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Sertoli and Sertoli-Leydig Cell Tumors
Akram M. Shaaban, MBBCh; Christine O. Menias, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Definitions

              • Ovarian sex cord-stromal tumors
                • Sertoli cell tumors (SCTs)
                • Sertoli-Leydig cell tumors (SLCTs)

            IMAGING

            • General Features

              • CT Findings

                • MR Findings

                  • Ultrasonographic Findings

                    • PET/CT

                      • Imaging Recommendations

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Staging, Grading, & Classification

                              • Gross Pathologic & Surgical Features

                                • Microscopic Features

                                  CLINICAL ISSUES

                                  • Presentation

                                    • Demographics

                                      • Natural History & Prognosis

                                        • Treatment

                                          DIAGNOSTIC CHECKLIST

                                          • Consider

                                            • Image Interpretation Pearls

                                              Selected References

                                              1. Inoue K et al: Pazopanib treatment of a platinum-resistant recurrence of a high-grade Sertoli cell tumor and assessment of the treatment response by FDG-PET/CT: a case report. Gynecol Oncol Rep. 24:54-6, 2018
                                              2. Horta M et al: Sex cord-stromal tumors of the ovary: a comprehensive review and update for radiologists. Diagn Interv Radiol. 21(4):277-86, 2015
                                              3. Cai SQ et al: Ovarian Sertoli-Leydig cell tumors: MRI findings and pathological correlation. J Ovarian Res. 6(1):73, 2013
                                              4. Prassopoulos V et al: Leydig cell tumour of the ovary localised with positron emission tomography/computed tomography. Gynecol Endocrinol. 27(10):837-9, 2011
                                              5. Rio Frio T et al: DICER1 mutations in familial multinodular goiter with and without ovarian Sertoli-Leydig cell tumors. JAMA. 305(1):68-77, 2011
                                              6. Ozülker T et al: Incidental detection of Sertoli-Leydig cell tumor by FDG PET/CT imaging in a patient with androgen insensitivity syndrome. Ann Nucl Med. 24(1):35-9, 2010
                                              7. Shanbhogue AK et al: Clinical syndromes associated with ovarian neoplasms: a comprehensive review. Radiographics. 30(4):903-19, 2010
                                              8. Azuma A et al: A case of Sertoli-Leydig cell tumour of the ovary with a multilocular cystic appearance on CT and MR imaging. Pediatr Radiol. 38(8):898-901, 2008
                                              9. Demidov VN et al: Imaging of gynecological disease (2): clinical and ultrasound characteristics of Sertoli cell tumors, Sertoli-Leydig cell tumors and Leydig cell tumors. Ultrasound Obstet Gynecol. 31(1):85-91, 2008
                                              10. Caringella A et al: A case of Sertoli-Leydig cell tumor in a postmenopausal woman. Int J Gynecol Cancer. 16(1):435-8, 2006
                                              11. Roth LM: Recent advances in the pathology and classification of ovarian sex cord-stromal tumors. Int J Gynecol Pathol. 25(3):199-215, 2006
                                              12. Elbadrawy M et al: Secondary amenorrhoea due to Leydig cell tumour. J Obstet Gynaecol. 25(5):529-30, 2005
                                              13. Jung SE et al: CT and MRI findings of sex cord-stromal tumor of the ovary. AJR Am J Roentgenol. 185(1):207-15, 2005
                                              14. Oliva E et al: Sertoli cell tumors of the ovary: a clinicopathologic and immunohistochemical study of 54 cases. Am J Surg Pathol. 29(2):143-56, 2005
                                              15. Appetecchia M et al: Sertoli-Leydig cell androgens-estrogens secreting tumor of the ovary: ultra-conservative surgery. Eur J Obstet Gynecol Reprod Biol. 116(1):113-6, 2004
                                              16. Tanaka YO et al: Functioning ovarian tumors: direct and indirect findings at MR imaging. Radiographics. 24 Suppl 1:S147-66, 2004
                                              17. Jung SE et al: CT and MR imaging of ovarian tumors with emphasis on differential diagnosis. Radiographics. 22(6):1305-25, 2002
                                              18. Lantzsch T et al: Sertoli-Leydig cell tumor. Arch Gynecol Obstet. 264(4):206-8, 2001
                                              Related Anatomy
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                                              Related Differential Diagnoses
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                                              References
                                              Tables

