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KEY FACTS
Terminology
Imaging
Diagnostic Checklist
TERMINOLOGY
Abbreviations
- Sickle cell (SC) disease
Definitions
- Homozygous HbSS (autosomal recessive) inherited hemoglobinopathy
- Musculoskeletal imaging findings reflect one or both of the following processes
- Chronic hemolytic anemia
- Microvascular occlusion created by sickled red blood cells when exposed to low oxygen tension
- Musculoskeletal imaging findings reflect one or both of the following processes
- Heterozygous: HbSA (sickle cell trait), HbSC (↓ severity)
- Homozygous HbSS (autosomal recessive) inherited hemoglobinopathy
IMAGING
General Features
Radiographic Findings
MR Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Image Interpretation Pearls
Selected References
- Key NS et al: Negative health implications of sickle cell trait in high income countries: from the football field to the laboratory. Br J Haematol. ePub, 2015
- Walters MC: Update of hematopoietic cell transplantation for sickle cell disease. Curr Opin Hematol. 22(3):227-33, 2015
- Wood JC: Estimating tissue iron burden: current status and future prospects. Br J Haematol. ePub, 2015
- Ihde LL et al: Sclerosing bone dysplasias: review and differentiation from other causes of osteosclerosis. Radiographics. 31(7):1865-82, 2011
- Jain R et al: Acute bone crises in sickle cell disease: the T1 fat-saturated sequence in differentiation of acute bone infarcts from acute osteomyelitis. Clin Radiol. 63(1):59-70, 2008
- Ejindu VC et al: Musculoskeletal manifestations of sickle cell disease. Radiographics. 27(4):1005-21, 2007
- Sathappan SS et al: Multidisciplinary management of orthopedic patients with sickle cell disease. Orthopedics. 29(12):1094-101; quiz 1102-3, 2006
- Umans H et al: The diagnostic role of gadolinium enhanced MRI in distinguishing between acute medullary bone infarct and osteomyelitis. Magn Reson Imaging. 18(3):255-62, 2000
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Related Differential Diagnoses
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Diagnostic Checklist
TERMINOLOGY
Abbreviations
- Sickle cell (SC) disease
Definitions
- Homozygous HbSS (autosomal recessive) inherited hemoglobinopathy
- Musculoskeletal imaging findings reflect one or both of the following processes
- Chronic hemolytic anemia
- Microvascular occlusion created by sickled red blood cells when exposed to low oxygen tension
- Musculoskeletal imaging findings reflect one or both of the following processes
- Heterozygous: HbSA (sickle cell trait), HbSC (↓ severity)
- Homozygous HbSS (autosomal recessive) inherited hemoglobinopathy
IMAGING
General Features
Radiographic Findings
MR Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Image Interpretation Pearls
Selected References
- Key NS et al: Negative health implications of sickle cell trait in high income countries: from the football field to the laboratory. Br J Haematol. ePub, 2015
- Walters MC: Update of hematopoietic cell transplantation for sickle cell disease. Curr Opin Hematol. 22(3):227-33, 2015
- Wood JC: Estimating tissue iron burden: current status and future prospects. Br J Haematol. ePub, 2015
- Ihde LL et al: Sclerosing bone dysplasias: review and differentiation from other causes of osteosclerosis. Radiographics. 31(7):1865-82, 2011
- Jain R et al: Acute bone crises in sickle cell disease: the T1 fat-saturated sequence in differentiation of acute bone infarcts from acute osteomyelitis. Clin Radiol. 63(1):59-70, 2008
- Ejindu VC et al: Musculoskeletal manifestations of sickle cell disease. Radiographics. 27(4):1005-21, 2007
- Sathappan SS et al: Multidisciplinary management of orthopedic patients with sickle cell disease. Orthopedics. 29(12):1094-101; quiz 1102-3, 2006
- Umans H et al: The diagnostic role of gadolinium enhanced MRI in distinguishing between acute medullary bone infarct and osteomyelitis. Magn Reson Imaging. 18(3):255-62, 2000
