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Sickle Cell, Acute Chest Syndrome
Helen T. Winer-Muram, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Abbreviations

                • Sickle cell disease (Hb SS)
                • Acute chest syndrome (ACS)
              • Definitions

                • Sickle cell disease: Abnormal hemoglobin that deforms when deoxygenated
                • Acute chest syndrome: Noninfectious vasoocclusive crisis in patients with Hb SS associated with chest radiographic abnormalities
                  • Initiated by lung infection or infarction
                • Sickle cell chronic lung disease: Result of recurrent acute chest syndrome

              IMAGING

              • General Features

                • Radiographic Findings

                  • CT Findings

                    • Nuclear Medicine Findings

                      • Imaging Recommendations

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Microscopic Features

                              CLINICAL ISSUES

                              • Presentation

                                • Demographics

                                  • Natural History & Prognosis

                                    • Treatment

                                      DIAGNOSTIC CHECKLIST

                                      • Consider

                                        Selected References

                                        1. Gladwin MT et al: Pulmonary complications of sickle cell disease. N Engl J Med. 359(21):2254-65, 2008
                                        2. Delclaux C et al: Factors associated with dyspnea in adult patients with sickle cell disease. Chest. 128(5):3336-44, 2005
                                        3. Maitre B et al: Acute chest syndrome in adults with sickle cell disease. Chest. 117(5):1386-92, 2000
                                        Related Anatomy
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                                        Related Differential Diagnoses
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                                        References
                                        Tables

                                        Tables

                                        KEY FACTS

                                        • Terminology

                                          • Imaging

                                            • Top Differential Diagnoses

                                              • Pathology

                                                • Clinical Issues

                                                  • Diagnostic Checklist

                                                    TERMINOLOGY

                                                    • Abbreviations

                                                      • Sickle cell disease (Hb SS)
                                                      • Acute chest syndrome (ACS)
                                                    • Definitions

                                                      • Sickle cell disease: Abnormal hemoglobin that deforms when deoxygenated
                                                      • Acute chest syndrome: Noninfectious vasoocclusive crisis in patients with Hb SS associated with chest radiographic abnormalities
                                                        • Initiated by lung infection or infarction
                                                      • Sickle cell chronic lung disease: Result of recurrent acute chest syndrome

                                                    IMAGING

                                                    • General Features

                                                      • Radiographic Findings

                                                        • CT Findings

                                                          • Nuclear Medicine Findings

                                                            • Imaging Recommendations

                                                              DIFFERENTIAL DIAGNOSIS

                                                                PATHOLOGY

                                                                • General Features

                                                                  • Microscopic Features

                                                                    CLINICAL ISSUES

                                                                    • Presentation

                                                                      • Demographics

                                                                        • Natural History & Prognosis

                                                                          • Treatment

                                                                            DIAGNOSTIC CHECKLIST

                                                                            • Consider

                                                                              Selected References

                                                                              1. Gladwin MT et al: Pulmonary complications of sickle cell disease. N Engl J Med. 359(21):2254-65, 2008
                                                                              2. Delclaux C et al: Factors associated with dyspnea in adult patients with sickle cell disease. Chest. 128(5):3336-44, 2005
                                                                              3. Maitre B et al: Acute chest syndrome in adults with sickle cell disease. Chest. 117(5):1386-92, 2000