                                              Tables

                                              KEY FACTS

                                              • Terminology

                                                • Imaging

                                                  • Top Differential Diagnoses

                                                    • Pathology

                                                      • Clinical Issues

                                                        TERMINOLOGY

                                                        • Definitions

                                                          • Ovarian sex cord-stromal tumors
                                                            • Sertoli cell tumors (SCTs)
                                                            • Sertoli-Leydig cell tumors (SLCTs)

                                                        IMAGING

                                                        • General Features

                                                          • CT Findings

                                                            • MR Findings

                                                              • Ultrasonographic Findings

                                                                • PET/CT

                                                                  • Imaging Recommendations

                                                                    DIFFERENTIAL DIAGNOSIS

                                                                      PATHOLOGY

                                                                      • General Features

                                                                        • Staging, Grading, & Classification

                                                                          • Gross Pathologic & Surgical Features

                                                                            • Microscopic Features

                                                                              CLINICAL ISSUES

                                                                              • Presentation

                                                                                • Demographics

                                                                                  • Natural History & Prognosis

                                                                                    • Treatment

                                                                                      DIAGNOSTIC CHECKLIST

                                                                                      • Consider

                                                                                        • Image Interpretation Pearls

                                                                                          Selected References

                                                                                          1. Inoue K et al: Pazopanib treatment of a platinum-resistant recurrence of a high-grade Sertoli cell tumor and assessment of the treatment response by FDG-PET/CT: a case report. Gynecol Oncol Rep. 24:54-6, 2018
                                                                                          2. Horta M et al: Sex cord-stromal tumors of the ovary: a comprehensive review and update for radiologists. Diagn Interv Radiol. 21(4):277-86, 2015
                                                                                          3. Cai SQ et al: Ovarian Sertoli-Leydig cell tumors: MRI findings and pathological correlation. J Ovarian Res. 6(1):73, 2013
                                                                                          4. Prassopoulos V et al: Leydig cell tumour of the ovary localised with positron emission tomography/computed tomography. Gynecol Endocrinol. 27(10):837-9, 2011
                                                                                          5. Rio Frio T et al: DICER1 mutations in familial multinodular goiter with and without ovarian Sertoli-Leydig cell tumors. JAMA. 305(1):68-77, 2011
                                                                                          6. Ozülker T et al: Incidental detection of Sertoli-Leydig cell tumor by FDG PET/CT imaging in a patient with androgen insensitivity syndrome. Ann Nucl Med. 24(1):35-9, 2010
                                                                                          7. Shanbhogue AK et al: Clinical syndromes associated with ovarian neoplasms: a comprehensive review. Radiographics. 30(4):903-19, 2010
                                                                                          8. Azuma A et al: A case of Sertoli-Leydig cell tumour of the ovary with a multilocular cystic appearance on CT and MR imaging. Pediatr Radiol. 38(8):898-901, 2008
                                                                                          9. Demidov VN et al: Imaging of gynecological disease (2): clinical and ultrasound characteristics of Sertoli cell tumors, Sertoli-Leydig cell tumors and Leydig cell tumors. Ultrasound Obstet Gynecol. 31(1):85-91, 2008
                                                                                          10. Caringella A et al: A case of Sertoli-Leydig cell tumor in a postmenopausal woman. Int J Gynecol Cancer. 16(1):435-8, 2006
                                                                                          11. Roth LM: Recent advances in the pathology and classification of ovarian sex cord-stromal tumors. Int J Gynecol Pathol. 25(3):199-215, 2006
                                                                                          12. Elbadrawy M et al: Secondary amenorrhoea due to Leydig cell tumour. J Obstet Gynaecol. 25(5):529-30, 2005
                                                                                          13. Jung SE et al: CT and MRI findings of sex cord-stromal tumor of the ovary. AJR Am J Roentgenol. 185(1):207-15, 2005
                                                                                          14. Oliva E et al: Sertoli cell tumors of the ovary: a clinicopathologic and immunohistochemical study of 54 cases. Am J Surg Pathol. 29(2):143-56, 2005
                                                                                          15. Appetecchia M et al: Sertoli-Leydig cell androgens-estrogens secreting tumor of the ovary: ultra-conservative surgery. Eur J Obstet Gynecol Reprod Biol. 116(1):113-6, 2004
                                                                                          16. Tanaka YO et al: Functioning ovarian tumors: direct and indirect findings at MR imaging. Radiographics. 24 Suppl 1:S147-66, 2004
                                                                                          17. Jung SE et al: CT and MR imaging of ovarian tumors with emphasis on differential diagnosis. Radiographics. 22(6):1305-25, 2002
                                                                                          18. Lantzsch T et al: Sertoli-Leydig cell tumor. Arch Gynecol Obstet. 264(4):206-8, 2001