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Simple Bone Cyst
Behrang Amini, MD, PhD; B. J. Manaster, MD, PhD, FACR
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          • Diagnostic Checklist

            TERMINOLOGY

            • Abbreviations

              • Simple bone cyst (SBC)
            • Synonyms

              • Solitary bone cyst, unicameral bone cyst (not recommended), juvenile bone cyst, essential bone cyst
            • Definitions

              • Benign, intramedullary, usually unilocular, fluid-filled bone lesion lined by fibrous membrane

            IMAGING

            • General Features

              • Radiographic Findings

                • CT Findings

                  • MR Findings

                    • Nuclear Medicine Findings

                      • Fluoroscopic Findings

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Gross Pathologic & Surgical Features

                              • Microscopic Features

                                CLINICAL ISSUES

                                • Presentation

                                  • Demographics

                                    • Natural History & Prognosis

                                      • Treatment

                                        DIAGNOSTIC CHECKLIST

                                        • Image Interpretation Pearls

                                          Selected References

                                          1. Deventer N et al: Current strategies for the treatment of solitary and aneurysmal bone cysts: a review of the literature. J Bone Oncol. 30:100384, 2021
                                          2. Murai NO et al: Bone and soft tissue tumors about the foot and ankle. Radiol Clin North Am. 56(6):917-34, 2018
                                          3. Noordin S et al: Unicameral bone cysts: current concepts. Ann Med Surg (Lond). 34:43-9, 2018
                                          4. Pretell-Mazzini J et al: Unicameral bone cysts: general characteristics and management controversies. J Am Acad Orthop Surg. 22(5):295-303, 2014
                                          5. Tariq MU et al: Cementum-like matrix in solitary bone cysts: a unique and characteristic but yet underrecognized feature of promising diagnostic utility. Ann Diagn Pathol. 18(1):1-4, 2014
                                          6. Hou HY et al: Treatment of unicameral bone cyst: a comparative study of selected techniques. J Bone Joint Surg Am. 92(4):855-62, 2010
                                          7. Pedzisz P et al: Treatment of solitary bone cysts with allogenic bone graft and platelet-rich plasma. A preliminary report. Acta Orthop Belg. 76(3):374-9, 2010
                                          8. Sakamoto A et al: Clinical outcome following surgical intervention for a solitary bone cyst: emphasis on treatment by curettage and steroid injection. J Orthop Sci. 15(4):553-9, 2010
                                          9. Teoh KH et al: Predictive factors for recurrence of simple bone cyst of the proximal humerus. J Orthop Surg (Hong Kong). 18(2):215-9, 2010
                                          10. Jordanov MI: The "rising bubble" sign: a new aid in the diagnosis of unicameral bone cysts. Skeletal Radiol. 38(6):597-600, 2009
                                          11. Khurana A et al: Benign bone cyst mimicking skeletal metastasis on (18)F-FDG-PET. Hell J Nucl Med. 12(2):179-80, 2009
                                          12. Mik G et al: Results of a minimally invasive technique for treatment of unicameral bone cysts. Clin Orthop Relat Res. 467(11):2949-54, 2009
                                          13. Polat O et al: Our clinical experience on calcaneal bone cysts: 36 cysts in 33 patients. Arch Orthop Trauma Surg. 129(11):1489-94, 2009
                                          14. Ruggieri P et al: Tumours and tumour-like lesions of the hip in the paediatric age: a review of the Rizzoli experience. Hip Int. 19 Suppl 6:S35-45, 2009
                                          15. Tey IK et al: Active unicameral bone cysts in the upper limb are at greater risk of fracture. J Orthop Surg (Hong Kong). 17(2):157-60, 2009
                                          16. Thawrani D et al: Successful treatment of unicameral bone cyst by single percutaneous injection of alpha-BSM. J Pediatr Orthop. 29(5):511-7, 2009
                                          17. Wootton-Gorges SL: MR imaging of primary bone tumors and tumor-like conditions in children. Magn Reson Imaging Clin N Am. 17(3):469-87, vi, 2009
                                          18. Sung AD et al: Unicameral bone cyst: a retrospective study of three surgical treatments. Clin Orthop Relat Res. 466(10):2519-26, 2008
                                          19. Snyder BD et al: Predicting fracture through benign skeletal lesions with quantitative computed tomography. J Bone Joint Surg Am. 88(1):55-70, 2006
                                          20. Shankman S et al: MR imaging of tumors and tumor-like lesions of the upper extremity. Magn Reson Imaging Clin N Am. 12(2):349-59, 2004
                                          21. Zampa V et al: MR evaluation of bone cysts treated with intracavital steroid injection. Eur Radiol. 13(6):1348-56, 2003
                                          22. Abdel-Wanis ME et al: Simple bone cyst is not a single entity: point of view based on a literature review. Med Hypotheses. 58(1):87-91, 2002
                                          23. Kalil RK et al: Simple bone cyst. In Fletcher CDM et al: World Health Organization Classification of Tumours: Tumours of Soft Tissue and Bone. IARC Press, 2002
                                          Related Anatomy
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                                          Related Differential Diagnoses
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                                          References
                                          Tables

                                          Tables

                                          KEY FACTS

                                          • Terminology

                                            • Imaging

                                              • Top Differential Diagnoses

                                                • Clinical Issues

                                                  • Diagnostic Checklist

                                                    TERMINOLOGY

                                                    • Abbreviations

                                                      • Simple bone cyst (SBC)
                                                    • Synonyms

