link
Bookmarks
Gastrointestinal
Diagnosis
Abdominal Manifestations of Systemic Conditions
Metabolic or Inherited
Sickle Cell Anemia
Sickle Cell Anemia
Siva P. Raman, MD
To access 4,300 diagnoses written by the world's leading experts in radiology.Try it free - 15 days
0
6
2
1

KEY FACTS

  • Terminology

    • Imaging

      TERMINOLOGY

      • Abbreviations

        • Sickle cell anemia (SCA)

      • Definitions

        • Inherited hemolytic anemia arising due to abnormal hemoglobin (hemoglobin S), resulting in deformation of red blood cells and leading to microvascular occlusions and infarcts

      IMAGING

      • General Features

        • CT Findings

          • MR Findings

            • Ultrasonographic Findings

              • Radiographic Findings

                • Imaging Recommendations

                  DIFFERENTIAL DIAGNOSIS

                    PATHOLOGY

                    • General Features

                      • Staging, Grading, & Classification

                        • Gross Pathologic & Surgical Features

                          • Microscopic Features

                            CLINICAL ISSUES

                            • Presentation

                              • Demographics

                                • Natural History & Prognosis

                                  • Treatment

                                    DIAGNOSTIC CHECKLIST

                                    • Consider

                                      Selected References

                                      1. Kinger NP et al: Abdominal manifestations of sickle cell disease. Curr Probl Diagn Radiol. 50(2):241-51, 2020
                                      2. Riminucci M et al: Re: Renal medullary carcinoma and its association with sickle cell trait: a case report and literature review. Curr Oncol. 27(3):e348, 2020
                                      3. Orphanidou-Vlachou E et al: Extramedullary hemopoiesis. Semin Ultrasound CT MR. 35(3):255-62, 2014
                                      4. Al-Salem AH: Massive splenic infarction in children with sickle cell anemia and the role of splenectomy. Pediatr Surg Int. 29(3):281-5, 2013
                                      5. Raman SP et al: Beyond renal cell carcinoma: rare and unusual renal masses. Abdom Imaging. 37(5):873-84, 2012
                                      6. Al-Salem AH: Splenic complications of sickle cell anemia and the role of splenectomy. ISRN Hematol. 2011:864257, 2011
                                      7. Brewer CJ et al: Spleen R2 and R2* in iron-overloaded patients with sickle cell disease and thalassemia major. J Magn Reson Imaging. 29(2):357-64, 2009
                                      8. Khatib R et al: The spleen in the sickling disorders: an update. Pediatr Radiol. 39(1):17-22, 2009
                                      9. Balci A et al: Prevalence of abdominal ultrasonographic abnormalities in patients with sickle cell disease. Diagn Interv Radiol. 14(3):133-7, 2008
                                      10. Mestre-Fusco A et al: Sickle cell anemia and functioning splenic tissue: correlation of scintigraphic findings and CT. Clin Nucl Med. 33(2):137-9, 2008
                                      11. Papadaki MG et al: Abdominal ultrasonographic findings in patients with sickle-cell anaemia and thalassaemia intermedia. Pediatr Radiol. 33(8):515-21, 2003
                                      12. Lonergan GJ et al: Sickle cell anemia. Radiographics. 21(4):971-94, 2001
                                      13. Sheth S et al: CT imaging of splenic sequestration in sickle cell disease. Pediatr Radiol. 30(12):830-3, 2000
                                      14. Siegelman ES et al: Abdominal iron distribution in sickle cell disease: MR findings in transfusion and nontransfusion dependent patients. J Comput Assist Tomogr. 18(1):63-7, 1994
                                      15. D'Alonzo WA Jr et al: Biliary scintigraphy in children with sickle cell anemia and acute abdominal pain. Pediatr Radiol. 15(6):395-8, 1985
                                      Related Anatomy
                                      Loading...
                                      Related Differential Diagnoses
                                      Loading...
                                      References
                                      Tables

                                      Tables

                                      KEY FACTS

                                      • Terminology

                                        • Imaging

                                          TERMINOLOGY

                                          • Abbreviations

                                            • Sickle cell anemia (SCA)

                                          • Definitions

                                            • Inherited hemolytic anemia arising due to abnormal hemoglobin (hemoglobin S), resulting in deformation of red blood cells and leading to microvascular occlusions and infarcts

                                          IMAGING

                                          • General Features

                                            • CT Findings

                                              • MR Findings

                                                • Ultrasonographic Findings

                                                  • Radiographic Findings

                                                    • Imaging Recommendations

                                                      DIFFERENTIAL DIAGNOSIS

                                                        PATHOLOGY

                                                        • General Features

                                                          • Staging, Grading, & Classification

                                                            • Gross Pathologic & Surgical Features

                                                              • Microscopic Features

                                                                CLINICAL ISSUES

                                                                • Presentation

                                                                  • Demographics

                                                                    • Natural History & Prognosis

                                                                      • Treatment

                                                                        DIAGNOSTIC CHECKLIST

                                                                        • Consider

                                                                          Selected References

                                                                          1. Kinger NP et al: Abdominal manifestations of sickle cell disease. Curr Probl Diagn Radiol. 50(2):241-51, 2020
                                                                          2. Riminucci M et al: Re: Renal medullary carcinoma and its association with sickle cell trait: a case report and literature review. Curr Oncol. 27(3):e348, 2020
                                                                          3. Orphanidou-Vlachou E et al: Extramedullary hemopoiesis. Semin Ultrasound CT MR. 35(3):255-62, 2014
                                                                          4. Al-Salem AH: Massive splenic infarction in children with sickle cell anemia and the role of splenectomy. Pediatr Surg Int. 29(3):281-5, 2013
                                                                          5. Raman SP et al: Beyond renal cell carcinoma: rare and unusual renal masses. Abdom Imaging. 37(5):873-84, 2012
                                                                          6. Al-Salem AH: Splenic complications of sickle cell anemia and the role of splenectomy. ISRN Hematol. 2011:864257, 2011
                                                                          7. Brewer CJ et al: Spleen R2 and R2* in iron-overloaded patients with sickle cell disease and thalassemia major. J Magn Reson Imaging. 29(2):357-64, 2009
                                                                          8. Khatib R et al: The spleen in the sickling disorders: an update. Pediatr Radiol. 39(1):17-22, 2009
                                                                          9. Balci A et al: Prevalence of abdominal ultrasonographic abnormalities in patients with sickle cell disease. Diagn Interv Radiol. 14(3):133-7, 2008
                                                                          10. Mestre-Fusco A et al: Sickle cell anemia and functioning splenic tissue: correlation of scintigraphic findings and CT. Clin Nucl Med. 33(2):137-9, 2008
                                                                          11. Papadaki MG et al: Abdominal ultrasonographic findings in patients with sickle-cell anaemia and thalassaemia intermedia. Pediatr Radiol. 33(8):515-21, 2003
                                                                          12. Lonergan GJ et al: Sickle cell anemia. Radiographics. 21(4):971-94, 2001
                                                                          13. Sheth S et al: CT imaging of splenic sequestration in sickle cell disease. Pediatr Radiol. 30(12):830-3, 2000
                                                                          14. Siegelman ES et al: Abdominal iron distribution in sickle cell disease: MR findings in transfusion and nontransfusion dependent patients. J Comput Assist Tomogr. 18(1):63-7, 1994
                                                                          15. D'Alonzo WA Jr et al: Biliary scintigraphy in children with sickle cell anemia and acute abdominal pain. Pediatr Radiol. 15(6):395-8, 1985