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Serous Cystadenoma of Pancreas
Tara A. Morgan, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          • Diagnostic Checklist

            TERMINOLOGY

            • Abbreviations

              • Serous cystadenoma (SCA)
            • Synonyms

              • Pancreatic serous cystic neoplasm (SCN), glycogen-rich cystadenoma, microcystic adenoma of pancreas
            • Definitions

              • Benign epithelial neoplasm arising from centroacinar cells of exocrine pancreas, composed of small, proteinaceous cysts separated by fibrovascular septa

            IMAGING

            • General Features

              • Radiographic Findings

                • Ultrasonographic Findings

                  • CT Findings

                    • MR Findings

                      • Imaging Recommendations

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Gross Pathologic & Surgical Features

                              • Microscopic Features

                                CLINICAL ISSUES

                                • Presentation

                                  • Demographics

                                    • Natural History & Prognosis

                                      • Treatment

                                        Selected References

                                        1. Abraham AS et al: Role of cross-sectional imaging (CT/MRI) in characterization and distinguishing benign from malignant/potentially malignant cystic lesions of pancreas. J Clin Imaging Sci. 10:28, 2020
                                        2. Sydney GI et al: EUS-FNA diagnosis of pancreatic serous cystadenoma with the aid of cell blocks and α-inhibin immunochemistry: a case series. Diagn Cytopathol. 48(3):239-43, 2020
                                        3. Giambelluca D et al: The honeycomb pattern of pancreatic serous cystadenoma. Abdom Radiol (NY). 44(3):1191-2, 2019
                                        4. Chu LC et al: The many faces of pancreatic serous cystadenoma: radiologic and pathologic correlation. Diagn Interv Imaging. 98(3):191-202, 2017
                                        5. But DY et al: To fine needle aspiration or not? An endosonographer's approach to pancreatic cystic lesions. Endosc Ultrasound. 3(2):82-90, 2014
                                        6. Khashab MA et al: Should we do EUS/FNA on patients with pancreatic cysts? The incremental diagnostic yield of EUS over CT/MRI for prediction of cystic neoplasms. Pancreas. 42(4):717-21, 2013
                                        7. Dewhurst CE et al: Cystic tumors of the pancreas: imaging and management. Radiol Clin North Am. 50(3):467-86, 2012
                                        8. Kucera JN et al: Cystic lesions of the pancreas: radiologic-endosonographic correlation. Radiographics. 32(7):E283-301, 2012
                                        9. Khashab MA et al: Tumor size and location correlate with behavior of pancreatic serous cystic neoplasms. Am J Gastroenterol. 106(8):1521-6, 2011
                                        10. Choi JY et al: Typical and atypical manifestations of serous cystadenoma of the pancreas: imaging findings with pathologic correlation. AJR Am J Roentgenol. 193(1):136-42, 2009
                                        11. Sand J et al: The differentiation between pancreatic neoplastic cysts and pancreatic pseudocyst. Scand J Surg. 94(2):161-4, 2005
                                        12. Goldsmith JD: Cystic neoplasms of the pancreas. Am J Clin Pathol. 119 Suppl:S3-16, 2003
                                        13. Sheth S et al: Imaging of uncommon tumors of the pancreas. Radiol Clin North Am. 40(6):1273-87, vi, 2002
                                        14. Yeh HC et al: Microcystic features at US: a nonspecific sign for microcystic adenomas of the pancreas. Radiographics. 21(6):1455-61, 2001
                                        Related Anatomy
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                                        Related Differential Diagnoses
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                                        References
                                        Tables

                                        Tables

                                        KEY FACTS

                                        • Terminology

                                          • Imaging

                                            • Top Differential Diagnoses

                                              • Clinical Issues

                                                • Diagnostic Checklist

                                                  TERMINOLOGY

                                                  • Abbreviations

                                                    • Serous cystadenoma (SCA)
                                                  • Synonyms

                                                    • Pancreatic serous cystic neoplasm (SCN), glycogen-rich cystadenoma, microcystic adenoma of pancreas
                                                  • Definitions

                                                    • Benign epithelial neoplasm arising from centroacinar cells of exocrine pancreas, composed of small, proteinaceous cysts separated by fibrovascular septa

                                                  IMAGING

                                                  • General Features

                                                    • Radiographic Findings

                                                      • Ultrasonographic Findings

                                                        • CT Findings

                                                          • MR Findings

                                                            • Imaging Recommendations

                                                              DIFFERENTIAL DIAGNOSIS

                                                                PATHOLOGY

                                                                • General Features

                                                                  • Gross Pathologic & Surgical Features

                                                                    • Microscopic Features

                                                                      CLINICAL ISSUES

                                                                      • Presentation

                                                                        • Demographics

                                                                          • Natural History & Prognosis

                                                                            • Treatment

                                                                              Selected References

                                                                              1. Abraham AS et al: Role of cross-sectional imaging (CT/MRI) in characterization and distinguishing benign from malignant/potentially malignant cystic lesions of pancreas. J Clin Imaging Sci. 10:28, 2020
                                                                              2. Sydney GI et al: EUS-FNA diagnosis of pancreatic serous cystadenoma with the aid of cell blocks and α-inhibin immunochemistry: a case series. Diagn Cytopathol. 48(3):239-43, 2020
                                                                              3. Giambelluca D et al: The honeycomb pattern of pancreatic serous cystadenoma. Abdom Radiol (NY). 44(3):1191-2, 2019
                                                                              4. Chu LC et al: The many faces of pancreatic serous cystadenoma: radiologic and pathologic correlation. Diagn Interv Imaging. 98(3):191-202, 2017
                                                                              5. But DY et al: To fine needle aspiration or not? An endosonographer's approach to pancreatic cystic lesions. Endosc Ultrasound. 3(2):82-90, 2014
                                                                              6. Khashab MA et al: Should we do EUS/FNA on patients with pancreatic cysts? The incremental diagnostic yield of EUS over CT/MRI for prediction of cystic neoplasms. Pancreas. 42(4):717-21, 2013
                                                                              7. Dewhurst CE et al: Cystic tumors of the pancreas: imaging and management. Radiol Clin North Am. 50(3):467-86, 2012
                                                                              8. Kucera JN et al: Cystic lesions of the pancreas: radiologic-endosonographic correlation. Radiographics. 32(7):E283-301, 2012
                                                                              9. Khashab MA et al: Tumor size and location correlate with behavior of pancreatic serous cystic neoplasms. Am J Gastroenterol. 106(8):1521-6, 2011
                                                                              10. Choi JY et al: Typical and atypical manifestations of serous cystadenoma of the pancreas: imaging findings with pathologic correlation. AJR Am J Roentgenol. 193(1):136-42, 2009
                                                                              11. Sand J et al: The differentiation between pancreatic neoplastic cysts and pancreatic pseudocyst. Scand J Surg. 94(2):161-4, 2005
                                                                              12. Goldsmith JD: Cystic neoplasms of the pancreas. Am J Clin Pathol. 119 Suppl:S3-16, 2003
                                                                              13. Sheth S et al: Imaging of uncommon tumors of the pancreas. Radiol Clin North Am. 40(6):1273-87, vi, 2002
                                                                              14. Yeh HC et al: Microcystic features at US: a nonspecific sign for microcystic adenomas of the pancreas. Radiographics. 21(6):1455-61, 2001