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Silo-Filler's Disease
Tyler H. Ternes, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          • Diagnostic Checklist

            TERMINOLOGY

            • Abbreviations

              • Nitrogen dioxide (NO₂)
            • Definitions

              • Occupational lung disease resulting from exposure to NO₂
              • Inhalation of toxic gases from freshly stored silage
              • Similar gases: Welding, glassblowing, Zamboni ice resurfacing, manufacturing (lacquers, dyes, rocket propellants, fertilizers), metal cleaning, rayon and food bleaching, nitrocellulose incineration

            IMAGING

            • General Features

              • Radiographic Findings

                • CT Findings

                  • Nuclear Medicine Findings

                    • Imaging Recommendations

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Microscopic Features

                            CLINICAL ISSUES

                            • Presentation

                              • Demographics

                                • Natural History & Prognosis

                                  • Treatment

                                    DIAGNOSTIC CHECKLIST

                                    • Consider

                                      Selected References

                                      1. Amaducci A et al: Nitrogen Dioxide Toxicity 2021
                                      2. Amaza IP et al: Silo-filler's disease: one health system's experience and an update of the literature. J Agromedicine. 25(1):8-13, 2020
                                      3. Leavey JF et al: Silo-filler's disease, the acute respiratory distress syndrome, and oxides of nitrogen. Ann Intern Med. 141(5):410-1, 2004
                                      4. Jackson L: Grain silo cleanup operation leads to two occupational deaths. Appl Occup Environ Hyg. 17(7):464-6, 2002
                                      5. Stepanek J et al: Case in point. Silo fillers lung. Hosp Pract (Minneap). 33(1):70, 1998
                                      6. Gurney JW et al: Agricultural disorders of the lung. Radiographics. 11(4):625-34, 1991
                                      Related Anatomy
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                                      Related Differential Diagnoses
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                                      References
                                      Tables

                                      Tables

                                      KEY FACTS

                                      • Terminology

                                        • Imaging

                                          • Top Differential Diagnoses

                                            • Clinical Issues

                                              • Diagnostic Checklist

                                                TERMINOLOGY

                                                • Abbreviations

                                                  • Nitrogen dioxide (NO₂)
                                                • Definitions

                                                  • Occupational lung disease resulting from exposure to NO₂
                                                  • Inhalation of toxic gases from freshly stored silage
                                                  • Similar gases: Welding, glassblowing, Zamboni ice resurfacing, manufacturing (lacquers, dyes, rocket propellants, fertilizers), metal cleaning, rayon and food bleaching, nitrocellulose incineration

                                                IMAGING

                                                • General Features

                                                  • Radiographic Findings

                                                    • CT Findings

                                                      • Nuclear Medicine Findings

                                                        • Imaging Recommendations

                                                          DIFFERENTIAL DIAGNOSIS

                                                            PATHOLOGY

                                                            • General Features

                                                              • Microscopic Features

                                                                CLINICAL ISSUES

                                                                • Presentation

                                                                  • Demographics

                                                                    • Natural History & Prognosis

                                                                      • Treatment

                                                                        DIAGNOSTIC CHECKLIST

                                                                        • Consider

                                                                          Selected References

                                                                          1. Amaducci A et al: Nitrogen Dioxide Toxicity 2021
                                                                          2. Amaza IP et al: Silo-filler's disease: one health system's experience and an update of the literature. J Agromedicine. 25(1):8-13, 2020
                                                                          3. Leavey JF et al: Silo-filler's disease, the acute respiratory distress syndrome, and oxides of nitrogen. Ann Intern Med. 141(5):410-1, 2004
                                                                          4. Jackson L: Grain silo cleanup operation leads to two occupational deaths. Appl Occup Environ Hyg. 17(7):464-6, 2002
                                                                          5. Stepanek J et al: Case in point. Silo fillers lung. Hosp Pract (Minneap). 33(1):70, 1998
                                                                          6. Gurney JW et al: Agricultural disorders of the lung. Radiographics. 11(4):625-34, 1991