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Sickle Cell Anemia
Siva P. Raman, MD
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KEY FACTS

  • Terminology

    • Imaging

      TERMINOLOGY

      • Abbreviations

        • Sickle cell anemia (SCA)
      • Definitions

        • Inherited hemolytic anemia arising due to abnormal hemoglobin (hemoglobin S), resulting in deformation of red blood cells and leading to microvascular occlusions and infarcts

      IMAGING

      • General Features

        • CT Findings

          • MR Findings

            • Ultrasonographic Findings

              • Radiographic Findings

                • Imaging Recommendations

                  DIFFERENTIAL DIAGNOSIS

                    PATHOLOGY

                    • General Features

                      • Staging, Grading, & Classification

                        • Gross Pathologic & Surgical Features

                          • Microscopic Features

                            CLINICAL ISSUES

                            • Presentation

                              • Demographics

                                • Natural History & Prognosis

                                  • Treatment

                                    DIAGNOSTIC CHECKLIST

                                    • Consider

                                      Selected References

                                      1. Orphanidou-Vlachou E et al: Extramedullary hemopoiesis. Semin Ultrasound CT MR. 35(3):255-62, 2014
                                      2. Al-Salem AH: Massive splenic infarction in children with sickle cell anemia and the role of splenectomy. Pediatr Surg Int. 29(3):281-5, 2013
                                      3. Raman SP et al: Beyond renal cell carcinoma: rare and unusual renal masses. Abdom Imaging. 37(5):873-84, 2012
                                      4. Al-Salem AH: Splenic complications of sickle cell anemia and the role of splenectomy. ISRN Hematol. 2011:864257, 2011
                                      5. Brewer CJ et al: Spleen R2 and R2* in iron-overloaded patients with sickle cell disease and thalassemia major. J Magn Reson Imaging. 29(2):357-64, 2009
                                      6. Khatib R et al: The spleen in the sickling disorders: an update. Pediatr Radiol. 39(1):17-22, 2009
                                      7. Balci A et al: Prevalence of abdominal ultrasonographic abnormalities in patients with sickle cell disease. Diagn Interv Radiol. 14(3):133-7, 2008
                                      8. Mestre-Fusco A et al: Sickle cell anemia and functioning splenic tissue: correlation of scintigraphic findings and CT. Clin Nucl Med. 33(2):137-9, 2008
                                      9. Papadaki MG et al: Abdominal ultrasonographic findings in patients with sickle-cell anaemia and thalassaemia intermedia. Pediatr Radiol. 33(8):515-21, 2003
                                      10. Lonergan GJ et al: Sickle cell anemia. Radiographics. 21(4):971-94, 2001
                                      11. Sheth S et al: CT imaging of splenic sequestration in sickle cell disease. Pediatr Radiol. 30(12):830-3, 2000
                                      12. Siegelman ES et al: Abdominal iron distribution in sickle cell disease: MR findings in transfusion and nontransfusion dependent patients. J Comput Assist Tomogr. 18(1):63-7, 1994
                                      13. D'Alonzo WA Jr et al: Biliary scintigraphy in children with sickle cell anemia and acute abdominal pain. Pediatr Radiol. 15(6):395-8, 1985
                                      Related Anatomy
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                                      Related Differential Diagnoses
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                                      References
                                      Tables

                                      Tables

                                      KEY FACTS

                                      • Terminology

                                        • Imaging

                                          TERMINOLOGY

                                          • Abbreviations

                                            • Sickle cell anemia (SCA)
                                          • Definitions

                                            • Inherited hemolytic anemia arising due to abnormal hemoglobin (hemoglobin S), resulting in deformation of red blood cells and leading to microvascular occlusions and infarcts

                                          IMAGING

                                          • General Features

                                            • CT Findings

                                              • MR Findings

                                                • Ultrasonographic Findings

                                                  • Radiographic Findings

                                                    • Imaging Recommendations

                                                      DIFFERENTIAL DIAGNOSIS

                                                        PATHOLOGY

                                                        • General Features

                                                          • Staging, Grading, & Classification

                                                            • Gross Pathologic & Surgical Features

                                                              • Microscopic Features

                                                                CLINICAL ISSUES

                                                                • Presentation

                                                                  • Demographics

                                                                    • Natural History & Prognosis

                                                                      • Treatment

                                                                        DIAGNOSTIC CHECKLIST

                                                                        • Consider

                                                                          Selected References

                                                                          1. Orphanidou-Vlachou E et al: Extramedullary hemopoiesis. Semin Ultrasound CT MR. 35(3):255-62, 2014
                                                                          2. Al-Salem AH: Massive splenic infarction in children with sickle cell anemia and the role of splenectomy. Pediatr Surg Int. 29(3):281-5, 2013
                                                                          3. Raman SP et al: Beyond renal cell carcinoma: rare and unusual renal masses. Abdom Imaging. 37(5):873-84, 2012
                                                                          4. Al-Salem AH: Splenic complications of sickle cell anemia and the role of splenectomy. ISRN Hematol. 2011:864257, 2011
                                                                          5. Brewer CJ et al: Spleen R2 and R2* in iron-overloaded patients with sickle cell disease and thalassemia major. J Magn Reson Imaging. 29(2):357-64, 2009
                                                                          6. Khatib R et al: The spleen in the sickling disorders: an update. Pediatr Radiol. 39(1):17-22, 2009
                                                                          7. Balci A et al: Prevalence of abdominal ultrasonographic abnormalities in patients with sickle cell disease. Diagn Interv Radiol. 14(3):133-7, 2008
                                                                          8. Mestre-Fusco A et al: Sickle cell anemia and functioning splenic tissue: correlation of scintigraphic findings and CT. Clin Nucl Med. 33(2):137-9, 2008
                                                                          9. Papadaki MG et al: Abdominal ultrasonographic findings in patients with sickle-cell anaemia and thalassaemia intermedia. Pediatr Radiol. 33(8):515-21, 2003
                                                                          10. Lonergan GJ et al: Sickle cell anemia. Radiographics. 21(4):971-94, 2001
                                                                          11. Sheth S et al: CT imaging of splenic sequestration in sickle cell disease. Pediatr Radiol. 30(12):830-3, 2000
                                                                          12. Siegelman ES et al: Abdominal iron distribution in sickle cell disease: MR findings in transfusion and nontransfusion dependent patients. J Comput Assist Tomogr. 18(1):63-7, 1994
                                                                          13. D'Alonzo WA Jr et al: Biliary scintigraphy in children with sickle cell anemia and acute abdominal pain. Pediatr Radiol. 15(6):395-8, 1985