were suspicious on MRI. AJR Am J Roentgenol. 192(4):1128-34, 2009
Meissnitzer M et al: Targeted ultrasound of the breast in women with abnormal MRI findings for whom biopsy has been recommended. AJR Am J Roentgenol. 193(4):1025-9, 2009
Sakamoto N et al: Categorization of non-mass-like breast lesions detected by MRI. Breast Cancer. 15(3):241-6, 2008
Yuen S et al: Segmental enhancement on breast MR images: differential diagnosis and diagnostic strategy. Eur Radiol.
Tozaki M et al: High-spatial-resolution MRI of non-masslike breast lesions: interpretation model based on BI-RADS MRI descriptors. AJR Am J Roentgenol. 187(2):330-7, 2006
Morakkabati-Spitz N et al: Diagnostic usefulness of segmental and linear enhancement in dynamic breast MRI. Eur Radiol. 15(9):2010-7, 2005
Liberman L et al: Breast lesions detected on MR imaging: features and positive predictive value. AJR Am J Roentgenol. 179(1):171-8, 2002
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