                                                      • Solitary bone cyst, unicameral bone cyst (not recommended), juvenile bone cyst, essential bone cyst
                                                    • Definitions

                                                      • Benign, intramedullary, usually unilocular, fluid-filled bone lesion lined by fibrous membrane

                                                    IMAGING

                                                    • General Features

                                                      • Radiographic Findings

                                                        • CT Findings

                                                          • MR Findings

                                                            • Nuclear Medicine Findings

                                                              • Fluoroscopic Findings

                                                                DIFFERENTIAL DIAGNOSIS

                                                                  PATHOLOGY

                                                                  • General Features

                                                                    • Gross Pathologic & Surgical Features

                                                                      • Microscopic Features

                                                                        CLINICAL ISSUES

                                                                        • Presentation

                                                                          • Demographics

                                                                            • Natural History & Prognosis

                                                                              • Treatment

                                                                                DIAGNOSTIC CHECKLIST

                                                                                • Image Interpretation Pearls

                                                                                  Selected References

                                                                                  1. Deventer N et al: Current strategies for the treatment of solitary and aneurysmal bone cysts: a review of the literature. J Bone Oncol. 30:100384, 2021
                                                                                  2. Murai NO et al: Bone and soft tissue tumors about the foot and ankle. Radiol Clin North Am. 56(6):917-34, 2018
                                                                                  3. Noordin S et al: Unicameral bone cysts: current concepts. Ann Med Surg (Lond). 34:43-9, 2018
                                                                                  4. Pretell-Mazzini J et al: Unicameral bone cysts: general characteristics and management controversies. J Am Acad Orthop Surg. 22(5):295-303, 2014
                                                                                  5. Tariq MU et al: Cementum-like matrix in solitary bone cysts: a unique and characteristic but yet underrecognized feature of promising diagnostic utility. Ann Diagn Pathol. 18(1):1-4, 2014
                                                                                  6. Hou HY et al: Treatment of unicameral bone cyst: a comparative study of selected techniques. J Bone Joint Surg Am. 92(4):855-62, 2010
                                                                                  7. Pedzisz P et al: Treatment of solitary bone cysts with allogenic bone graft and platelet-rich plasma. A preliminary report. Acta Orthop Belg. 76(3):374-9, 2010
                                                                                  8. Sakamoto A et al: Clinical outcome following surgical intervention for a solitary bone cyst: emphasis on treatment by curettage and steroid injection. J Orthop Sci. 15(4):553-9, 2010
                                                                                  9. Teoh KH et al: Predictive factors for recurrence of simple bone cyst of the proximal humerus. J Orthop Surg (Hong Kong). 18(2):215-9, 2010
                                                                                  10. Jordanov MI: The "rising bubble" sign: a new aid in the diagnosis of unicameral bone cysts. Skeletal Radiol. 38(6):597-600, 2009
                                                                                  11. Khurana A et al: Benign bone cyst mimicking skeletal metastasis on (18)F-FDG-PET. Hell J Nucl Med. 12(2):179-80, 2009
                                                                                  12. Mik G et al: Results of a minimally invasive technique for treatment of unicameral bone cysts. Clin Orthop Relat Res. 467(11):2949-54, 2009
                                                                                  13. Polat O et al: Our clinical experience on calcaneal bone cysts: 36 cysts in 33 patients. Arch Orthop Trauma Surg. 129(11):1489-94, 2009
                                                                                  14. Ruggieri P et al: Tumours and tumour-like lesions of the hip in the paediatric age: a review of the Rizzoli experience. Hip Int. 19 Suppl 6:S35-45, 2009
                                                                                  15. Tey IK et al: Active unicameral bone cysts in the upper limb are at greater risk of fracture. J Orthop Surg (Hong Kong). 17(2):157-60, 2009
                                                                                  16. Thawrani D et al: Successful treatment of unicameral bone cyst by single percutaneous injection of alpha-BSM. J Pediatr Orthop. 29(5):511-7, 2009
                                                                                  17. Wootton-Gorges SL: MR imaging of primary bone tumors and tumor-like conditions in children. Magn Reson Imaging Clin N Am. 17(3):469-87, vi, 2009
                                                                                  18. Sung AD et al: Unicameral bone cyst: a retrospective study of three surgical treatments. Clin Orthop Relat Res. 466(10):2519-26, 2008
                                                                                  19. Snyder BD et al: Predicting fracture through benign skeletal lesions with quantitative computed tomography. J Bone Joint Surg Am. 88(1):55-70, 2006
                                                                                  20. Shankman S et al: MR imaging of tumors and tumor-like lesions of the upper extremity. Magn Reson Imaging Clin N Am. 12(2):349-59, 2004
                                                                                  21. Zampa V et al: MR evaluation of bone cysts treated with intracavital steroid injection. Eur Radiol. 13(6):1348-56, 2003
                                                                                  22. Abdel-Wanis ME et al: Simple bone cyst is not a single entity: point of view based on a literature review. Med Hypotheses. 58(1):87-91, 2002
                                                                                  23. Kalil RK et al: Simple bone cyst. In Fletcher CDM et al: World Health Organization Classification of Tumours: Tumours of Soft Tissue and Bone. IARC Press, 2002